The neural basis of memory. Although they define us, our knowledge about how, and where, memories are processed and stored within the brain is still in its infancy. This project aims to investigate the morphological and functional changes that occur in cortical neurons during memory formation. By recording from both mouse and human neurons, this study will bridge the gap in knowledge between the heavily-investigated rodent brain and the human brain and advance our knowledge on how remote memorie ....The neural basis of memory. Although they define us, our knowledge about how, and where, memories are processed and stored within the brain is still in its infancy. This project aims to investigate the morphological and functional changes that occur in cortical neurons during memory formation. By recording from both mouse and human neurons, this study will bridge the gap in knowledge between the heavily-investigated rodent brain and the human brain and advance our knowledge on how remote memories are formed in individual neurons within the frontal cortex of the brain. These findings will highlight potential neural mechanisms that might be awry in cases of memory loss and amnesia.Read moreRead less
Engineering nanoscale tools for cellular interrogation. The aim is to address fundamental hurdles to engineering seamless nanobiointerfaces between electroactive nanoscale tools and living cells. This is expected to allow efficient delivery of many bioactive cargo types into cells, intracellular sampling of cytosol contents, and probing of action potential, all at the cell—material interface. New, powerful, electroactive nanoscale tools that deliver precise spatio-temporal resolution and minimal ....Engineering nanoscale tools for cellular interrogation. The aim is to address fundamental hurdles to engineering seamless nanobiointerfaces between electroactive nanoscale tools and living cells. This is expected to allow efficient delivery of many bioactive cargo types into cells, intracellular sampling of cytosol contents, and probing of action potential, all at the cell—material interface. New, powerful, electroactive nanoscale tools that deliver precise spatio-temporal resolution and minimal invasiveness and perturbation are likely to transform ex-vivo cellular processes. The intended outcomes are crucial for maximising precision in engineering and implementing of ex-vivo cellular processes. Fundamental advances in knowledge may eventually be a platform for developing cell-based therapies.
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Improving workplace productivity via an AI-based physical activity chatbot . This project aims to develop, train and evaluate a physical activity chatbot using artificial intelligence and machine learning to improve workplace productivity in sedentary office workers. Productivity losses, due to high numbers of physically inactive workers, cost the Australian economy $14 billion per year. The cost of effective and scalable workplace physical activity programs acts as a barrier to their implementa ....Improving workplace productivity via an AI-based physical activity chatbot . This project aims to develop, train and evaluate a physical activity chatbot using artificial intelligence and machine learning to improve workplace productivity in sedentary office workers. Productivity losses, due to high numbers of physically inactive workers, cost the Australian economy $14 billion per year. The cost of effective and scalable workplace physical activity programs acts as a barrier to their implementation. As such, innovative programs that can reach large numbers of workers at minimal cost are needed. This project aims to generate new knowledge on the use of artificial intelligence to achieve behavioural improvements and will lead to the development of a new type of behaviour change program with broad applicability.
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Next-generation methods for transport in poroelastic media with interfaces. Deformable porous structures are ubiquitous in the design of materials such as filters, sponges, and prosthetics. They often show complex mechano-chemical processes that occur across several spatio-temporal scales. To mathematically describe them requires coupled sets of nonlinear, multiphysical, and multiscale equations. This makes the design of accurate, efficient numerical methods challenging. The Fellowship aims to a ....Next-generation methods for transport in poroelastic media with interfaces. Deformable porous structures are ubiquitous in the design of materials such as filters, sponges, and prosthetics. They often show complex mechano-chemical processes that occur across several spatio-temporal scales. To mathematically describe them requires coupled sets of nonlinear, multiphysical, and multiscale equations. This makes the design of accurate, efficient numerical methods challenging. The Fellowship aims to address the mathematical characteristics encountered in poromechanics equations and their discretisation methods, and to devise novel mathematical and computational techniques for extending the analysis to cases where large deformations and the presence of interfaces and coupling with other neighbouring elements are relevant.Read moreRead less