The role of emotion and social cognition in communication disorders. Social neuroscience is a rapidly emerging field that has identified the frontal systems of the brain as critical to social cognition, i.e. the ability to process specifically social information. Communication disorders also arising from frontal lobe damage are directly relevant to this field but have been ignored to date. This project represents cutting edge research putting Australia at the forefront in this endeavour. Not ....The role of emotion and social cognition in communication disorders. Social neuroscience is a rapidly emerging field that has identified the frontal systems of the brain as critical to social cognition, i.e. the ability to process specifically social information. Communication disorders also arising from frontal lobe damage are directly relevant to this field but have been ignored to date. This project represents cutting edge research putting Australia at the forefront in this endeavour. Not only is this research theoretically important but it is directly relevant to clinical management and remediation of the thousands of people in Australia who suffer brain injury annually and who suffer psychosocial disorders as a result. Read moreRead less
Neural and cognitive studies of reward sensitivity and its influence on addiction-related behaviour. The proposed research aims to contribute to current scientific thinking on the influence of reward sensitivity on cognitive performance. Cognitive neuroscience research on this relationship is of major scientific interest because heightened reward sensitivity is a significant predictor of risk for a number of Australia's major social and economic problems. The findings of this project will contri ....Neural and cognitive studies of reward sensitivity and its influence on addiction-related behaviour. The proposed research aims to contribute to current scientific thinking on the influence of reward sensitivity on cognitive performance. Cognitive neuroscience research on this relationship is of major scientific interest because heightened reward sensitivity is a significant predictor of risk for a number of Australia's major social and economic problems. The findings of this project will contribute to the debate about how to manage such problems.Read moreRead less
Development of integrated biological markers of brain function. With the rapid growth of both brain imaging and genetics, we can now examine the biological basis of complex brain functions, such as memory. Our goal is to combine these techniques to develop evidence-based biological markers of normal function. These markers can then be used to screen for early signs of abnormal function (eg. in Alzheimer's disease) and to assess treatment effects. Two unique features ensure the project's feasibil ....Development of integrated biological markers of brain function. With the rapid growth of both brain imaging and genetics, we can now examine the biological basis of complex brain functions, such as memory. Our goal is to combine these techniques to develop evidence-based biological markers of normal function. These markers can then be used to screen for early signs of abnormal function (eg. in Alzheimer's disease) and to assess treatment effects. Two unique features ensure the project's feasibility: a) access to the first standardized, normative brain database (from the Brain Resource Company Ltd) and b) a scientific collaboration supporting the integration of brain imaging and genetics.Read moreRead less
Glucose facilitation of cognitive function: Effects of effort, age and glucose control. Age-related decline in mental capacity contributes to the economic (estimated at over 2 trillion AUD by 2050), social and human costs of an increasingly older Australian population. The studies in this program aim to understand the role of poor control of blood glucose in age-related cognitive deficits. The role of individual differences in biological (hormonal responses) and psychological (stress and appetit ....Glucose facilitation of cognitive function: Effects of effort, age and glucose control. Age-related decline in mental capacity contributes to the economic (estimated at over 2 trillion AUD by 2050), social and human costs of an increasingly older Australian population. The studies in this program aim to understand the role of poor control of blood glucose in age-related cognitive deficits. The role of individual differences in biological (hormonal responses) and psychological (stress and appetite) factors will also be assessed. A better understanding of the nature of age-related cognitive decline as it relates to biological processes such as blood glucose control will help to develop tangible strategies to combat age-related cognitive decline and dementia (which has been described as Type 3 diabetes).Read moreRead less
Dissociating facial processing pathways for static and dynamic information. Abnormalities in social cognition are increasingly recognised as representing core features of a number of psychiatric disorders including autism, Aspberger's syndrome, and schizophrenia, however, the brain mechanisms underlying such abilities in the healthy brain are still not well understood. The current proposal aims to use Transcranial Magnetic Stimulation to explore the role of specific brain regions in subserving a ....Dissociating facial processing pathways for static and dynamic information. Abnormalities in social cognition are increasingly recognised as representing core features of a number of psychiatric disorders including autism, Aspberger's syndrome, and schizophrenia, however, the brain mechanisms underlying such abilities in the healthy brain are still not well understood. The current proposal aims to use Transcranial Magnetic Stimulation to explore the role of specific brain regions in subserving an important aspect of social functioning; the processing of facial information. As such, the study will significantly enhance our understanding of the neural mechanisms of such processes in healthy brains, thus also informing our understanding of the pathological mechanisms associated with these psychiatric conditions.Read moreRead less
Social psychological, personality, and neural processes underlying anger, aggression, and health. The Australian Institute of Criminology estimates the cost of assault, sexual assault, and homicide in Australia at over $2.5 billion per annum. Despite these enormous costs, very little is known about the cognitive and neural mechanisms guiding these phenomena. This research will also provide cues regarding risk for domestic violence. Understanding domestic violence is especially significant bec ....Social psychological, personality, and neural processes underlying anger, aggression, and health. The Australian Institute of Criminology estimates the cost of assault, sexual assault, and homicide in Australia at over $2.5 billion per annum. Despite these enormous costs, very little is known about the cognitive and neural mechanisms guiding these phenomena. This research will also provide cues regarding risk for domestic violence. Understanding domestic violence is especially significant because it is the leading cause of homicide among women in Australia. The insights gained from this research may lead to substantial social (e.g., stronger social fabric, reduced crime) and economic benefit (e.g., reduced spending on healthcare and crime).Read moreRead less
Cognitive, behavioural and educational outcomes of fetal antiepileptic drug exposure. The study falls within the National Research Priority of Promoting and Maintaining Good Health, in particular the Priority Goal - A Healthy Start to Life. The research will yield information crucial to our understanding of the effects of fetal AED exposure on cognitive and behavioural development in the significant number of affected Australian children born each year. It will enhance the nation's ability to de ....Cognitive, behavioural and educational outcomes of fetal antiepileptic drug exposure. The study falls within the National Research Priority of Promoting and Maintaining Good Health, in particular the Priority Goal - A Healthy Start to Life. The research will yield information crucial to our understanding of the effects of fetal AED exposure on cognitive and behavioural development in the significant number of affected Australian children born each year. It will enhance the nation's ability to develop strategies for prevention, surveillance and remediation of adverse outcomes in early childhood, thus supporting the Government's National Agenda for Early Childhood initiative. As a consequence educational assistance can be targeted for those children likely to experience difficulties. Read moreRead less
Cognitive and neural mechanisms underlying lateral biases in human vision. Under conditions of unconstrained viewing, humans show a consistent and reliable asymmetry in their perception of visual stimuli. This bias, which favours the left side, arises at a post-retinal level and is hypothesised to reflect hemispheric asymmetry in the control of visuospatial attention. This program of research investigates the mechanisms underlying lateral biases in visual perception, using the latest cognitive n ....Cognitive and neural mechanisms underlying lateral biases in human vision. Under conditions of unconstrained viewing, humans show a consistent and reliable asymmetry in their perception of visual stimuli. This bias, which favours the left side, arises at a post-retinal level and is hypothesised to reflect hemispheric asymmetry in the control of visuospatial attention. This program of research investigates the mechanisms underlying lateral biases in visual perception, using the latest cognitive neuroscience techniques. The findings will provide important new information about the neural and cognitive bases for normal and disordered visuospatial perception. The goal is to develop a novel test of perceptual asymmetries for use in normal participants and neurological patients.Read moreRead less
Validation of a New Conceptual Model of ADHD based on Underlying Central Nervous System Dysfunction. ADHD is a debilitating problem that affects 5% of children and approximately half as many adults. ADHD causes substantial problems at school and if untreated, predisposes the individual to increased drug and alcohol use, marital breakdown, criminal prosecution and psychiatric problems in later life. One problem is that we do not fully understand what are the causes of the disorder. This project w ....Validation of a New Conceptual Model of ADHD based on Underlying Central Nervous System Dysfunction. ADHD is a debilitating problem that affects 5% of children and approximately half as many adults. ADHD causes substantial problems at school and if untreated, predisposes the individual to increased drug and alcohol use, marital breakdown, criminal prosecution and psychiatric problems in later life. One problem is that we do not fully understand what are the causes of the disorder. This project will test the validity of several models of brain dysfunction in ADHD which have been influential in the literature, but poorly tested. Through better understanding of the basic underlying problems, more effective intervention can be developed.Read moreRead less
Attentional biases that underlie free-viewing perceptual asymmetries: Endogenous and exogenous effects in a behavioural/imaging study. As we move our eyes and attention around us, we are capable of interacting with any part of our immediate environment. It is intriguing, therefore, to discover that the upper and leftward features of an object are more salient than those on the bottom or right. By investigating the nature of these attentional biases in normal individuals, this research will impro ....Attentional biases that underlie free-viewing perceptual asymmetries: Endogenous and exogenous effects in a behavioural/imaging study. As we move our eyes and attention around us, we are capable of interacting with any part of our immediate environment. It is intriguing, therefore, to discover that the upper and leftward features of an object are more salient than those on the bottom or right. By investigating the nature of these attentional biases in normal individuals, this research will improve our understanding of the thought processes and brain structures that control spatial attention. This research has important implications for the development of remedial programs for patients with attentional disorders. The test we use to measure attentional asymmetries has the potential to become an important tool for the early detection of clinical abnormalities in attention.
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