Gestational diabetes (GDM) is a common complication of pregnancy with significant consequences. Early identification and lifestyle intervention can prevent GDM, but the best early screening test is unknown. Our primary aim is to validate our first trimester screening test for GDM in a large multi-ethnic cohort to accurately predict high-risk women and intervene early, preventing GDM onset and improving pregnancy outcomes, including long-term risk of obesity in the offspring.
High Protein, Low Glycemic Load Weight Loss Diets In Type 2 Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$906,928.00
Summary
High protein, low glycemic load weight loss diets have the potential to be of value in long term weight control but there is little long term data available. There is also some uncertainty about the long term safety of high protein diets and this needs clarification in long term trials. As compliance to the diet is the major issue in long term trials we will explore new ways of getting people to stay in long term studies and maintain a calorie reduced diet.
PREVention Of Diabetes Through Lifestyle Intervention And Population Studies In Europe And Around The World
Funder
National Health and Medical Research Council
Funding Amount
$345,281.00
Summary
The PREVIEW Study will identify the most efficient lifestyle pattern for the prevention of type-2 diabetes in a population of pre-diabetic overweight or obese individuals. The project comprises two distinct lines of evidence, an intervention study and population studies. The focus will be on diet (specifically protein and glycemic index) and intensity of physical activity, as well as their interaction with the lifestyle factors, habitual stress, sleeping pattern, behavioural, environmental, cult ....The PREVIEW Study will identify the most efficient lifestyle pattern for the prevention of type-2 diabetes in a population of pre-diabetic overweight or obese individuals. The project comprises two distinct lines of evidence, an intervention study and population studies. The focus will be on diet (specifically protein and glycemic index) and intensity of physical activity, as well as their interaction with the lifestyle factors, habitual stress, sleeping pattern, behavioural, environmental, cultural, and socioeconomic variables.Read moreRead less
Obesity and insulin resistance are an escalating health problem in Australian adolescents. Unmanaged, they are likely to progress to type 2 diabetes and early atherosclerosis and which may pose a major burden on health care resources. However, treatment strategies are currently limited because of the lack of evidence. This PhD research aims to identify, summarise and test an effective and evidence-based approach of dietary management for overweight/obese adolescents and older children with clini ....Obesity and insulin resistance are an escalating health problem in Australian adolescents. Unmanaged, they are likely to progress to type 2 diabetes and early atherosclerosis and which may pose a major burden on health care resources. However, treatment strategies are currently limited because of the lack of evidence. This PhD research aims to identify, summarise and test an effective and evidence-based approach of dietary management for overweight/obese adolescents and older children with clinical insulin resistance or prediabetes.Read moreRead less
Outcomes In Early Diagnosis And Intervention For Gestational Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$162,876.00
Summary
Gestational diabetes mellitus (GDM) is a common complication of pregnancy with significant maternal and fetal consequences. The benefits of screening and treatment for GDM after 24 weeks’ gestation are well known, however there is little evidence for early screening and intervention for women with high risk for GDM. The primary aim of this study is to determine whether early diagnosis and intervention improves pregnancy outcomes in GDM, specifically fetal overgrowth.
Fenofibrate And Microvascular Events In Type 1 Diabetes (FAME 1) Trial
Funder
National Health and Medical Research Council
Funding Amount
$2,883,529.00
Summary
Diabetes is one of the commonest cause of blindness in adults. Vision loss, which is irreversible, is a most feared complication of diabetes. A blood fat lowering drug called fenofibrate, available in Australia, has been shown to reduce eye damage in people with Type 2 diabetes by 35-40%, and to prevent eye damage in Type 1 diabetic animal models. This study will evaluate the potential benefits of fenofibrate in 450 adults with Type 1 diabetes who have early diabetic eye damage.
The overall aim is to improve treatments and outcomes for people with osteoporosis. This will be achieved by better predicting those who are likely to fracture and subsequently those who do well post fracture from those who do poorly. Following an osteoporotic fracture there is an increased risk of re- fracture and of premature death. This research will define those risk factors for fracture, re-fracture and early death in a large group of men and women followed for over 20 years.
Defining the molecular and cellular mechanisms of beta cell dysfunction. This project will investigate the influence of environment in the functional adaptation and maladaptation of pancreatic beta cells in diabetes. The research will define the molecular and cellular mechanisms linking environmental triggers such as obesity, high fatty acid levels and hyperglycaemia to beta cell dedifferentiation and dysfunction.