Molecular Determinants Of Therapeutic Response In Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$87,646.00
Summary
Colorectal cancer (CRC) is the second most common cause of cancer death. We will examine whether treatments of advanced CRC can be optimized by (1) selection based on the patient's expression of biomarkers (ie. cancer proteins) and-or (2) appropriate combinations of chemotherapy and-or immunotherapy. Using samples from patients we aim to determine predictors of response to a single therapy (bevacizumab) or a novel combination of therapies (erlotonib and cetuximab) to enhance future treatments.
National Resource For Public Good, Web-based Investigator-initiated Trials
Funder
National Health and Medical Research Council
Funding Amount
$1,290,000.00
Summary
The facility will provide resources in clinical trials expertise and web-based trials systems to enable investigator-initiated clinical trials of public good. This should ensure that the highest quality of clinical trials research can be undertaken by clinical trials researchers in new and priority health research areas, at any institution throughout Australia. Areas supported through this national resource will include controlled trials of current clinical practice, surgery, new health technolo ....The facility will provide resources in clinical trials expertise and web-based trials systems to enable investigator-initiated clinical trials of public good. This should ensure that the highest quality of clinical trials research can be undertaken by clinical trials researchers in new and priority health research areas, at any institution throughout Australia. Areas supported through this national resource will include controlled trials of current clinical practice, surgery, new health technologies, palliative and supportive care and complementary medicine.Read moreRead less
Low back pain affects one in four people in Australia and is responsible for over $8 billion spent on treatments and work loss every year. Surgery is a popular treatment approach for this multifactorial condition but we still lack high quality science to support the role of surgery for low back pain. We also lack research capacity in this field. In my fellowship, I propose to conduct high quality studies to generate and implement scientific knowledge in this field.
Fetal Lactate Measurement To Reduce Caesarean Sections During Labour: A Randomised Trial
Funder
National Health and Medical Research Council
Funding Amount
$386,600.00
Summary
Caesarean section rates in Australia are well above the World Health Organization’s recommended level. Many babies appear unhealthy in labour, so they are born by caesarean. They are usually healthy at birth, meaning that the operation could have been avoided. In this study, half the babies who seem distressed will have a blood test for lactate and the other half will not. We will then determine whether having a lactate test makes a difference in the number women having caesarean births.