Modelling applications of nanomaterials in biology and medicine. This proposal will address fundamental issues related to nanomaterials and their applications in biology and medicine. Accurate mathematical models will be formulated, leading to new practical techniques in nanobiotechnology, safe and effective methods to diagnose and cure diseases including cancer via targeted drug and gene delivery, and detection methods for biological hazards, such as those arising from biological terrorism. The ....Modelling applications of nanomaterials in biology and medicine. This proposal will address fundamental issues related to nanomaterials and their applications in biology and medicine. Accurate mathematical models will be formulated, leading to new practical techniques in nanobiotechnology, safe and effective methods to diagnose and cure diseases including cancer via targeted drug and gene delivery, and detection methods for biological hazards, such as those arising from biological terrorism. The research facility proposed involves significant training of applied mathematicians at honours, PhD and postdoctoral levels and multidisciplinary collaboration, ensuring that Australia maintains and develops an expertise in nanobiotechnology well into the future.Read moreRead less
Special Research Initiatives - Grant ID: SR0354797
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
The Australian Tissue Engineering Network. Driven by four key nodes across the country, the Initiative aims to bring together geographically and financially separated groups into a critical mass of cell and tissue engineering research. This new and rapidly-growing field uses a bio-synthetic approach to replace, repair or regenerate damaged tissues and organs. The Initiative will build the framework which will enable the Network to: identify appropriate expertise, manage duplication, enhance co ....The Australian Tissue Engineering Network. Driven by four key nodes across the country, the Initiative aims to bring together geographically and financially separated groups into a critical mass of cell and tissue engineering research. This new and rapidly-growing field uses a bio-synthetic approach to replace, repair or regenerate damaged tissues and organs. The Initiative will build the framework which will enable the Network to: identify appropriate expertise, manage duplication, enhance communication, bring together innovative skill sets, create linkages, generate focussed research programs and foster novel commercial opportunities. Ultimately the Initiative and Network will deliver an improved quality of life, reduced healthcare costs, and increased productivity to Australia.Read moreRead less
Progressive liquefaction within marine sediments: comparison between geo-centrifuge modelling, full-scale wave tank tests and numerical modelling. The evaluation of wave-induced liquefaction within the marine sediment is particularly important for coastal and geotechnical engineers involved in the design of foundation around coastal structures. The proposed study will integrate the existing knowledge from the aspects of coastal and geotechnical engineering with that of overseas experts to provid ....Progressive liquefaction within marine sediments: comparison between geo-centrifuge modelling, full-scale wave tank tests and numerical modelling. The evaluation of wave-induced liquefaction within the marine sediment is particularly important for coastal and geotechnical engineers involved in the design of foundation around coastal structures. The proposed study will integrate the existing knowledge from the aspects of coastal and geotechnical engineering with that of overseas experts to provide coastal engineers with an effective tool for the design of foundations around marine structures. It will also assist in reducing the risk of potential environmental damage caused by failure of marine structures.Read moreRead less
Mathematical and mechanical modeling of nano particulate flow. Nano particulates are the basis for many new technologies, including coatings in the electronics industry, composite materials and medical and pharmaceutical applications. Worldwide industrial competition is increasingly determined by our capacity to handle such highly cohesive materials, and to exploit their novel physical, chemical and mechanical characteristics. Devising handling mechanisms and understanding nano particulate flows ....Mathematical and mechanical modeling of nano particulate flow. Nano particulates are the basis for many new technologies, including coatings in the electronics industry, composite materials and medical and pharmaceutical applications. Worldwide industrial competition is increasingly determined by our capacity to handle such highly cohesive materials, and to exploit their novel physical, chemical and mechanical characteristics. Devising handling mechanisms and understanding nano particulate flows depends on formulating accurate mathematical models which reflect the correct underlying physics. This APF proposal will utilise advanced continuum mechanics to develop the correct underlying conceptual ideas to resolve fundamental nanomechanical particulate flows, which will lead to the next generation of engineering tools.
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Geotechnical characterisation of compacted ground based on passive ambient noise techniques. The proposed research will provide our local construction and mining industries with a much needed fast and low cost technology for geotechnical investigation of very large sites which is currently not available. The project will help steer Australia to the forefront of ambient noise research for geotechnical site investigation, in the characterisation of unsaturated compacted soil and in the determinati ....Geotechnical characterisation of compacted ground based on passive ambient noise techniques. The proposed research will provide our local construction and mining industries with a much needed fast and low cost technology for geotechnical investigation of very large sites which is currently not available. The project will help steer Australia to the forefront of ambient noise research for geotechnical site investigation, in the characterisation of unsaturated compacted soil and in the determination of dynamic site characteristics which are required for seismic risk assessment. Two postgraduate students will benefit from this research by receiving research training at the highest level and it will also pave the way for exporting the technology developed overseas, particularly to our near neighbours in Asia and the Pacific. Read moreRead less
Response of residential structures to blast vibration. This proposed project combines the expertise and disciplines of residential construction, structural dynamics and blasting technology. The ultimate aim of the project is to develop a rational methodology for assessing the damage potential of ground vibration resulting from blasting on typical Australian residential structures. The project involves field blast vibration measurements, static and dynamic laboratory tests on structural sub-assem ....Response of residential structures to blast vibration. This proposed project combines the expertise and disciplines of residential construction, structural dynamics and blasting technology. The ultimate aim of the project is to develop a rational methodology for assessing the damage potential of ground vibration resulting from blasting on typical Australian residential structures. The project involves field blast vibration measurements, static and dynamic laboratory tests on structural sub-assemblages in a controlled environment, and comprehensive analytical modelling of both loading and response. The outcomes from this research will have direct application to the mining, insurance, construction and defence industries.Read moreRead less
Assessment and Prediction of Particle Breakage under Cyclic Loading. Every year, transport industries spend millions of dollars to maintain existing tracks suffering excessive settlement due to heavy traffic. In railways, differential settlement and track fouling are mostly due to ballast breakage. Frequent maintenance requires large amounts of quarried ballast causing environmental degradation. Simulation of particle breakage subject to cyclic loading is pioneering fundamental research that wi ....Assessment and Prediction of Particle Breakage under Cyclic Loading. Every year, transport industries spend millions of dollars to maintain existing tracks suffering excessive settlement due to heavy traffic. In railways, differential settlement and track fouling are mostly due to ballast breakage. Frequent maintenance requires large amounts of quarried ballast causing environmental degradation. Simulation of particle breakage subject to cyclic loading is pioneering fundamental research that will have significant impact on the design and maintenance of future rail and road networks. A full understanding of the breakage mechanisms of aggregates will lead to innovative techniques in design and construction, including faster trains carrying heavier loads with reduced maintenance costs.Read moreRead less
Friction and contact in soil-structure-interaction. Frictional contact, which occurs at soil-structure interfaces, has a major influence on the behaviour of many civil engineering structures such as building foundations and soil anchor systems. To better understand this phenomenon, new theoretical models and solution algorithms are needed to simulate soil-structure interaction. This project aims to develop these models and algorithms. Its outcomes will lead to improved prediction methods and bet ....Friction and contact in soil-structure-interaction. Frictional contact, which occurs at soil-structure interfaces, has a major influence on the behaviour of many civil engineering structures such as building foundations and soil anchor systems. To better understand this phenomenon, new theoretical models and solution algorithms are needed to simulate soil-structure interaction. This project aims to develop these models and algorithms. Its outcomes will lead to improved prediction methods and better geotechnical design strategies.Read moreRead less
FRICTION AND CONTACT IN SOIL-STRUCTURE INTERACTION AT LARGE DEFORMATION. The proposed research addresses the fundamental mechanics of contact for a wide range of civil engineering structures such as piles, retaining walls, and soil anchors. Piles and anchors are essential parts of off-shore platforms which, in turn, are key elements of the Australian oil and gas industry. The numerical tool the project aims to develop is capable of analysing the entire process of installation and loading of a pi ....FRICTION AND CONTACT IN SOIL-STRUCTURE INTERACTION AT LARGE DEFORMATION. The proposed research addresses the fundamental mechanics of contact for a wide range of civil engineering structures such as piles, retaining walls, and soil anchors. Piles and anchors are essential parts of off-shore platforms which, in turn, are key elements of the Australian oil and gas industry. The numerical tool the project aims to develop is capable of analysing the entire process of installation and loading of a pile foundation. Such a tool does not currently exist and will result in safer and cheaper geotechnical design. The methods developed in this project can also be extended to study human joints and joint replacements.Read moreRead less
Contaminant Transport in Marine Sediment. Sediments in bays and estuaries are often contaminated. The inorganic contaminants in sediments can be released back into the water body through mass transfer processes. The mass transfer rate is largely controlled by the wave-driven seepage flux across the seabed. Quantification of this flux is thus a key factor in modelling water quality of coastal water bodies. This project aims to: (1) develop models forwave-induced seepage flux within sediments and ....Contaminant Transport in Marine Sediment. Sediments in bays and estuaries are often contaminated. The inorganic contaminants in sediments can be released back into the water body through mass transfer processes. The mass transfer rate is largely controlled by the wave-driven seepage flux across the seabed. Quantification of this flux is thus a key factor in modelling water quality of coastal water bodies. This project aims to: (1) develop models forwave-induced seepage flux within sediments and contaminant transport; and (2) establish the link between seepage flux and contaminant transport. Outcomes of the proposed research will enhance the understanding of the mechanism of contaminant transport in marine sediment.Read moreRead less