A Dimensional-spectrum Model Of Mental Disorders: Developing New Assessments To Improve The Diagnostic Validity Of Multiple Mental Disorders
Funder
National Health and Medical Research Council
Funding Amount
$311,860.00
Summary
Advances in the scientific literature have highlighted that significant improvements to validity and clinical utility can be made through the use of a dimensional-spectrum model of psychopathology. To encourage the future use of the dimensional-spectrum model, the current research project aims to develop and test an innovative and novel assessment tool for diagnosing mental disorders in community and clinical populations using a dimensional-spectrum model as the guiding theoretical framework.
A Multi-site Randomised Controlled Trial Comparing The Severity Of Constipation Symptoms Experienced By Palliative Care Patients Receiving Usual Care Compared To Those Diagnosed And Managed According To The Underlying Pathophysiology.
Funder
National Health and Medical Research Council
Funding Amount
$498,795.00
Summary
This research aims to consider whether the problems of constipation in palliative care are less severe when the physical changes that underlie the problem are explored.
Better Data To Inform Interventions To Reduce The Risk Of Stillbirth In Australia
Funder
National Health and Medical Research Council
Funding Amount
$75,830.00
Summary
Stillbirth is a devastating experience for parents and families. Paucity of high quality data on causes and contributing factors is a major barrier to the development of research priorities and interventions to prevent stillbirths and improve the quality of care. This research will be a connected body of work that aims to better describe the epidemiology of stillbirth in Australia, contribute to the classification of stillbirths and determine the needs of parents in relation to autopsy consent.
Defining The Role Of The Major Subsets Of Renal Mononuclear Phogocytes
Funder
National Health and Medical Research Council
Funding Amount
$614,227.00
Summary
Chronic Kidney Disease (CKD) is a major cause of death and morbidity in Australia, and currently therapeutic options are limited. Renal mononuclear phagocytes (rMP) are important immune cells which play a central role in health and disease of the kidney. However, rMP are a heterogenous group of cells with a poorly defined role in the development and progression of CKD. We will define the role of major subsets of rMP in CKD, and explore their potential for treating CKD.
Translational Genomics And Combinatorial Drug Discovery To Improve Outcomes For Patients With Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$640,210.00
Summary
Bowel cancer is a major public health burden in Australia. Over the next 5 years, A/Prof Sieber’s research will focus on understanding the molecular pathology of bowel cancer and how this determines the course of disease and response to therapy. Integrated genomic, functional and drug discovery studies will provide significant new insights into fundamental tumour biology and open up new avenues for diagnosis and treatment.