RENAL VASCULAR HYPERTROPHY AND REMODELLING IN SHR: SYMPATHETIC NERVOUS SYSTEM AND IMPLICATIONS FOR HYPERTENSION
Funder
National Health and Medical Research Council
Funding Amount
$191,561.00
Summary
High blood pressure (hypertension) remains a major health problem for Australians. One in six Australians suffer from hypertension, with consequent increased risk of stroke and heart attack. Anti-hypertensive treatments are available, but must usually be taken for the rest of the patient's life and the cost to the taxpayer of anti-hypertensive drugs is greater than for any other health problem. Prevention of high blood pressure depends on identifying the initial cause - but we still do not know ....High blood pressure (hypertension) remains a major health problem for Australians. One in six Australians suffer from hypertension, with consequent increased risk of stroke and heart attack. Anti-hypertensive treatments are available, but must usually be taken for the rest of the patient's life and the cost to the taxpayer of anti-hypertensive drugs is greater than for any other health problem. Prevention of high blood pressure depends on identifying the initial cause - but we still do not know the cause in over 90% of hypertensive people. This project will study whether overactivity of the nerves to the blood vessels of the kidney might be the cause. There is evidence for this in humans, and in a strain of rats which develops high blood pressure (the spontaneously hypertensive rat). Our experiments will study these rats to see whether nerves affect the structure and function of the blood vessels of the kidney in ways that lead to increased blood pressure.Read moreRead less
A lack of oxygen in the kidney (hypoxia) is a primary cause of kidney disease, but the mechanisms are not clear. To determine the processes involved, we will take a new approach; combining a mathematical model with studies of kidney oxygen regulation in both normal and diseased kidneys. We will determine the causes of hypoxia in kidney disease, and find out if preventing hypoxia has the potential to be a treatment for kidney disease.
Changing Decision-making Behaviour In General Practice By Providing Access To Online Evidence.
Funder
National Health and Medical Research Council
Funding Amount
$206,375.00
Summary
The case for a shift to evidence-based practice, and the substantial economic and health outcome benefits of that shift, have been repeatedly made. Despite the vision, significant barriers to evidence-based practice remain, and the demonstration of a positive role for on-line systems would result in a significant change in strategies for clinician behaviour change. This study will make a specific and significant contribution to our understanding of the efficacy and effectiveness of online eviden ....The case for a shift to evidence-based practice, and the substantial economic and health outcome benefits of that shift, have been repeatedly made. Despite the vision, significant barriers to evidence-based practice remain, and the demonstration of a positive role for on-line systems would result in a significant change in strategies for clinician behaviour change. This study will make a specific and significant contribution to our understanding of the efficacy and effectiveness of online evidence retrieval systems as a component in any evidence-based strategy, through a rigorous and controlled approach to the study of clinical behaviour change. It will also provide a powerful test of the value of search filters as a specific technology in support of evidence retrieval. The focus on prescribing patterns in NHMRC priority areas as an outcome measure will also provide a significant data set reflecting current practice in primary care.Read moreRead less
Social Aspects And Cultural Meanings Of Gynaecological Cancer Diagnosis, Treatment And Adjustment Of Victorian Women
Funder
National Health and Medical Research Council
Funding Amount
$158,500.00
Summary
Most research worldwide concerning gynaecological cancers has related to cervical cancer screening because of the effectiveness of Pap tests, while limited research has been conducted on social aspects of cancer. However, cancer of the uterus and ovary are among the top ten cancers in Australian women, and the diagnosis of a gynaecological cancer has a profound effect on women. This study is concerned with women's understandings of cancer disease, its treatment and outcomes, and with social fact ....Most research worldwide concerning gynaecological cancers has related to cervical cancer screening because of the effectiveness of Pap tests, while limited research has been conducted on social aspects of cancer. However, cancer of the uterus and ovary are among the top ten cancers in Australian women, and the diagnosis of a gynaecological cancer has a profound effect on women. This study is concerned with women's understandings of cancer disease, its treatment and outcomes, and with social factors that may influence their treatment decisions and care. The study will be conducted in metropolitan and rural Victoria. Women from a variety of ethnic, language and social backgrounds, who have been diagnosed with gynaecological cancer in the preceding three years, will be interviewed to gain insight into their understandings and experiences of the processes of disease, diagnosis and treatment procedures, the implications of for daily life, and the relationship of these events to their perceptions of their bodies, gender and sexuality. We will also interview oncologists and cancer support group facilitators, and participate in cancer support groups, to examine the role of such groups and to explore the experiences of health professionals providing care to women with these cancers. Research findings will be used to develop health educational information about gynaecological cancers, and to provide information to hospitals and clinicians to improve quality of clinical care and social support.Read moreRead less