Relationship Between Anterior Cingulate Morphology, Neuronal Integrity And Function In Schizophrenia And OCD
Funder
National Health and Medical Research Council
Funding Amount
$312,813.00
Summary
Schizophrenia and obsessive-compulsive disorder (OCD) are extremely disabling psychiatric disorders. Both tend to appear in early adulthood and have a number of important similarities. These include problems with planning and organising thoughts, abnormal brain chemistry, and changed function in the same brain region, the anterior cingulate. The anterior cingulate has been known for some time to be involved in emotion, motivation and attention. However, it is now recognised as the interface betw ....Schizophrenia and obsessive-compulsive disorder (OCD) are extremely disabling psychiatric disorders. Both tend to appear in early adulthood and have a number of important similarities. These include problems with planning and organising thoughts, abnormal brain chemistry, and changed function in the same brain region, the anterior cingulate. The anterior cingulate has been known for some time to be involved in emotion, motivation and attention. However, it is now recognised as the interface between the emotional, feeling part of the brain and the controlling, thinking part. Many, if not all, of the functions performed by the anterior cingulate are disturbed in both schizophrenia and OCD, meaning that studying this region may provide important clues to the nature of the two illnesses. One important characteristic of the anterior cingulate which has not been considered in previous research is its division into three distinct subregions, each with their own specific function. In particular, there is a cognitive region, which deals with response selection and information processing, and an emotional region, which assesses motivational content and controls emotional learning. Because of the nature of the two disorders we intend to study, we believe that schizophrenia will be associated with more abnormalities of the cognitive region, while OCD will be associated with changes in the emotional region. Another important feature of our research design is that we intend to collect data from the same subjects using four separate brain imaging techniques, which provide information about different levels of brain structure and function. This will allow us to interpret our findings from measures of brain chemistry in the context of our findings of brain function. Hopefully this will help us to clarify the pathophysiology of schizophrenia and OCD, and provide potential ways to assess the effect of different treatment strategies in these illnesses.Read moreRead less
The Role Of The Posterior Cingulate Cortex In Verbal Associative Learning
Funder
National Health and Medical Research Council
Funding Amount
$146,500.00
Summary
Functional magnetic resonance imaging (fMRI) is a technique which utilises differences between oxygenated and deoxygenated blood to identify regions which are active when the brain is performing a task. This enables us to determine the regions of the brain which are involved in performing different functions. The brain regions supporting memory and learning functions include the hippocampus, the posterior cingulate cortex (PCC), and the frontal lobes. Research has already established the importa ....Functional magnetic resonance imaging (fMRI) is a technique which utilises differences between oxygenated and deoxygenated blood to identify regions which are active when the brain is performing a task. This enables us to determine the regions of the brain which are involved in performing different functions. The brain regions supporting memory and learning functions include the hippocampus, the posterior cingulate cortex (PCC), and the frontal lobes. Research has already established the importance of the hippocampus in memory and learning. However, the exact role of the PCC and the interaction between the PCC and other memory regions remains unclear. This study will use fMRI to investigate the role of the PCC in memory and learning. Specifically, we will compare the activity associated with performance of a difficult memory task and an easier memory task in healthy subjects. The study will then be repeated in patients sustaining damage to the hippocampus. This part of the study will allow us to see how the PCC adapts to disease in the memory system. The results of this study will further clarify the role of the PCC in memory and learning. In addition, this work may be of great importance in the treatment and rehabilitation of patients with memory disorders.Read moreRead less