Do Exposures Before Conception Influence The Risk Of Asthma In Offspring?
Funder
National Health and Medical Research Council
Funding Amount
$688,586.00
Summary
Asthma and poor lung function are major causes of public health issues. Emerging evidence suggests adverse exposures even before the conception of a child may cause these conditions. The proposed project is part of an international study across generations to identify these factors. This study will provide novel evidence to guide interventions and identify studies to advance this area further. These original findings will be of great importance both nationally and internationally.
DYRK1A As A Novel Target For Glioblastoma Therapies
Funder
National Health and Medical Research Council
Funding Amount
$620,294.00
Summary
Glioblastoma is a form of brain cancer that is currently incurable. We have discovered that switching-off an enzyme called DYRK1A (using ‘DYRK1A inhibitors’) kills glioblastoma cells. This therapeutic advantage is even greater when combined with drugs approved for other cancers. This project will develop new DYRK1A inhibitors and examine a novel combination treatment for glioblastoma patients. This could initiate a novel therapy that could significantly extend patients’ lives.
Functional links between estuaries and their catchments: How does land use change affect estuarine ecological and bio-geochemical function? Estuaries are iconic recreational areas of high ecological and socio-economic value. Estuarine health is strongly linked to the catchments that feed them, yet we have no detailed understanding of these links. This project will use a number of state of the art approaches to better understand how land use affects estuarine health.
Antigen Selection In The MHC-restricted Cellular Immune Response
Funder
National Health and Medical Research Council
Funding Amount
$175,570.00
Summary
The body's white cells eliminate microorganisms through the actions of immune lymphocytes and other cells which conspire to kill and neutralise these unwanted guests. When microorganisms hide inside the cells of the body they are still detected by a set of T lymphocytes which have specific receptors for scrutinising the surface of cells for any changes which might signal an intracellular infection. The immune system is ever vigilant in its search for signs of infection which are generally appare ....The body's white cells eliminate microorganisms through the actions of immune lymphocytes and other cells which conspire to kill and neutralise these unwanted guests. When microorganisms hide inside the cells of the body they are still detected by a set of T lymphocytes which have specific receptors for scrutinising the surface of cells for any changes which might signal an intracellular infection. The immune system is ever vigilant in its search for signs of infection which are generally apparent when molecules called antigens are released by microorganisms and captured by the body's cells. This activates lymphocytes resulting in an immune response capable of eliminating the microorganisms. Scrutiny of the body's cells by lymphocytes occurs continuously even when there is no infection present in the body. Following infection of a cell, microbial antigens reveal the infection by their appearance on the cell surface where they are detected by the immune system's lymphocytes. This occurs through a mechanism called antigen presentation. During antigen presentation the proteins inside the cell, including those of any invading microorganism, are first degraded into shorter molecules called peptides. This event is called antigen processing. A fraction of the peptides created by antigen processing are captured by specialised receptors present on all cells. These receptors are called HLA or histocompatibility molecules. This project examines the molecular events which mediate the capture of peptide antigens by HLA molecules. The main focus is on those peptide antigens which elicit killer T cell responses by the immune system. A knowledge of how these peptides are selected for presentation and how they are captured and carried to the cell surface is fundamental to understanding immune responses to microorganisms, tumours, allergens, transplants and self tissues as in autoimmunity. Therefore the study is of great general relevance.Read moreRead less
Assessing the ecosystem-wide risks of threatened species translocation. Assessing the ecosystem-wide risks of threatened species translocation. This project aims to develop the first quantitative risk assessment framework to improve decisions about moving threatened species to new places. Moving threatened plants and animals to new environments, or reintroducing them where they previously persisted, is a growing focus of conservation. Moving species can have unanticipated effects on other specie ....Assessing the ecosystem-wide risks of threatened species translocation. Assessing the ecosystem-wide risks of threatened species translocation. This project aims to develop the first quantitative risk assessment framework to improve decisions about moving threatened species to new places. Moving threatened plants and animals to new environments, or reintroducing them where they previously persisted, is a growing focus of conservation. Moving species can have unanticipated effects on other species in the ecosystem. Although the International Union for Conservation of Nature deems ecosystem-wide risk assessments essential for conservation translocations, no framework exists to assess these risks and inform these decisions. New tools for assessing the risks of conservation translocations are expected to improve global and local conservation outcomes.Read moreRead less
A novel top-down approach to ecosystem management using multivariate foraging strategies of an iconic marine top-predator. Understanding predator aggregation patterns in relation to marine productivity is critical in designing ecosystem-level conservation plans for protecting marine habitats and species. The project aims to develop a new approach to measure prey abundance and availability in the marine ecosystem for the management of resources of top-predators. This will be of specific benefit i ....A novel top-down approach to ecosystem management using multivariate foraging strategies of an iconic marine top-predator. Understanding predator aggregation patterns in relation to marine productivity is critical in designing ecosystem-level conservation plans for protecting marine habitats and species. The project aims to develop a new approach to measure prey abundance and availability in the marine ecosystem for the management of resources of top-predators. This will be of specific benefit in areas where a strong need exists for conservation of prey species with economic importance too low to justify expensive at-sea research.Read moreRead less
Cascading effects of Australia's ecological extinctions on biodiversity and ecosystem function. The current rate of species extinctions is so extensive that it has been described as the “sixth mass extinction”. In Australian ecosystems, extinctions and declines of mammals have been dramatic, with formerly abundant species now “ecologically extinct”, meaning they are too rare to continue to play important ecological roles. The loss of entire functional guilds may have cascading effects on biodive ....Cascading effects of Australia's ecological extinctions on biodiversity and ecosystem function. The current rate of species extinctions is so extensive that it has been described as the “sixth mass extinction”. In Australian ecosystems, extinctions and declines of mammals have been dramatic, with formerly abundant species now “ecologically extinct”, meaning they are too rare to continue to play important ecological roles. The loss of entire functional guilds may have cascading effects on biodiversity and ecosystem function. This project uses a multi-scalar experimental approach to investigate the broader impacts of mammal declines on Australian ecosystems, accounting for interactions with climate. The outcomes will include new insights into the pre-European state of Australian ecosystems and more realistic targets for ecosystem restoration.Read moreRead less
Ecohydrologic functioning of ephemeral streams. This project aims to increase understanding of how surface-groundwater interactions sustain vegetation associated with ephemeral streams. One of the biggest problems faced by mining and regional development in arid regions is how to protect ecological and heritage values of ephemeral streams by minimising impacts of water abstraction and surplus discharge. The project will use environmental tracers, coupled with assessment of vegetation water use a ....Ecohydrologic functioning of ephemeral streams. This project aims to increase understanding of how surface-groundwater interactions sustain vegetation associated with ephemeral streams. One of the biggest problems faced by mining and regional development in arid regions is how to protect ecological and heritage values of ephemeral streams by minimising impacts of water abstraction and surplus discharge. The project will use environmental tracers, coupled with assessment of vegetation water use and numerical modelling, to assess resilience of ephemeral streams to changes in flows resulting from mining activities and climate-related shifts in recharge. Expected outcomes of the project include providing appropriate context for evaluating and adapting management to conserve scarce water resources. This project should significantly contribute to the sustainable management of both mineral and groundwater resources.Read moreRead less
Vulnerability of Australian savannas to climate change and variability. Australian savannas are productive and are culturally and biologically significant landscapes, but they are vulnerable to climate change. This project will determine savanna function (carbon and water balance) for the present and assess how sensitive they have been to past climate variability. The project will then address how they may respond to future climate change.
Islands of rocks: geckos as a model system to understand patterns of biodiversity, endemism and speciation in the Kimberley. Australia is renowned for its diversity of lizards, yet a plethora of new "cryptic" gecko species continue to be discovered. The project will densely sample the complex Kimberley to understand the evolution of its geckos, which will shed light on true levels of species diversity and the geological and environmental history of this biodiversity hotspot.