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Web Based Study Of Risk Factors For Pain Exacerbation In Knee Osteoarthritis
Funder
National Health and Medical Research Council
Funding Amount
$408,501.00
Summary
While much is known about the risk factors for radiographic knee OA, the risk factors for symptoms emanating from joints affected by OA remain unclear. Identifying modifiable methods for alleviating pain and or avoiding risk factors for exacerbations of pain could have tremendous public health importance. In the proposed study we will use the Internet to facilitate data collection to test a set of risk factors for knee pain fluctuation among subjects with symptomatic radiographic knee OA.
Improving Outcomes In Low Back Pain: Identifying Risk Factors And Patient Subgroups
Funder
National Health and Medical Research Council
Funding Amount
$348,768.00
Summary
Low back pain is the leading cause of disability globally with no effective treatment. Although low back pain is a complex condition, current treatment strategies use a ‘one size fits all’ approach which has contributed to lack of effective treatments and patient’s dissatisfaction. This fellowship aims to identify novel risk factors, patient groups and patient specific factors related to poor outcomes so that effective treatments can be targeted to those most likely to benefit.
Does Low Dose Amitriptyline Reduce Pain In Knee Osteoarthritis? A Double Blind, Randomised, Pragmatic, Placebo Controlled Clinical Trial Of Amitriptyline In Addition To Usual Care
Funder
National Health and Medical Research Council
Funding Amount
$413,704.00
Summary
Pain is the main problem for people with osteoarthritis, a common form of arthritis. This pain is not controlled well. Pain comes from structural changes in the joint. However, after time, some people develop pain due to changes in the nervous system, called pain sensitisation. This is not affected by usual treatments. Amitriptyline is used to treat pain sensitisation. This study is a randomised trial to see whether amitriptyline, relieves pain in people with knee osteoarthritis over 3 months.
A Randomised Trial Of Krill Oil For Osteoarthritis Of The Knee
Funder
National Health and Medical Research Council
Funding Amount
$751,491.00
Summary
This study trials krill oil vs placebo, for painful knee osteoarthritis in people with joint swelling on MRI scans, to assess if krill oil reduces knee pain and knee swelling over 24 weeks. If krill oil can delay loss of knee cartilage through effects on cartilage and bone, this this could lead to a delay in the time to knee replacement surgery and improvements in quality of life for those suffering from OA.
Improving Awareness And Treatment Of Osteoarthritis
Funder
National Health and Medical Research Council
Funding Amount
$411,327.00
Summary
The foundation of this proposal leverages my current and planned program of osteoarthritis research to investigate the challenges of prevention, pain and delivery of care. These research initiatives are readily translatable, will make inroads into this prevalent and disabling disorder, have international impact and rely upon a close synergy between my research work and clinical practice.
From Imaging To Intervention In Osteoarthritis And Back Pain
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Osteoarthritis and back pain are regarded as cartilage disorders, however recent evidence suggests that underlying bone and joint fluid pathology are also involved. This project takes a unique approach of targeting bone and joint fluid pathology of knee osteoarthritis and back pain, and will test the effects of existing therapies and krill oil through clinical trials. If successful, it will have the potential to slow progression to joint replacement through an easy method of implementation.
DICKENS - A Randomised Controlled Trial Of DIaCerein To Treat KneE Osteoarthritis With EffusioN-Synovitis
Funder
National Health and Medical Research Council
Funding Amount
$1,327,836.00
Summary
Knee osteoarthritis (OA) is common, but the current treatments are poor. Almost 60% of people with knee OA have joint inflammation. Patients with inflammation are more likely to experience joint pain and rapid joint destruction. We propose that treating patients with inflammatory knee OA with the anti-inflammatory drug, diacerein, will reduce pain and joint damage.
A Randomised Trial Of Zoledronic Acid For Osteoarthritis Of The Knee
Funder
National Health and Medical Research Council
Funding Amount
$989,238.00
Summary
Osteoarthritis (OA) is the most common form of arthritis and is increasing markedly due to an ageing population. Despite its large disease burden, there are currently no approved disease-modifying drugs available which modify structural progression of OA. The aim of this study is to compare zoledronic acid treatment to placebo on knee structural change and knee pain over two years. It is hypothesised that zoledronic acid will reduce cartilage loss, knee pain, and bone marrow lesion size.
Improving Musculoskeletal Pain By Matching The Right Treatment With The Right Patient
Funder
National Health and Medical Research Council
Funding Amount
$437,034.00
Summary
Musculoskeletal pain is common, disabling, and costly in Australia. Current treatment options are poor. This program of research uses clinical trials to investigate new therapy options for osteoarthritis and chronic low back pain. These studies aim to provide new effective treatment options for patients that can improve pain, slow joint damage and decrease the overall burden of musculoskeletal disease.