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Pulmonary Hypertension In Chronic Obstructive Pulmonary Disease: Pulmonary Hyperinflation, Gas Trapping And Disproportionate Pulmonary Hypertension.
Funder
National Health and Medical Research Council
Funding Amount
$103,583.00
Summary
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality in Australia. Raised blood pressure in the lungs (pulmonary hypertension, PH) predicts a worse prognosis in patients with COPD. The mechanisms contributing to PH are incompletely understood. We aim to determine the role of lung hyperinflation in contributing to the development of PH in COPD. We also aim to identify a sub-group of patients that develop severe PH which may benefit from specific therapy.
Pulmonary Artery Pulsatility As A Predictor Of Survival Following Hospitalized Exacerbation Of Chronic Obstructive Pulmonary Disease
Funder
National Health and Medical Research Council
Funding Amount
$128,224.00
Summary
Many patients with Chronic Obstructive Pulmonary Disease (COPD) also have elevated lung blood pressures, or pulmonary hypertension (PH). Having both conditions increases the risk of death. It is difficult to diagnose PH in COPD. We will be using a new Computed Tomography (X-ray imaging) technique to investigate a marker of PH called ‘pulmonary artery pulsatility’. If PH can be diagnosed easily and accurately new treatments can be devised and researched potentially improving outcomes in COPD.
Physical Activity In Community Dwelling People With Chronic Obstructive Pulmonary Disease
Funder
National Health and Medical Research Council
Funding Amount
$107,204.00
Summary
Chronic obstructive pulmonary disease is a serious lung condition causing severe breathlessness. Participation in a pulmonary rehabilitation program can reduce symptoms and improve quality of life but is unavailable to most people who only see their local doctor. These studies will look at the effect of a new home-based pulmonary rehabilitation program on how much physical activity people do and the best ways to measure exercise ability at home.
Advanced Characteristics Of Chronic Obstructive Pulmonary Disease Exacerbations
Funder
National Health and Medical Research Council
Funding Amount
$122,714.00
Summary
Chronic Obstructive Pulmonary Disease is a lung disease that worsens over time. Flare-ups worsen lung function faster and patients may need hospital treatment. Virus infections cause half of these flare-ups. Large studies have not found a predictor other than a previous flare-up, having reflux and high blood white cell count. This study will examine the changes in lung function during a flare-up and recovery, and the effects of infection and reflux on lung function during a one year follow up.
Improving Health-related Quality Of Life In Patients Receiving Home Mechanical Ventilation
Funder
National Health and Medical Research Council
Funding Amount
$121,793.00
Summary
Home mechanical ventilation (HMV) is a treatment that assists someone to breathe using a machine. People may need HMV when their breathing has failed due to conditions such as chronic obstructive pulmonary disease (COPD), neuromuscular disease (NMD) or severe obesity. This project will examine the quality of life of patients receiving HMV in Australia and Canada. It will also determine if we can improve the treatment by using a sleep study to monitor breathing when patients first start HMV.
Adaptive Immunity To Non-typeable H. Influenzae In Children With Bronchiectasis
Funder
National Health and Medical Research Council
Funding Amount
$81,143.00
Summary
Bronchiectasis is a chronic disease of the lungs which affects at least 1 in 68 NT Indigenous children. It causes recurring lung infections, hospitalisations and deteriorating lung function. This study will provide important data on the immune response of Indigenous children to NTHi, the most important pathogen associated with chronic respiratory infections and why this immune response is not protective. This is the first step in targeting therapies to the prevention of bronchiectasis.
The Menstrual Cycle, Menopause And Gender Specific Health Needs Of Women With Complex Medical And Psychiatric Conditions.
Funder
National Health and Medical Research Council
Funding Amount
$149,982.00
Summary
The great advances in medical science mean that women are living longer, sometimes with very complex conditions.The aim of this study is to determine how common women’s health issues are in women who have had a lung or bone marrow transplant and in women with severe mental illness. The study will involve face to face interview with women and then a survey of a larger number of women. The study will help improve the care and quality of life of women who already face significant health challenges.
Lung Cancer Screening With Low Dose Computed Tomography (LDCT); Exploring Opportunities To Optimise Disease Prevention Across A Range Of Health Outcomes In Australia.
Funder
National Health and Medical Research Council
Funding Amount
$132,743.00
Summary
Lung cancer is the largest cause of cancer related death in the world. Low dose computed tomography (LDCT) is a scan that reduces deaths from lung cancer by detecting early disease. Australia is investigating a national screening program with LDCT. This project evaluates opportunity provided by such a program to develop a personalised approach to screening using information provided by LDCT beyond cancer (e.g. heart and bone disease) and modify risk factors (e.g. physical activity and smoking).
Advancing The Knowledge, Understanding And Management Of Respiratory Exacerbations In Children With Bronchiectasis
Funder
National Health and Medical Research Council
Funding Amount
$71,359.00
Summary
Bronchiectasis is a condition which causes significant morbidity, burden of disease and mortality in children as well as adults. Exacerbations in bronchiectasis influence the decline in lung function and quality of life for patients. Although the importance of treating exacerbations effectively is well accepted, there are no universally accepted guidelines for recognizing and managing an exacerbation of bronchiectasis in children. This study aims to fill this clinical and research gap.
Activating Primary Care COPD Patients With Multi-morbidity (APCOM) Pilot Project
Funder
National Health and Medical Research Council
Funding Amount
$78,309.00
Summary
The Activating Primary Care COPD Patients with Multi-morbidity (APCOM) pilot project aims to empower primary care patients with chronic obstructive pulmonary disease and other co-existing chronic conditions. This will be done by means of a tailored, practice nurse-delivered, self-management intervention designed to improve the participants' disease awareness and coping skills.