The Analgesic Evaluation Of Novel Natural Products From The Australian Plant Barringtonia Acutangula
Funder
National Health and Medical Research Council
Funding Amount
$174,500.00
Summary
This project aims to evaluate the analgesic activity of several novel natural products that have been isolated from the Australian plant Barringtonia acutangula. An Australian Aboriginal tribe have been known to use B. acutangula aqueous bark extracts for its analgesic properties. Griffith University researchers have confirmed this biological activity in the crude aqueous bark extract. A large scale extraction and isolation process will obtain the novel compounds in sufficient quantities that wi ....This project aims to evaluate the analgesic activity of several novel natural products that have been isolated from the Australian plant Barringtonia acutangula. An Australian Aboriginal tribe have been known to use B. acutangula aqueous bark extracts for its analgesic properties. Griffith University researchers have confirmed this biological activity in the crude aqueous bark extract. A large scale extraction and isolation process will obtain the novel compounds in sufficient quantities that will allow for their pharmacological evaluation as potential analgesic drugs.Read moreRead less
Trauma-focused CBT & Exercise For Chronic Whiplash: Addressing All Aspects Of A Chronic Condition
Funder
National Health and Medical Research Council
Funding Amount
$673,562.00
Summary
Chronic pain following whiplash injury is common and incurs substantial personal and economic costs. There are few effective treatments available. Recent research has shown that many people with chronic whiplash also have symptoms of posttraumatic stress. This study will investigate whether combining an intervention aimed at decreasing posttraumatic stress with exercise will decrease pain and disability in people with chronic whiplash
Spinal complaints present the greatest social and economic burden of musculoskeletal conditions in Australia. This reflects current realities: the cause remains unknown; 80% of the population is affected; and isolated professions perform a staggering array of interventions. The CCRE aims to target these realities and improve Australia's capacity to prevent and manage spinal disorders by supporting innovative interdisciplinary research and training. This community- and university-based centre wil ....Spinal complaints present the greatest social and economic burden of musculoskeletal conditions in Australia. This reflects current realities: the cause remains unknown; 80% of the population is affected; and isolated professions perform a staggering array of interventions. The CCRE aims to target these realities and improve Australia's capacity to prevent and manage spinal disorders by supporting innovative interdisciplinary research and training. This community- and university-based centre will align highly successful clinical and basic researchers in collaboration with a national network of spine scientists to foster interdisciplinary clinical researcher training, develop new diagnostics and therapeutics, and translate findings to the community. Through clinical research the centre aims to: (i) Advance understanding of physiology and pathophysiology of spinal pain (ii) Translate findings from basic research to clinical practice (iii) Establish coordinated multidisciplinary research to reduce the burden of spinal pain (iv) Predict and prevent the transition from acute to chronic states (v) Train a new generation of transdisciplinary clinical scientists (vi) Rapidly assess new treatment possibilities in pre-clinical studies (vii) Develop innovative technologies for diagnostics and therapeutics (viii) Encourage Australian commercialisation opportunities for new discoveries (ix) Encourage community-user participation in direction of research programs (x) Disseminate new findings and information of evidence-based practice to patients, clinicians, insurers, government and the scientific and wider communityRead moreRead less
Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
Novel Insights Into The Mechanisms Of How Chikungunya Virus Cause Disease In Humans
Funder
National Health and Medical Research Council
Funding Amount
$554,808.00
Summary
Many of the most dangerous and easily transmitted infectious agents are viruses. The emergence of chikungunya virus globally and the recognition of this pathogen in the aetiology of chronic diseases show the need for a better understanding of how the virus cause disease. The expected outcomes are a better understanding of human alphaviral diseases, with a view to improving prevention and treatment strategies to reduce the disease burden of CHIKV and related viruses.
Workplace Interventions To Reduce The Cost Of Neck Problems In Office Personnel
Funder
National Health and Medical Research Council
Funding Amount
$660,834.00
Summary
Neck pain in office workers is a major burden in industry in terms of lost productivity and personal suffering. This research will evaluate a novel intervention for the prevention and management of neck pain in computer users. The impact and value of neck specific exercises and best practice office ergonomics will be evaluated from the employers (productivity loss) and workers perspective (severity of neck pain). The findings will directly benefit future management of this significant health iss ....Neck pain in office workers is a major burden in industry in terms of lost productivity and personal suffering. This research will evaluate a novel intervention for the prevention and management of neck pain in computer users. The impact and value of neck specific exercises and best practice office ergonomics will be evaluated from the employers (productivity loss) and workers perspective (severity of neck pain). The findings will directly benefit future management of this significant health issue.Read moreRead less
Glycotherapeutics; A New Class Of Treatment For Alphavirus-induced Musculoskeletal Disease
Funder
National Health and Medical Research Council
Funding Amount
$449,868.00
Summary
The hallmark of alphavirus disease is crippling pain and joint arthritis, which often has an extended duration. Currently there is no licenced specific treatment for alphavirus disease and the increasing spread of infection highlights an urgent need for therapeutic intervention strategies. This grant looks at the potential of pentosan polysulfate as a promising drug-repurposing candidate for the treatment of alphavirus-induced arthritis.
Inhibition Of Interferon-?/? Induction By Ross River Virus
Funder
National Health and Medical Research Council
Funding Amount
$589,664.00
Summary
Ross River virus is a mosquito-borne virus that causes arthritis in the joints of many people infected. This project will look at the early interactions of a virulent virus with the mammalian host that appear to enable the virus to replicate and spread in the host and thereby cause disease. These interactions are with the host interferon protein which the virus has developed the ability to inhibit. The effect of the invading virus on the host's interferon system, part of the immune system, will ....Ross River virus is a mosquito-borne virus that causes arthritis in the joints of many people infected. This project will look at the early interactions of a virulent virus with the mammalian host that appear to enable the virus to replicate and spread in the host and thereby cause disease. These interactions are with the host interferon protein which the virus has developed the ability to inhibit. The effect of the invading virus on the host's interferon system, part of the immune system, will be examined.Read moreRead less