HMGB1: A Novel Player In The Pathogenesis Of Inflammatory Myositis?
Funder
National Health and Medical Research Council
Funding Amount
$84,800.00
Summary
The project aims to determine whether HMGB1, a pro-inflammatory molecule, plays a key role in the cause of inflammatory myositis, an extremely disabling muscle condition characterised by progressive weakness.
Systemic lupus erythematosus (SLE) is a condition which causes inflammation in many different organs and can lead to significant suffering and death. Glucocorticoids (GC) are very good at controlling inflammation, however they have severe side effects such as diabetes and bone thinning, and cannot be used long term. This project aims to investigate a protein “GILZ” in patients with SLE. GILZ may have similar anti-inflammatory effects to GC but may not be associated with the same side effects.
Inflammatory skin disorders, such as psoriasis and dermatitis, are responsible for a large burden of human disease and affect people across alldemographics. Knockout (KO) of TNF signalling members in mice is known to induce skin inflammation. This project proposes to use these genetic mouse models to investigate how and why disruption of particular TNF superfamily members leads to disease and potentially identify new targets for treatment.
Assessment Of Non-communicable Diseases And Associated Risks Among Indonesian Adolescents
Funder
National Health and Medical Research Council
Funding Amount
$128,224.00
Summary
Adolescents experience a significant burden of disease from preventable non-communicable diseases (NCDs) and several risk factors for later development of NCDs are potentially modifiable during adolescence. In Indonesia, limited data measuring NCD risk factors, prevalence and outcomes in adolescents contributes to a policy and practice gap. This study aims to explore the burden of NCDs experienced by Indonesian adolescents and examine opportunities for health system change.
Calcification of the arteries is a ubiquitous finding in patients with end stage renal failure. It is often mirrored by disturbed bone metabolism. Increasing evidence suggests a close relationship between bone and vascular health. This study aims to determine the role of calciprotein particles as a mediator of calcification in bones and arteries. Translating these findings to renal patients will ultimately contribute to providing a scientific basis for developing treatment for these patients.
Alice Springs Hospital Readmission Prevention Project
Funder
National Health and Medical Research Council
Funding Amount
$124,608.00
Summary
The Alice Springs Hospital Readmission Project is a collaboration between Alice Springs Hospital and the Baker IDI in Central Australia. Recurrent readmissions can lead to hospital overcrowding and remove a person from their community. The project will investigate whether a tailored discharge planning and case management approach for adult patients with complex chronic disease is beneficial in reducing recurrent readmissions to hospital and facilitating engagement with primary care services.
Chronic Kidney Disease And Cardiovascular Disease In Aboriginal Children And Young Adults
Funder
National Health and Medical Research Council
Funding Amount
$111,232.00
Summary
Aboriginal Australians are burdened with a higher level of chronic kidney disease and cardiovascular disease, which is the greatest contributor to the gap in health between Aboriginal and non-Aboriginal Australians. My proposed research aims identify if the increased risk of chronic disease is evident during childhood and adolescence amongst Aboriginal Australians, and to explore if this inequity is largely explained by the social determinants of health.
Determinants Of Outcomes In SLE: Impact Of Models Of Care, Socioeconomic Factors And Biologic Variables In A Multiethnic Australian Population
Funder
National Health and Medical Research Council
Funding Amount
$134,124.00
Summary
Lupus is a chronic disease where the immune cells attack multiple systems in the body, which can lead to severe organ damage and even death. It is known that genes, socioeconomics and models of care all individually influence the outcomes in lupus. The exact contribution of each one is poorly understood, because they are studied in isolation. This project will take an integrated approach to investigating the factors that influence outcomes in lupus, looking for potentially addressable effects.
The Menstrual Cycle, Menopause And Gender Specific Health Needs Of Women With Complex Medical And Psychiatric Conditions.
Funder
National Health and Medical Research Council
Funding Amount
$149,982.00
Summary
The great advances in medical science mean that women are living longer, sometimes with very complex conditions.The aim of this study is to determine how common women’s health issues are in women who have had a lung or bone marrow transplant and in women with severe mental illness. The study will involve face to face interview with women and then a survey of a larger number of women. The study will help improve the care and quality of life of women who already face significant health challenges.
Improving Health-related Quality Of Life In Patients Receiving Home Mechanical Ventilation
Funder
National Health and Medical Research Council
Funding Amount
$121,793.00
Summary
Home mechanical ventilation (HMV) is a treatment that assists someone to breathe using a machine. People may need HMV when their breathing has failed due to conditions such as chronic obstructive pulmonary disease (COPD), neuromuscular disease (NMD) or severe obesity. This project will examine the quality of life of patients receiving HMV in Australia and Canada. It will also determine if we can improve the treatment by using a sleep study to monitor breathing when patients first start HMV.