Ion Channel Dysfunction In The Pathophysiology Of Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome: Diagnostic Biomarkers, Therapeutic Targets And Treatments
Funder
National Health and Medical Research Council
Funding Amount
$1,460,700.00
Summary
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is an illness affecting up to 240,000 Australians. The cause of ME/CFS is not known, and there are currently no diagnostic tests or effective treatments. Research suggests that ion channels that transfer calcium within cells are dysfunctional in ME/CFS. Our research will investigate ion channels and calcium transfer using immune cells to help develop biomarkers for the illness and discover better treatments for these patients.
Exploring The Role Of Nitrogen Metabolism, Energy Metabolism And Mitochondrial Function In The Pathophysiological Mechanisms Of Paediatric ME/CFS.
Funder
National Health and Medical Research Council
Funding Amount
$784,064.00
Summary
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a disease diagnosed by symptoms. Our extensive research has led to a hypothesis that ME/CFS results from toxic by-products of energy production in their cells. This problem can be caused by many unique ways, which could explain the diversity of the ME/CFS patient population. We propose to test this hypothesis with a novel personalised experimental design to simultaneously produce a plethora of new knowledge for the field of ME/CFS.