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Biomarkers For The Progression Of Cholangiocarcinoma
Funder
National Health and Medical Research Council
Funding Amount
$507,347.00
Summary
Cholangiocarcinoma (CCA) is a form of liver cancer with a devastatingly poor prognosis. In East Asia long term infection with a parasitic worm leads to CCA. Because it is feasible to monitor the development of CCA from the time of infection with the parasite, we propose a biomarker discovery program using CCA samples from liver fluke infected persons in Thailand. This will eventuate in tools for the early diagnosis and early treatment of CCA for those at risk of developing this cancer globally.
Novel Precision-based Treatments For Biliary Tract Cancer
Funder
National Health and Medical Research Council
Funding Amount
$644,241.00
Summary
Advanced biliary tract cancer has a median life-expectancy of ~12 months. The relatively low incidence of the disease in Australia requires a collaborative team-based approach to drive progress. To achieve this, we have established a multidisciplinary research team based in Australia, Thailand and Japan. Here, we will now build on our exciting preliminary discoveries to test new patient-specific treatments, and develop methods to efficiently identify patients who may respond to immunotherapy.
Proteomic Approaches To Explore The Pathogenesis And Secretomes Of Parasitic Flukes Of Humans
Funder
National Health and Medical Research Council
Funding Amount
$415,320.00
Summary
Ten percent of the human population are at risk of infection with liver, blood and lung flukes. These parasites cause considerable human morbidity and mortality including a strong association with cancer of the bile ducts. Current control efforts rely on drugs, but, reinfection and resistance are a problem. This research is aimed at understanding how these parasites cause disease (particularly how a parasite causes cancer) and the development of vaccines and new drugs.
Secreted Exosome-like Vesicles From The Carcinogenic Liver Fluke
Funder
National Health and Medical Research Council
Funding Amount
$771,543.00
Summary
Parasitic liver flukes secrete microscopic cell-like vesicles into the bile ducts when feeding on infected humans. These vesicles, called exosomes, are taken up by the cells lining the bile ducts and promote them to become pre-cancerous. We will characterise the contents of these fluke exosomes and identify the key molecules on their surfaces that can be used to prevent exosome uptake by cells and ultimately form the basis of a vaccine that prevents fluke infection and subsequent liver cancer.