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It remains unclear what the causes of schizophrenia and other psychotic disorders are and what the most effective interventions are for preventing onset of disorder in those at risk. The current research program consists of a number of interrelated studies of how psychosis develops, the most effective sequential treatments to prevent the onset of disorder in high risk young people, and testing clinical criteria to identify young people at risk of a range of serious mental illnesses.
Developing Innovative Pathways For The Prevention Of Lifelong Cardiovascular Risk
Funder
National Health and Medical Research Council
Funding Amount
$753,300.00
Summary
My research aims to develop better ways to predict the risk of heart disease, better approaches to disease prevention and treatment and to ultimately develop more effective approaches to implementing these strategies into health care delivery.
A/Prof Thomas' Senior Research Fellowship will provide support for the continued development of a broad-based, national and international research program focused on the biology and clinical aspects of connective tissue tumours. A/Prof Thomas' career goals are to continue work in basic, translational and clinical research into these tumours which include osteosarcoma, liposarcoma, giant cell tumour of bone and the inherited risk of development of these neoplasms.
The three interlocking aims of this fellowship are to address the contribution of specific genes to melanoma development in: (i) families (ii) the general population (iii) tumour progression. The findings will be used to develop better models to predict which individuals in the population are at greatest risk of melanoma and to identify molecular targets for the design of new therapies to treat this disease.
Novel Therapies, Risk Pathways And Prevention Of Mood Disorders
Funder
National Health and Medical Research Council
Funding Amount
$863,413.00
Summary
Concordant with the NHMRC priorities, this fellowship will principally focus on the development of novel therapies for mood disorders. We have pilot data that the amino acid, N acetyl cysteine reduces symptoms in unipolar and bipolar disorder and schizophrenia. We will further delineate the spectrum of efficacy, mechanisms of action and tolerability profile of this and related agents. We also will study risk factors and pathways for the development of depression, to develop public health strateg ....Concordant with the NHMRC priorities, this fellowship will principally focus on the development of novel therapies for mood disorders. We have pilot data that the amino acid, N acetyl cysteine reduces symptoms in unipolar and bipolar disorder and schizophrenia. We will further delineate the spectrum of efficacy, mechanisms of action and tolerability profile of this and related agents. We also will study risk factors and pathways for the development of depression, to develop public health strategies.Read moreRead less
In autoimmune diseases the immune system attacks the body’s own tissues. Although we know that both genetic and environmental factors contribute to the risk of disease, identifying these genes and the environmental factors involved is very difficult. Furthermore, we have almost no idea how these factors interact with each other, something we need to understand in order to predict the risk of disease and reliably identify possible therapies. These are the aims of this fellowship.
Clinically Severe Obesity: A Better Understanding Of A Complex Condition, Improving Health Outcomes Through Effective Therapies, And Delivering A Comprehensive Clinical Pathway.
Funder
National Health and Medical Research Council
Funding Amount
$701,539.00
Summary
Clinically severe obesity impacts on the health of 7-8% or 1.5 million Australians, yet poor access to integrated effective care. This challenging area of healthcare is distorted by perceptions and beliefs that are frequently contrary to clinical and physiological research findings. Professor Dixon’s plan is to: 1) To learn more about clinically severe obesity, 2) improve the assessment and delivery of effective care, and 3) improve clinical capacity to better care for these Australians.
Professor Whiteman is a medical epidemiologist with interests in the causes, prevention and treatment of cancer. His fellowship will be directed towards research focussing on methods for controlling cancers of the skin and oesophagus.
Professor Paul Baird specialises in identifying and understanding how genetic changes associated with common eye diseases including age-related macular degeneration and keratoconus lead to vision loss and blindness. This fellowship will allow him to uncover novel genetic contributors in these diseases using next-generation molecular techniques. He will assess functionality of these variants, allowing him to translate these findings back to the clinic allowing personalised treatment options.
We recently established the Centre for Neurogenetics and Statistical Genomics, a research centre within the Queensland Brain Institute. It was established to bring together a team of researchers with expertise in neurogenetics, neuropsychiatric genetics, statistical genomics and computational biology. During my Fellowship I will conduct research at this Centre to elucidate the genetic basis of neurogenetic diseases and psychiatric disorders, using genomic tools and data analysis.