Role Of IGF Binding Protein-3 (IGFBP-3) And IGFBP-5 As Modulators Of Nuclear Hormone Signalling
Funder
National Health and Medical Research Council
Funding Amount
$465,750.00
Summary
The insulin-like growth factors are small proteins involved in the growth of most tissues. Their actions are regulated by binding to larger proteins (known as IGFBPs) in the bloodstream and outside the cell. However, some IGFBPs are also found inside cells, where they seem to carry out other functions. We believe that two of these binding proteins, IGFBP-3 and IGFBP-5, change the way cells respond to vitamin A and vitamin D. These two vitamins are important in cell growth and in the way certain ....The insulin-like growth factors are small proteins involved in the growth of most tissues. Their actions are regulated by binding to larger proteins (known as IGFBPs) in the bloodstream and outside the cell. However, some IGFBPs are also found inside cells, where they seem to carry out other functions. We believe that two of these binding proteins, IGFBP-3 and IGFBP-5, change the way cells respond to vitamin A and vitamin D. These two vitamins are important in cell growth and in the way certain cells perform specialised functions. In test-tube experiments, IGFBP-3 and IGFBP-5 interact directly with the receptors that regulate the effects of these hormones. If the same thing happens inside the cell, IGFBP-3 and IGFBP-5 could change the way these receptors respond to signals from outside the cell. We will investigate what effect these IGFBPs have in living cells and in whole animals and how this may relate to human disease. If we are able to understand how IGFBP-3 and IGFBP-5 affect the way cells respond to vitamin A and D, then we may be able to develop new ways to treat certain human diseases.Read moreRead less
Child health and developmental inequities: Evidence for precision policy. The project aims to use cutting edge analytic approaches applied to existing data to identify how policy interventions related to parents’ mental health, preschool programs, and the built environment can be optimised to reduce inequities in children’s mental, academic, and physical health outcomes. The project will be informed by our partners and advisers from across government portfolios and service delivery, ensuring tha ....Child health and developmental inequities: Evidence for precision policy. The project aims to use cutting edge analytic approaches applied to existing data to identify how policy interventions related to parents’ mental health, preschool programs, and the built environment can be optimised to reduce inequities in children’s mental, academic, and physical health outcomes. The project will be informed by our partners and advisers from across government portfolios and service delivery, ensuring that the evidence generated has contemporary policy relevance. The project expects to identify clear and actionable policy pathways to reduce child inequities in Australia, which can benefit decision makers by helping them to direct limited public funds towards intervention opportunities that will have the greatest impact.Read moreRead less
The Kids in Communities Study: national investigation of community level effects on children's developmental outcomes. This project (a cross-disciplinary collaboration) will investigate community level factors influencing early childhood developmental outcomes using a mixed methods approach in up to 10 communities across Australia. This will result in a potential set of measures or indicators that reflect communities that are good for children.
A study investigating the feasibility of implementing a national approach to child and family health services. Understanding and strengthening the way in which universal health services are provided to pregnant women, children and families has the potential to impact over a million Australian families annually. The findings of this study will have national application as federal, state and territory governments work towards implementing a national approach to child and family health services. Th ....A study investigating the feasibility of implementing a national approach to child and family health services. Understanding and strengthening the way in which universal health services are provided to pregnant women, children and families has the potential to impact over a million Australian families annually. The findings of this study will have national application as federal, state and territory governments work towards implementing a national approach to child and family health services. The findings will inform effective multidisciplinary collaboration and service integration, address service gaps and duplication and lead to increased access to services. This study will generate new knowledge about characteristics of organisations, service delivery and professions that facilitate or hinder innovation.Read moreRead less
Cluster randomised control trial of an early childhood literacy intervention to improve literacy and language outcomes in preschool aged children. Reading failure disproportionately affects disadvantaged communities in Australia, with nearly 40% of poor children failing to read at the minimum reading benchmark in Grade three. Of more concern is the disturbing trend indicating that prior to first grade, socioeconomic status (SES) differences also exist in important antecedents of reading such as ....Cluster randomised control trial of an early childhood literacy intervention to improve literacy and language outcomes in preschool aged children. Reading failure disproportionately affects disadvantaged communities in Australia, with nearly 40% of poor children failing to read at the minimum reading benchmark in Grade three. Of more concern is the disturbing trend indicating that prior to first grade, socioeconomic status (SES) differences also exist in important antecedents of reading such as letter knowledge and phonological processing skills, yet there remains no universal program to promote early language and literacy practices in the primary care setting. We propose a cluster randomised controlled trial to evaluate the efficacy of a multi injection intervention to improve literacy outcomes of children in disadvantaged communities.Read moreRead less
Scalability Of The Transform-Us! Program To Promote Children's Physical Activity And Reduce Prolonged Sitting In Victorian Primary Schools
Funder
National Health and Medical Research Council
Funding Amount
$549,823.00
Summary
Transform-Us! is an innovative primary school program that has been found to substantially increase children’s physical activity levels, reduce sitting time and benefit health. With simple changes to the school and classroom environments and teaching practices (eg, standing lessons) we will work with partners in the education and health systems to translate this program across Victorian primary schools to determine the real-world implementation and impact of this program over 5 years.
Promoting healthy eating, active play and sustainability awareness in early childhood curricula: Addressing the Ben10™ problem. A pedagogical communication strategy has been developed to allow early childhood educators to design curriculum interventions that support children’s learning about healthy eating, the importance of active play and the sustainability consequences of their food and toy selections. The aim of this study is to conduct a randomised trial to evaluate the efficacy of the curr ....Promoting healthy eating, active play and sustainability awareness in early childhood curricula: Addressing the Ben10™ problem. A pedagogical communication strategy has been developed to allow early childhood educators to design curriculum interventions that support children’s learning about healthy eating, the importance of active play and the sustainability consequences of their food and toy selections. The aim of this study is to conduct a randomised trial to evaluate the efficacy of the curriculum interventions, developed by teachers using this pedagogical communication strategy, on children’s knowledge about healthy eating, active play and the sustainability consequences of their food and toy selections. This project connects strongly with the learning outcomes of the National Early Years Learning Framework and the Australian Curriculum to be implemented in 2014.Read moreRead less
ARC Centre of Excellence for the Digital Child. Our vision is for Australian children to be healthy, educated and connected. This Centre will integrate child health, education, and digital and social connectedness, innovating across disciplines to meet Australia’s ongoing challenges of supporting young children growing up in a rapidly changing digital age. The Centre’s world-leading team investigates children’s digital practices through three interconnected research programs supported by a longi ....ARC Centre of Excellence for the Digital Child. Our vision is for Australian children to be healthy, educated and connected. This Centre will integrate child health, education, and digital and social connectedness, innovating across disciplines to meet Australia’s ongoing challenges of supporting young children growing up in a rapidly changing digital age. The Centre’s world-leading team investigates children’s digital practices through three interconnected research programs supported by a longitudinal family cohort study and children’s technology laboratories. The Centre will address tensions in a contested field to inform government and non-government policy, technology innovation, and develop programs and guidelines for children, families, educators and technology developers. Read moreRead less
Improving Delivery Of Secondary Prophylaxis For Rheumatic Heart Disease: A Stepped-wedge, Community-randomised Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,913,074.00
Summary
Rheumatic heart disease (RHD) is a major health problem in Indigenous communities. Continued progress in controlling RHD requires an understanding of how to improve delivery of regular injections of penicillin - secondary prophylaxis (SP). We will evaluate a systems-based approach to improving delivery of SP, using a stepped-wedge trial in 12 communities in NT and Qld. If successful, this model will provide a practical and transferable model.