Investigating Autism Spectrum Disorder: Causes And Efficacious Interventions
Funder
National Health and Medical Research Council
Funding Amount
$705,501.00
Summary
Autism Spectrum Disorder (ASD) is a growing public health concern, but we know little about the causes nor treatments for the condition. During the period of this Fellowship I will seek to make significant inroads into these unknowns, by performing large-scale international research into the genetic, biochemical and neurological causes of ASD, and conducting a series of clinical treatment trials in collaboration with research groups from across the world.
I am an epidemiologist using high quality data collections and novel methods to generate new knowledge that will help reduce the impact or prevalence of birth defects and related disability.
Bone Growth For Healthy Development: Physiology, Pathophysiology, And Regeneration
Funder
National Health and Medical Research Council
Funding Amount
$621,458.00
Summary
Musculoskeletal damage is a major burden on individuals and our health care system. My research program will focus on improving bone health in three important areas: (1) children’s growth plate injury and growth defects; (2) bone loss and bone marrow defects from cancer chemotherapy; (3) ensuring that bone grows healthily in early life. The overall intent of this research is to develop new therapies when bone doesn’t grow well, or is damaged.
Improving Outcomes In Pregnancies Complicated By Asthma: Understanding Mechanisms And Defining Interventions
Funder
National Health and Medical Research Council
Funding Amount
$707,370.00
Summary
Asthma is a common disease to complicate pregnancy and it is important to identify ways of effectively managing the disease to ensure the fetus has the best possible outcome. The current research focusses on this disease and looks at ways of improving management in pregnancy and improving outcomes for the baby.
Early Childhood Mental Health: Pathways, Treatment, Access, And Community Literacy.
Funder
National Health and Medical Research Council
Funding Amount
$849,540.00
Summary
Many causes, warning signs, and opportunities for intervention for mental health problems are evident in early childhood. This project will conduct research and innovative practice that will transform our understanding of mental health problems in early childhood, including improved understanding of the environmental/biological mechanisms, methods to best target and disseminate effective early intervention, and improve community literacy and reduce stigma for these children and their parents.
Dr Gilchrist is a reproductive biologist studying factors that regulate the intrinsic quality of unfertilised eggs. He has developed a new form of hormone-free infertility treatment which he will test in a clinical trial over the next 5 years.
My major goal for the past 20 years has been to understand how hormones such as gastrin stimulate the development of gastrointestinal cancer. One approach has been to define the intracellular signalling pathways by which gastrins enhance cell growth. Our discovery that iron is essential for the biological activity of gastrins may allow the development of novel therapies for colon cancer and iron overload.
Innovative Methods For Assessing And Intervening On Children’s Sedentary Behaviour And Health
Funder
National Health and Medical Research Council
Funding Amount
$745,823.00
Summary
Very little is known about the independent health consequences of time spent sitting among children. This is in part because of the challenges of assessing these behaviours. In addition, evidence of the effectiveness of strategies to reduce children’s sitting time is lacking. This fellowship will use cutting-edge techniques to objectively assess children’s sitting time and will also examine the effectiveness of interventions to reduce sitting time and promote health.
Therapeutic Targeting Of Ribosome Biogenesis In Cancer And Ribosomopathies
Funder
National Health and Medical Research Council
Funding Amount
$763,845.00
Summary
My fellowship application will build on my international leadership in understanding growth control in human disease. My vision is to uncover the molecular mechanisms governing the loss of normal control of the synthesis of the molecular machines, termed ribosomes, that are responsible for synthesising all cell proteins. I will translate these findings into new paradigms to treat patients suffering from diseases such as cancer and ribosomopathies, that are associated with ribosome dysfunction.
Addressing Evidence-practice Gaps To Improve Maternal And Child Health Outcomes In Vulnerable Populations
Funder
National Health and Medical Research Council
Funding Amount
$622,655.00
Summary
The overall goal of this fellowship program is to contribute to ‘closing the gap’ in maternal and child health outcomes in Indigenous, refugee and other vulnerable and socially disadvantaged population groups by working at the interface of policy, health services and community to co-design and implement policy-relevant research needed to achieve sustained improvements in maternal and child health outcomes.