Assessment Strategies, Treatments And Risk Factors In Neuropathy And Neuromuscular Disease
Funder
National Health and Medical Research Council
Funding Amount
$437,034.00
Summary
Neuropathy and neuromuscular disorders provide a major public health challenge. My research efforts are targeted at improving strategies to assess neuropathy and neuromuscular disease, measuring the impact of disease and translating these approaches into clinical trials and clinical practice. The project will identify the best assessment strategies for early detection of nerve damage, determine the impact of nerve disorders in Australia and determine how best to address these disorders.
Analysis Of Apoptotic Pathways To Develop Better Therapies For Unresponsive Cancers.
Funder
National Health and Medical Research Council
Funding Amount
$130,807.00
Summary
Tight control of the balance between cellular survival and death is important for normal development and to avoid numerous diseases. Inappropriate survival of precancerous cells can contribute to oncogenesis. Anti-cancer therapies act by inducing a cellular self-destruct program in tumour cells, and blocks in pathways controlling this process can lead to resistance to anti-cancer treatments. Defining cell death pathways will enable the development of better therapies for incurable cancers.
Preserving Ovarian Function During Chemotherapy And Old Age
Funder
National Health and Medical Research Council
Funding Amount
$425,048.00
Summary
Chemotherapy treatment and the natural ageing process leads to ovarian failure and infertility. For young cancer survivors, chemotherapy induced infertility is devastating, and like aged women, leads to hormonal changes that lead to osteoporosis, diabetes, obesity, and neurodegeneration. Here, a new class of molecules will be tested for their ability to prevent and reverse infertility folllowing chemotherapy treatment, and in old age. These findings will improve the healthy lifespan of women.