Integrated nonmetal-metal single-atom catalysis for selective synthesis. Single atom catalysts can achieve the maximum efficiency of active sites for a reaction. This project will develop integrated nonmetal and metal single atom-based catalysts for selective oxidation towards clean production and organic waste conversion to value-added polymers for carbon recycle. The project will result in new functional materials and green catalytic processes for chemical synthesis and waste reduction, and ad ....Integrated nonmetal-metal single-atom catalysis for selective synthesis. Single atom catalysts can achieve the maximum efficiency of active sites for a reaction. This project will develop integrated nonmetal and metal single atom-based catalysts for selective oxidation towards clean production and organic waste conversion to value-added polymers for carbon recycle. The project will result in new functional materials and green catalytic processes for chemical synthesis and waste reduction, and advance fundamental understanding of molecular structure of materials for catalyst design and process engineering for industrial applications. The outcomes will promote the development of chemical industry, waste recycle and green environment in Australia, making significant benefits to economics and society.Read moreRead less
Asymmetric Synthesis and Biological Evaluation of Bioactive Alkaloids and their Analogues. We propose to develop innovative methods for preparing bioactive natural products and their analogues with potential applications as new and safer therapeutic drugs and agricultural chemicals. This project would make important scientific contributions to the advancement of the fundamentals of synthetic organic chemistry and contribute to Australia's development as a knowledge-based economy. The methodolo ....Asymmetric Synthesis and Biological Evaluation of Bioactive Alkaloids and their Analogues. We propose to develop innovative methods for preparing bioactive natural products and their analogues with potential applications as new and safer therapeutic drugs and agricultural chemicals. This project would make important scientific contributions to the advancement of the fundamentals of synthetic organic chemistry and contribute to Australia's development as a knowledge-based economy. The methodology and products developed may have potential pharmaceutical and agricultural applications from which the country could benefit from in the future. This project would help developed skilled people that may develop innovative outcomes in the future, especially in the developing pharmaceutical and biotechnology industries in Australia.Read moreRead less
Stereoselective Synthesis of Bioactive Alkaloids for Structure Elucidation and Drug Discovery. It is proposed to develop innovative methods for preparing bioactive natural products and their analogues with potential applications as new and safer therapeutic drugs and agricultural chemicals. This project would make important scientific contributions to the advancement of the fundamentals of synthetic organic chemistry and contribute to Australia's development as a knowledge-based economy. The m ....Stereoselective Synthesis of Bioactive Alkaloids for Structure Elucidation and Drug Discovery. It is proposed to develop innovative methods for preparing bioactive natural products and their analogues with potential applications as new and safer therapeutic drugs and agricultural chemicals. This project would make important scientific contributions to the advancement of the fundamentals of synthetic organic chemistry and contribute to Australia's development as a knowledge-based economy. The methodology and products developed are likely to have potential pharmaceutical and agricultural applications from which the country could benefit in the future. This project will train skilled people who may develop innovative outcomes in the future, especially in the developing pharmaceutical and biotechnology industries in Australia.Read moreRead less
Large Scale Production of Stemona Alkaloids for Agricultural Applications and New Drug Discovery. The Stemona alkaloids form a large group of natural products that have significant potential as agricultural and pharmaceutical drugs. Extracts of these natural products have many applications in traditional medicine and as insecticides in Asia. We propose to develop innovative methods for the large scale production and synthesis of these bioactive alkaloids. The methodology and products developed ....Large Scale Production of Stemona Alkaloids for Agricultural Applications and New Drug Discovery. The Stemona alkaloids form a large group of natural products that have significant potential as agricultural and pharmaceutical drugs. Extracts of these natural products have many applications in traditional medicine and as insecticides in Asia. We propose to develop innovative methods for the large scale production and synthesis of these bioactive alkaloids. The methodology and products developed may have potential pharmaceutical and agricultural applications from which the country could benefit in the future. This project would help develop skilled people who may produce innovative outcomes in the future, especially in the developing pharmaceutical and biotechnology industries in Australia.Read moreRead less
Fertility Management of Koalas, Kangaroos and Wallabies. The aims of this work are to test a commercially available long-acting contraceptive on large populations of kangaroos and koalas, and to devise efficient, economic and practical ways of delivering these contraceptives to the animals. The outcome will be a system of controlling the number of these animals which is economically realistic and acceptable to national and international communities. The contraceptive is administered as a small, ....Fertility Management of Koalas, Kangaroos and Wallabies. The aims of this work are to test a commercially available long-acting contraceptive on large populations of kangaroos and koalas, and to devise efficient, economic and practical ways of delivering these contraceptives to the animals. The outcome will be a system of controlling the number of these animals which is economically realistic and acceptable to national and international communities. The contraceptive is administered as a small, subcutaneous implant in the back of the neck. It can be inserted very quickly and has no harmful side effects. A further outcome may be its adoption in other parts of the world, to the advantage of the company which manufactures it.Read moreRead less
Integrated approach to functional carbon based materials. Exploiting novel forms of carbon to create new technologies for the energy, health and environmental sectors is a major challenge in nanotechnology. To address this challenge we will exploit innovative methods such as self-assembly and continuous flow spinning disc processing. Our proposed research will make significant contributions to a fundamental understanding of carbon nanomaterials. To this end, we will bring together international ....Integrated approach to functional carbon based materials. Exploiting novel forms of carbon to create new technologies for the energy, health and environmental sectors is a major challenge in nanotechnology. To address this challenge we will exploit innovative methods such as self-assembly and continuous flow spinning disc processing. Our proposed research will make significant contributions to a fundamental understanding of carbon nanomaterials. To this end, we will bring together international expertise with complementary skills, providing a more inventive research culture and excellent opportunities for training young scientists. The attractive low cost of renewable starting materials and small footprint of the ensuing technologies will provide a platform for fostering links with industry.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC190100034
Funder
Australian Research Council
Funding Amount
$3,574,272.00
Summary
ARC Training Centre for Green Chemistry in Manufacturing. Globally, there is demand for products that are effective, safe and environmentally benign. The ARC Training Centre for Green Chemistry in Manufacturing aims to utilise local and global experts to provide the next generation of Australian chemists and engineers, with skills to develop innovative products and processes that are intrinsically safe and benign. It will provide collaborating partners and the broader manufacturing industry with ....ARC Training Centre for Green Chemistry in Manufacturing. Globally, there is demand for products that are effective, safe and environmentally benign. The ARC Training Centre for Green Chemistry in Manufacturing aims to utilise local and global experts to provide the next generation of Australian chemists and engineers, with skills to develop innovative products and processes that are intrinsically safe and benign. It will provide collaborating partners and the broader manufacturing industry with new products and processes with strong export potential, and the ability to respond to the market pressures, underpinned by green chemistry and sustainable principles. Resulting benefits include increased competitiveness for Australia's manufacturing industry, jobs, social as well as environmental benefitsRead moreRead less
Optimisation of pigment coating surface treatments. Control and optimisation of surface coatings in pigment processing will lead to improved production efficiency and quality. In pigment processing, technology developed in this project may not only save millions of dollars in increased production efficiency but also lead to improved pigment optical performance in pigment applications such as paints, plastics and pharmaceuticals.
Recombinant probiotics for prevention of enteric infections in piglets. Shigatoxigenic and enterotoxigenic strains of Escherichia coli cause severe diarrhoeal disease and oedema disease in piglets. The resultant morbidity and mortality is a major cause of financial loss to the pig industry both in Australia and overseas. We have conceived a highly novel approach to prevention of these diseases involving molecular mimicry of host receptors for the E. coli toxins and adhesins on the surface of a ....Recombinant probiotics for prevention of enteric infections in piglets. Shigatoxigenic and enterotoxigenic strains of Escherichia coli cause severe diarrhoeal disease and oedema disease in piglets. The resultant morbidity and mortality is a major cause of financial loss to the pig industry both in Australia and overseas. We have conceived a highly novel approach to prevention of these diseases involving molecular mimicry of host receptors for the E. coli toxins and adhesins on the surface of a harmless bacterium. Oral administration of this agent to piglets has the potential to bind free toxins in the gut and prevent colonization of the intestines by the pathogens, thereby preventing disease.Read moreRead less
Biologically active peptides from Australian and Russian Amphibians. Bowie's group has identified many host-defence peptides from Australian anurans, including antimicrobial and anticancer active peptides, and neuropeptides that inhibit the formation of the ubiquitous chemical messenger nitric oxide. Lebedev's group from Moscow have initiated a collaboration with us to investigate active peptides from unstudied Russian frogs and newts. Preliminary investigations show these are very different f ....Biologically active peptides from Australian and Russian Amphibians. Bowie's group has identified many host-defence peptides from Australian anurans, including antimicrobial and anticancer active peptides, and neuropeptides that inhibit the formation of the ubiquitous chemical messenger nitric oxide. Lebedev's group from Moscow have initiated a collaboration with us to investigate active peptides from unstudied Russian frogs and newts. Preliminary investigations show these are very different from those isolated from Australian anurans and some already show potential for development as pharmaceuticals.Read moreRead less