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Advanced separators for lithium-sulphur batteries. This project aims to develop new membranes for use as separators in lithium-sulphur batteries. Currently diffusion of polysulphides within these batteries reduces battery power and lifetime. The new membranes are intended to block polysulphide diffusion over an extended lifetime, while transporting the other ions needed for the battery to function. The project is expected to generate new membrane materials and further knowledge about the design, ....Advanced separators for lithium-sulphur batteries. This project aims to develop new membranes for use as separators in lithium-sulphur batteries. Currently diffusion of polysulphides within these batteries reduces battery power and lifetime. The new membranes are intended to block polysulphide diffusion over an extended lifetime, while transporting the other ions needed for the battery to function. The project is expected to generate new membrane materials and further knowledge about the design, synthesis and larger-scale production of membranes for electrochemical applications. This project will provide significant benefits by producing potentially lighter, longer-lasting and cheaper batteries than existing lithium-ion technologies, with the potential to accelerate the adoption of electric cars.Read moreRead less
Nanoarchitectured multifunctional porous superparamagnetic nanoparticles. This project aims to develop a method for the direct detection of biomarkers based on a new class of highly porous superparamagnetic nanoparticles with peroxidase-like activity. The particles will be used as dispersible capture agents for isolating specific targets in biological samples, and electrocatalytic nanozymes for naked-eye evaluation and electrochemical detection. The project is expected to develop simple, low-cos ....Nanoarchitectured multifunctional porous superparamagnetic nanoparticles. This project aims to develop a method for the direct detection of biomarkers based on a new class of highly porous superparamagnetic nanoparticles with peroxidase-like activity. The particles will be used as dispersible capture agents for isolating specific targets in biological samples, and electrocatalytic nanozymes for naked-eye evaluation and electrochemical detection. The project is expected to develop simple, low-cost, portable devices for the analysis of exosomes and exosomal miRNA in biological samples. The future development of this technology into diagnostic devices will improve patient outcomes by enabling earlier disease diagnosis and improved monitoring of treatment.Read moreRead less
Engineering two dimensional polymers for membrane-based chemical separation. This project aims to develop novel two-dimensional polymers with precisely controlled pore-sizes for preparing membrane materials which can efficiently separate these gaseous chemicals at ambient temperatures. Key industrial chemical mixtures with similar size and boiling points are difficult to separate by conventional distillation methods. Currently, purification of olefins alone accounts for 0.3% of global energy use ....Engineering two dimensional polymers for membrane-based chemical separation. This project aims to develop novel two-dimensional polymers with precisely controlled pore-sizes for preparing membrane materials which can efficiently separate these gaseous chemicals at ambient temperatures. Key industrial chemical mixtures with similar size and boiling points are difficult to separate by conventional distillation methods. Currently, purification of olefins alone accounts for 0.3% of global energy use. The expected outcomes of the project will have a huge impact on industrial purification processing by providing a disruptive membrane technology, and will significantly reduce energy consumption and open up new routes for resources.Read moreRead less
Polymer nanodiscs. This project aims to produce disc-shaped polymer nanomaterials by utilising a new self-assembly concept based on oppositely charged polymers. This project expects to generate a modular technology that allows synthesis and control over the geometry and functionality of polymer nanoparticles. This level of control will permit a precise investigation of polymer nanodisc properties for nanomedicine applications. Expected outcomes of this project will be the fundamental understandi ....Polymer nanodiscs. This project aims to produce disc-shaped polymer nanomaterials by utilising a new self-assembly concept based on oppositely charged polymers. This project expects to generate a modular technology that allows synthesis and control over the geometry and functionality of polymer nanoparticles. This level of control will permit a precise investigation of polymer nanodisc properties for nanomedicine applications. Expected outcomes of this project will be the fundamental understanding of how nanoparticle geometry affects particle-cell interaction and how nanoscale polymer discs can be used to mimic biological nanoparticles in shape and function.Read moreRead less
Bespoke nanomaterials for understanding nano-bio interactions under flow. This project aims to develop innovative scalable synthesis techniques to produce polymeric nanomaterials with controlled properties and characterise interactions between nanomaterials and cells under flow conditions. This project expects to generate new knowledge in priority research areas of nanotechnology, polymer chemistry and immunology. The outcome of this project is an original scalable and environmentally friendly t ....Bespoke nanomaterials for understanding nano-bio interactions under flow. This project aims to develop innovative scalable synthesis techniques to produce polymeric nanomaterials with controlled properties and characterise interactions between nanomaterials and cells under flow conditions. This project expects to generate new knowledge in priority research areas of nanotechnology, polymer chemistry and immunology. The outcome of this project is an original scalable and environmentally friendly technology, new knowledge of cell-nanomaterial interactions and new design principles for nanoparticles with potential future applications in drug delivery, immunology and nanomedicine. This project should provide significant benefits to polymer, nanomaterial and pharmaceutical research and industry in Australia.Read moreRead less
Next-generation lithography: photo-directing assembly of block copolymers. This project aims to introduce a novel approach to organising block polymers through the photochemical modification of the surface of a photo-sensitive polymer. Chemo-epitaxy is the science of organising materials on a surface decorated with chemical patterns. The process has the potential to revolutionise the manufacture of integrated circuits, enabling faster processors. This project expects to introduce innovative conc ....Next-generation lithography: photo-directing assembly of block copolymers. This project aims to introduce a novel approach to organising block polymers through the photochemical modification of the surface of a photo-sensitive polymer. Chemo-epitaxy is the science of organising materials on a surface decorated with chemical patterns. The process has the potential to revolutionise the manufacture of integrated circuits, enabling faster processors. This project expects to introduce innovative concepts in polymer chemistry and nanoscale assembly with the potential to advance a multi-billion-dollar industry.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230101044
Funder
Australian Research Council
Funding Amount
$444,318.00
Summary
Bio-inspired nanomaterials with tunable drug loading and controlled release. This project aims to develop new platform technologies for making bio-inspired nanomaterials with tunable drug loading and controlled release. This project will revolutionise current approaches to make lipid nanoparticles camouflaged with natural cell membranes for delivery of both insoluble and soluble drugs. Significant outcomes will include a novel commercially relevant salt-induced nanoprecipitation platform technol ....Bio-inspired nanomaterials with tunable drug loading and controlled release. This project aims to develop new platform technologies for making bio-inspired nanomaterials with tunable drug loading and controlled release. This project will revolutionise current approaches to make lipid nanoparticles camouflaged with natural cell membranes for delivery of both insoluble and soluble drugs. Significant outcomes will include a novel commercially relevant salt-induced nanoprecipitation platform technology for making precisely engineered nanomaterials with tailored functions for applications in controlled release and targeted delivery. Benefits include securing a sustainable future for Australia, with new nanotechnology strategies for advanced manufacturing.Read moreRead less
Bio-inspired Nanoparticles for Mechano-Regulation of Stem Cell Fate. Mechanical stimulation plays a critical role in regulating stem cell fate. Nanostructure-mediated mechanical cues can precisely stimulate stem cells, but predicting their impact on stem cell differentiation is challenging. This project aims to engineer nanostructures to regulate stem cell fate and gain a fundamental understanding of the mechanical properties that affect cell function. The expected outcomes and benefits of this ....Bio-inspired Nanoparticles for Mechano-Regulation of Stem Cell Fate. Mechanical stimulation plays a critical role in regulating stem cell fate. Nanostructure-mediated mechanical cues can precisely stimulate stem cells, but predicting their impact on stem cell differentiation is challenging. This project aims to engineer nanostructures to regulate stem cell fate and gain a fundamental understanding of the mechanical properties that affect cell function. The expected outcomes and benefits of this project include a new fundamental understanding of the effect of mechanical properties on cell function, novel insights into the regulation of stem cell fate, and the development of a new class of roughness-tunable materials suitable for use in tissue engineering and pharmaceutical applications. Read moreRead less
Precision-engineered hybrid core-shell materials . This project aims to develop new platform technologies for making nanostructured hybrid core-shell materials with exceptionally high drug loading and programmed release. Building on this research team's recent breakthrough in the precision engineering of core-shell materials, this research will revolutionise current approaches for making drug-loaded polymer and inorganic particles. Significant outcomes will include a novel sequential nanoprecipi ....Precision-engineered hybrid core-shell materials . This project aims to develop new platform technologies for making nanostructured hybrid core-shell materials with exceptionally high drug loading and programmed release. Building on this research team's recent breakthrough in the precision engineering of core-shell materials, this research will revolutionise current approaches for making drug-loaded polymer and inorganic particles. Significant outcomes will include a novel sequential nanoprecipitation platform technology for making drug-core polymer-shell nanoparticles, and a new bio-inspired approach for making hybrid drug-core silica-shell nanocomposites, and new materials for applications in programmed release and delivery systems.Read moreRead less
Advanced electrocatalysts for ammonia synthesis with validated analysis. Ammonia is one of the most produced chemicals worldwide but current manufacturing industries consume massive amounts of energy and emit harmful greenhouse gases. This project aims to develop a sustainable electrochemical system for ammonia synthesis using electricity and atmospheric nitrogen. A family of porous catalysts with nanoconfined ionic liquids will be developed to drive nitrogen reduction by enhancing the reaction ....Advanced electrocatalysts for ammonia synthesis with validated analysis. Ammonia is one of the most produced chemicals worldwide but current manufacturing industries consume massive amounts of energy and emit harmful greenhouse gases. This project aims to develop a sustainable electrochemical system for ammonia synthesis using electricity and atmospheric nitrogen. A family of porous catalysts with nanoconfined ionic liquids will be developed to drive nitrogen reduction by enhancing the reaction kinetics. Rigorous experimental protocols and novel analytical methods will be developed for quantification of electro-synthesised ammonia. A prototype gas diffusion layer-assisted electrolyser will be demonstrated by coupling with oxygen evolution reactions for selective ammonia synthesis at a reasonable production rate.Read moreRead less