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Australian Laureate Fellowships - Grant ID: FL150100060
Funder
Australian Research Council
Funding Amount
$2,875,097.00
Summary
The first generation of single entity measurement tools for analysis. The first generation of single entity measurement tools for analysis: This fellowship project aims to develop a new type of diagnostic device that measures single molecules or single cells. Such measurements seek to revolutionise analysis by allowing heterogeneity and rare events in samples to be identified, rather than the average information provided by existing tools. With single molecule devices, the heterogeneity in respo ....The first generation of single entity measurement tools for analysis. The first generation of single entity measurement tools for analysis: This fellowship project aims to develop a new type of diagnostic device that measures single molecules or single cells. Such measurements seek to revolutionise analysis by allowing heterogeneity and rare events in samples to be identified, rather than the average information provided by existing tools. With single molecule devices, the heterogeneity in response enables the development of multiplexed, calibration free sensors. The outcomes of the project are hoped to be completely new thinking on performing measurements, new knowledge regarding heterogeneity in biology and the potential for novel commercialised sensors. It is expected that this will be important not only in biological discovery, but also in providing far more robust sensors for applications such as environmental monitoring, disease prediction, personalised medicine or drug discovery.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL120100030
Funder
Australian Research Council
Funding Amount
$2,779,572.00
Summary
Engineering materials for advances in nanomedicine. Nanomedicine is one of the fastest growing areas in nanotechnology. This project will develop next-generation particle systems with engineered properties that are expected to underpin advances in the delivery of therapeutics in the areas of cancer, vaccines, cardiovascular disease and neural health.
Australian Laureate Fellowships - Grant ID: FL140100081
Funder
Australian Research Council
Funding Amount
$2,380,000.00
Summary
Engineering hybrid photocatalytic systems for sustainable fuel generation. Engineering hybrid photocatalytic systems for sustainable fuel generation. The project aims to develop next generation hybrid photo-(co)catalyst and gaseous photoelectrode systems that will effectively harness solar energy to transform carbon dioxide into sustainable fuels using a multi-scale approach: designing hetero-structured material systems; elucidating surface reaction mechanisms, and engineering coupled photo/ther ....Engineering hybrid photocatalytic systems for sustainable fuel generation. Engineering hybrid photocatalytic systems for sustainable fuel generation. The project aims to develop next generation hybrid photo-(co)catalyst and gaseous photoelectrode systems that will effectively harness solar energy to transform carbon dioxide into sustainable fuels using a multi-scale approach: designing hetero-structured material systems; elucidating surface reaction mechanisms, and engineering coupled photo/thermal-catalytic and unique gaseous photoelectrochemical systems. This project aims to yield fundamental new knowledge for the economical conversion and storage of solar energy as an environmentally benign chemical fuel, as well as create contemporary material systems and reactors for photo- and thermal-catalysis and photoelectrochemical reactions that utilise carbon dioxide as a feedstock.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL120100017
Funder
Australian Research Council
Funding Amount
$3,215,016.00
Summary
Turbulence: physical modelling and application to aquatic ecosystem functions. Turbulent fluid motions in aquatic systems are critical for many aspects of water health. This project will quantify the effects of these motions in an unprecedented way by addressing the long-standing problem of turbulence, and the outcomes will be applicable to the essential task of strengthening Australia’s water security.
Australian Laureate Fellowships - Grant ID: FL150100146
Funder
Australian Research Council
Funding Amount
$2,977,310.00
Summary
Taking Australia from the farm to the pharm. Taking Australian from the farm to the pharm: This fellowship project aims to design novel drugs based on cyclic peptides that will be expressed in the seeds of plants to produce bio-pills — saving money for patients and the health care system. Plants produce unique cyclic peptides (mini-proteins) to protect themselves from pests and pathogens. This project aims to chemically redesign these peptides to produce stable protein-based pharmaceuticals that ....Taking Australia from the farm to the pharm. Taking Australian from the farm to the pharm: This fellowship project aims to design novel drugs based on cyclic peptides that will be expressed in the seeds of plants to produce bio-pills — saving money for patients and the health care system. Plants produce unique cyclic peptides (mini-proteins) to protect themselves from pests and pathogens. This project aims to chemically redesign these peptides to produce stable protein-based pharmaceuticals that can be eaten. It is hoped that these designer pharmaceuticals will be inexpensive, effective, easy to ingest and without the side effects of traditional drugs. The outcomes of this project are anticipated to be high-value drugs and agri-chemicals which will open up new high-value crops for Australian farmers and a new Australian ‘pharming’ industry.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL140100052
Funder
Australian Research Council
Funding Amount
$2,500,000.00
Summary
Macromolecular design for bio-imaging and targeted delivery. Macromolecular design for bio-imaging and targeted delivery. A thorough understanding of how nanoparticles interact with biological systems is imperative if advances are to be made in using nanotechnology for therapeutic applications. Fundamental aspects of nanoparticle transport, targeting and cell uptake will be investigated. This project aims to design novel nanoparticulate systems for the delivery of both an endogenous signalling ....Macromolecular design for bio-imaging and targeted delivery. Macromolecular design for bio-imaging and targeted delivery. A thorough understanding of how nanoparticles interact with biological systems is imperative if advances are to be made in using nanotechnology for therapeutic applications. Fundamental aspects of nanoparticle transport, targeting and cell uptake will be investigated. This project aims to design novel nanoparticulate systems for the delivery of both an endogenous signalling molecule and genes to cells. The project aims to inform future optimal design criteria for bespoke nanoparticle delivery systems.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL170100041
Funder
Australian Research Council
Funding Amount
$2,327,500.00
Summary
Controlling chemical reactions via pH-switchable electrostatic catalysis. This project aims to establish a new approach to catalysis using the electrostatic effects of pH-switchable, charged functional groups. Utilising simple homogeneous catalysts and polymer-supported enzyme-mimicking catalysts, a wide range of target reactions will be studied. The expected outcomes of the project will include a new approach to the design and optimisation of several new classes of catalyst for assembling compl ....Controlling chemical reactions via pH-switchable electrostatic catalysis. This project aims to establish a new approach to catalysis using the electrostatic effects of pH-switchable, charged functional groups. Utilising simple homogeneous catalysts and polymer-supported enzyme-mimicking catalysts, a wide range of target reactions will be studied. The expected outcomes of the project will include a new approach to the design and optimisation of several new classes of catalyst for assembling complex molecules and materials. The project also offers a unique opportunity to train the next generation of chemists in the principles of computer-aided chemical design. The catalysts developed in this project will be able to accelerate and control the chemical reactions used in the synthesis of pharmaceuticals and materials, with significant practical benefits to industry.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL120100049
Funder
Australian Research Council
Funding Amount
$3,229,566.00
Summary
A new paradigm for quantifying the resilience of marine calcifiers to ocean acidification and global warming. This multi-disciplinary research project will determine the future of coral reefs and marine calcifiers in response to rising carbon dioxide and ocean acidification. This will enable best-practice adaptive management at local and regional-scales for marine-dependent industries, and provide new hope for some of our greatest natural assets, coral reefs.
Australian Laureate Fellowships - Grant ID: FL100100117
Funder
Australian Research Council
Funding Amount
$2,713,582.00
Summary
Molecular Plasmonics - From Single Electrons to Quantum Catalysis and Optical Logic Gates. After a decade of basic research, Nanotechnology is now entering its most disruptive phase. New nanoscale phenomena are being exploited and converted into viable technologies. Plasmonics - the manipulation of light using metal nanostructures - is one of the most promising of these. Plasmonics will enable scientists to achieve optical computing, reach higher data storage densities, and synthesize better cat ....Molecular Plasmonics - From Single Electrons to Quantum Catalysis and Optical Logic Gates. After a decade of basic research, Nanotechnology is now entering its most disruptive phase. New nanoscale phenomena are being exploited and converted into viable technologies. Plasmonics - the manipulation of light using metal nanostructures - is one of the most promising of these. Plasmonics will enable scientists to achieve optical computing, reach higher data storage densities, and synthesize better catalysts. Other applications include bio-sensing and rapid pathogen detection. To realise these potential outcomes, a leading international cluster focussing on plasmonics will be set up and this cluster will link state-of-the-art materials science, instrumentation and theory.Read moreRead less