Impact Of Co-morbidities On Screening, Diagnosis, Treatment And Survival Of Cervical Cancer Amongst Australian Indigenous And Non-Indigenous Women: 1997-2009
Funder
National Health and Medical Research Council
Funding Amount
$98,236.00
Summary
Indigenous women are more likely than non-Indigenous Australian women to be diagnosed with cervical cancer and are less likely to survive it. This study will investigate the impact of co-exisiting chronic diseases (co-morbidities) on cervical cancer screening, diagnosis, treatment and survival outcomes for Indigenous compared to non-Indigenous women. Results from this study will assist in directing future public health initiatives that aim to improve outcomes for women with cervical cancer.
Pre-eclampsia is a serious medical condition affecting 5% of pregnancies and resulting in significant mortality and morbidity for mothers and babies. As yet there is no acceptable test capable of detecting pre-eclampsia in early pregnancy and diagnosis is made when symptoms and signs are manifest and management options are limited to early delivery. This project is designed to assess the ability of a blood screening test to detect pre-eclampsia in early pregnancy to enable for early intervention ....Pre-eclampsia is a serious medical condition affecting 5% of pregnancies and resulting in significant mortality and morbidity for mothers and babies. As yet there is no acceptable test capable of detecting pre-eclampsia in early pregnancy and diagnosis is made when symptoms and signs are manifest and management options are limited to early delivery. This project is designed to assess the ability of a blood screening test to detect pre-eclampsia in early pregnancy to enable for early interventions and preventative management to be implemented.Read moreRead less
A Glint Or A Squint Should Make You Think! A Randomised, Controlled Study To Determine The Impact Of An Eye-health Awareness Program For New Parents
Funder
National Health and Medical Research Council
Funding Amount
$95,348.00
Summary
Retinoblastoma (RB) is a rare, blinding and sometimes fatal, childhood eye cancer. The earliest diagnosis affords the child the best prognosis for retaining their sight, eye or their life. This project will examine parents’ current understanding of the symptoms and signs for RB, identify barriers to early diagnosis of RB, and to develop, implement and evaluate a sustainable public health awareness program to potentially improve the timing of diagnosis and subsequent outcomes for this disease.
The Indigenous Australian Malnutrition project aims to explore the burden and impact of malnutrition particularly for Aboriginal and Torres Strait Islander patients in hospital. The project includes the development and validation of the Australian Nutrition Tool (ANT) and validating the Malnutrition Screening Tool (MST) as an appropriate screening tool for Indigenous Australian patients. The project also aims to determine the prevalence of adult malnutrition and explore its burden and impact.
Automated Screening Measures Associated With Risk And Treatment (SMART) Of Breast Cancer
Funder
National Health and Medical Research Council
Funding Amount
$98,244.00
Summary
Women with greater mammographic density (white area on a mammogram) are at greater risk of breast cancer. Prof Hopper (supervisor) has led international research in this area using a method called CUMULUS. Drs Makalic and Schmidt (co-supervisors) have created an automated measure, called CIRRUS. My aims are to: find out which factors influence CIRRUS, confirm that CIRRUS predicts breast cancer risk, and develop automated measures of a breast cancer risk based on magnetic resonance imaging (MRI).
Gestational diabetes is an important medical condition. We plan to investigate two subgroups of women with gestational diabetes. Firstly, women who have diabetes antibodies in pregnancy. Secondly, women who have a mild form of diabetes caused by a single gene mutation, who may be first identified during pregnancy. Correct identification of these subgroups of women is important for immediate and long-term management of both the mother and her fetus.
Novel Inhibition Of Cancer Cell Growth In Gastrointestinal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$47,474.00
Summary
This research project will focus on new treatment targets for gastrointestinal malignancies, focusing on the mTOR pathway which is important in driving cancer cell growth. The mTOR inhibitor drug Everolimus will be used in colon and biliary tract cancers to look for novel biomarkers of response and resistance to treatment, using cancer cell lines and correlative analysis with data obtained from patients' tumour samples and clinical assessment in current trials.
Quantifying Breast Cancer Over-diagnosis In An Organized Mammography Screening Program
Funder
National Health and Medical Research Council
Funding Amount
$92,314.00
Summary
While breast screening reduces breast cancer deaths by finding cancers earlier, it may also find cancers that would never have required treatment. Currently there is no clear consensus about the level over-diagnosis. This study will examine the extent of over-diagnosis by comparing the breast screening histories of women diagnosed with breast cancer and women who have not had breast cancer. Findings will inform policy on breast screening in Australia.
Anal Cancer Examination (ACE) Study - Annual Anal Examinations To Detect Early Anal Cancer In HIV Positive Men Who Have Sex With Men
Funder
National Health and Medical Research Council
Funding Amount
$60,926.00
Summary
Anal cancer is the most frequently occurring (non-AIDS defining) cancer in HIV positive men who have sex with men. There are still no guidelines for how to screen for this cancer. This research aims to determine the feasibility of implementing an annual anal examination to detect early anal cancer in HIV positive men who have sex with men.
I am a paediatrician with experience in tropical medicine in northern Australia, the Solomon Islands and Fiji. The prevalence of Rheumatic Heart Disease in the Pacific, including Indigenous children in Australia, is amongst the highest in the world, and my project will investigate ways to reduce the burden of this disease. I will examine population screening with echocardiography (ultrasound) to detect the disease before children become sick, and investigate ways to improve patient management.