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The major objective of this research is to advance the development of highly effective malaria vaccines through i) defining mechanisms and targets of human immunity to malaria to establish a rational basis for vaccine design; ii) advancing the development of lead candidates and promising new candidates and combinations; iii) advancing vaccine platforms that induce potent protective immune responses; iv) develop and validate urgently-needed immunological assays for vaccine development and testing
Dr. Ivo Mueller is global leader in the study of non-African malaria with a special focus on the SW Pacific and on P. vivax. His research at the Walter & Eliza Hall Institute focuses on population-based studies of host-vector-parasite interactions and their effect on burden and transmission of different malaria parasites as well as improving treatment & prevention of malaria in children and pregnant mothers and thereby contributing to the development of new tools to control and eliminate malaria
I am a public health physician and medical parasitologist determining the mechanism of clinical immunity to malaria, and working on the development of vaccines and therapies against malaria.
We will investigate malaria, a parasitic disease that kills over 600,000 people a year. We will explore how the parasite identifies, invades and remodels the host cells in which it lives, scavenging nutrients and hiding from the immune system. We will characterize the proteins involved in these critical events, as they are potential targets for drugs and vaccines. We will study how parasites cause disease and how the host responds to infection.
Implementing Neuroprotective Strategies For Fetal Growth Restriction
Funder
National Health and Medical Research Council
Funding Amount
$782,370.00
Summary
Fetal growth restriction (FGR) is a serious and common complication of pregnancy that is a principal cause of injury to the developing fetal brain. In turn, damage to the developing brain during pregnancy may cause cerebral palsy and other cognitive and behavioural deficits. This proposal builds on my work to date characterising the mechanisms that contribute to neuropathology in FGR infants, by implementing targeted strategies to protect or repair the FGR brain.
Immunology And Pathogenesis Of Malaria: Basic And Translational Research
Funder
National Health and Medical Research Council
Funding Amount
$727,685.00
Summary
Malaria is one of the most serious infectious diseases of humanity, killing 1-2 million children annually. In order to develop effective vaccines and interventions, it is important to understand both the causes of fatality and how to develop immunity to the disease. This application will continue a very strong international track record in malaria research ranging from basic lab-based molecular studies through to commercial development and population based health studies and policy formulation.
Stroke is a devastating disease causing mortality and morbidity on a massive scale, and which still has no treatment besides a clot-buster that cannot be used in 90% of patients. This research should provide a better understanding of stroke pathology and identify new therapeutic directions. It will elucidate an unappreciated but crucial role of specific immune cells in brain injury after stroke, and hopefully lead to new ways to limit brain injury and promote recovery from stroke.
This an integrated program of basic research on antigen discovery and immune mechanisms, and preclinical research on novel vaccine platforms, formulations or delivery systems for the rational design and clinical testing of a next generation vaccine against malaria. This interdisciplinary research fosters strong national and international links and offers the potential for significant economic benefit to Australia.
Cerebral Palsy is most common childhood physical disability. While the brain injury is static, disability can be progressive and lifelong. This fellowship aims to develop and test novel interventions to optimise neuroplasticity by improving early detection and physical, cognitive, psychological and health outcomes in children with CP. Earlier accurate detection of CP will ensure effective treatments utilise critical periods of brain development and are translated into evidence based guidelines.
We will investigate malaria, a parasitic disease that kills over 2 million people a year. We will explore how the parasite identifies, invades and remodels the host cells in which it lives, scavenging nutrients and hiding from the immune system. We will characterize the proteins involved in these critical events, as they are potential targets for drugs and vaccines. We will study how parasites cause disease and how the host responds to infection.