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Blood-Spinal Cord Barrier Structure And Function In Syringomyelia
Funder
National Health and Medical Research Council
Funding Amount
$82,630.00
Summary
Syringomyelia is a disorder in which a fluid-filled cyst forms within the spinal cord. These cysts expand over time resulting in paralysis or even death. Syringomyelia occurs in association with spinal cord injury and a number of congenital conditions. In this project we aim to investigate the underlying cause of cyst formation, which is currently unknown. It is hoped that these studies will improve our understanding of cyst formation and facilitate development of better treatment strategies.
The Role Of Central Neural Pathways In The Determination Of Body Fat Mass
Funder
National Health and Medical Research Council
Funding Amount
$73,361.00
Summary
Obesity and its associated health risks are a developing world problem. Fat is not distributed uniformly in an individual; females have more subcutaneous, and males more abdominal, fat. Abdominal fat is associated with the health risks of obesity. The aims of the current project are to examine the neuronal pathways from the brain to fat and the chemicals involved in order to better understand the way in which fat distribution is determined in the body and develop appropriate therapies.
Effects Of Hypothalamus-specific NPY Y1 And Y5 Receptor Deletion In High Fat Diet-induced Obesity
Funder
National Health and Medical Research Council
Funding Amount
$60,420.00
Summary
Obesity is a rising global epidemic, contributing to severe morbidity and mortality and extreme financial burden on society. It is known that the brain controls energy metabolism via molecules such as neuropeptide Y, which has two key receptors involved in weight gain, Y1 and Y5. This study looks at deleting Y1 and Y5 in the brain of overfed subjects to demonstrate their involvement in metabolic adaptations that prevent weight gain in overfeeding, thus developing effective weight loss therapies ....Obesity is a rising global epidemic, contributing to severe morbidity and mortality and extreme financial burden on society. It is known that the brain controls energy metabolism via molecules such as neuropeptide Y, which has two key receptors involved in weight gain, Y1 and Y5. This study looks at deleting Y1 and Y5 in the brain of overfed subjects to demonstrate their involvement in metabolic adaptations that prevent weight gain in overfeeding, thus developing effective weight loss therapies to treat obesity.Read moreRead less