Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS rese ....Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS research including epidemiology, immunology and neurobiology. Collaboration of 8 major Australian institutions is also important for this project and future studies. The team will have access to a new national MS GeneBank (platform) with samples from 2240 patients that should generate findings important to world-wide MS genetic knowledge.Read moreRead less
How do myelinating cells alter brain circuits to facilitate learning? This project aims to identify the brain circuits that receive new insulation and characterise the molecular mediators of this process. This project will apply innovative technologies to understand how the nervous system remains adaptable throughout life. This new knowledge, of the cellular mechanisms that allow brain circuits to remain adaptable throughout life, may have application in the development of interventions aimed at ....How do myelinating cells alter brain circuits to facilitate learning? This project aims to identify the brain circuits that receive new insulation and characterise the molecular mediators of this process. This project will apply innovative technologies to understand how the nervous system remains adaptable throughout life. This new knowledge, of the cellular mechanisms that allow brain circuits to remain adaptable throughout life, may have application in the development of interventions aimed at improving educational outcomes or counteracting age-related memory decline. Potential future benefits include facilitating the development of drugs to circumvent memory loss resulting from brain diseases, and improving the design of neuromorphic hardware for computing.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989788
Funder
Australian Research Council
Funding Amount
$108,481.00
Summary
Nuclear Magnetic Resonance Microimaging and Relaxometry Facility. Many of the research projects to be supported by the facility are dedicated to improving our understanding of conditions and diseases that detrimentally affect many in our community. Projects investigating Alzheimer's disease, the central nervous system and its ability to repair, cancer and associated therapeutic treatments are some of the areas that will benefit from access to this equipment. The new facility will also provide un ....Nuclear Magnetic Resonance Microimaging and Relaxometry Facility. Many of the research projects to be supported by the facility are dedicated to improving our understanding of conditions and diseases that detrimentally affect many in our community. Projects investigating Alzheimer's disease, the central nervous system and its ability to repair, cancer and associated therapeutic treatments are some of the areas that will benefit from access to this equipment. The new facility will also provide unique insights into aspects of fundamental plant biology, with implications for improving crop productivity and better managing our natural ecosystems. The community will also benefit from the development and testing within the facility of new diagnostic tools and markers for a range of diseases.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100319
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
Fast three-dimensional imaging of neural signal propagation using light-field microscopy. This project aims to use a light-field microscope to reveal the dynamics of sustained neural activity in the brain. The brain’s neurons are highly interconnected, so neural signals can be sustained in a repeating cycle. While this may underlie tasks such as working memory, its role in information processing is unclear. Understanding information processing is vital for finding treatments for neurodegenerativ ....Fast three-dimensional imaging of neural signal propagation using light-field microscopy. This project aims to use a light-field microscope to reveal the dynamics of sustained neural activity in the brain. The brain’s neurons are highly interconnected, so neural signals can be sustained in a repeating cycle. While this may underlie tasks such as working memory, its role in information processing is unclear. Understanding information processing is vital for finding treatments for neurodegenerative disorders. To characterise this large-scale aspect of neural computation, this project measures neural activity at high speed across large numbers of neurons. This is expected to provide evidence of the nature of sustained activity which may in the future lead to treatments for neurodegenerative disorders.Read moreRead less
What is normal brain ageing? An investigation of changes in brain structure and cognition in mid-life. Pathological brain changes associated with cognitive decline later in life become detectable in the 40s and sometimes earlier, yet little is known about what constitute normal brain ageing in midlife. Using a number of neuroimaging techniques, this project will develop a detailed map of brain and cognitive ageing in middle-age and their predictors.
White Spot Syndrome Virus (WSSV) Preparedness For Biosecurity Awareness And Adoption Of Best Practice By The NSW And QLD Wild Catch Commercial Fishers - Understanding What Extension Pathways Work Best
Funder
Fisheries Research and Development Corporation
Funding Amount
$84,000.00
Summary
Objectives: 1. Develop appropriate extension material to reduce the risk of spread of WSSV from the control zone to the non control zones in QLD and NSW. 2. To quantify best extension practice for biosecurity for the commercial wild catch fishers. 3. To, where possible, utilise existing extension material developed by Biosecurity Queensland for the commercial wild catch fishery.
Field Observations And Assessment Of The Response To An Outbreak Of White Spot Disease (WSD) In Black Tiger Prawns (Penaeus Monodon) Farmed On The Logan River In November 2016
Funder
Fisheries Research and Development Corporation
Funding Amount
$52,663.15
Summary
Objectives: 1. Undertake assessment on the causative factors for the outbreak of WSD in the prawn farms in the Logan River region 2. Provide technical advice to APFA, QSIA, ACPF, Sunfish, ARFF and FRDC on the technical information arising from the eradication program for WSD 3. Undertake research and sampling for later assessment on how to improve the management of WSD and its erradication
The Prevention Of Occupationally-related Infections In Western Rock Lobster Fishermen
Funder
Fisheries Research and Development Corporation
Funding Amount
$158,901.00
Summary
The incidence and severity of infection associated with WRL does not appear to have changed vastly since 1949, despite penicillin therapy and a heightened awareness of the infection by those in the industry. Infection may result in loss of working days. Severe cases may progess to more serious conditions such as septic arthritis and endocarditis, potentially life-threatening conditions. The inappropriate and unnecessary use of antibiotics is of great concern currently as antibiotic resistant ba ....The incidence and severity of infection associated with WRL does not appear to have changed vastly since 1949, despite penicillin therapy and a heightened awareness of the infection by those in the industry. Infection may result in loss of working days. Severe cases may progess to more serious conditions such as septic arthritis and endocarditis, potentially life-threatening conditions. The inappropriate and unnecessary use of antibiotics is of great concern currently as antibiotic resistant bacteria emerge world-wide. The emphasis is now on preventing infection rather than treating it with antibiotics when it does occur. More advanced techniques for the recovery and detection of E. rhusiopathiae have been developed, including the use of selective media and a molecular method. Further study of these infections, utilising more appropriate techniques, is warranted to determine the exact role that E. rhusiopathiae has in this infection. Also, the role of other organisms causing apparent infection in fishermen of all types needs to be evaluated. This will allow preventive strategies to be developed which will, in turn, result in less infection and reduced exposure to antibiotics. Objectives: 1. To determine the role that E.rhusiopathiae plays in "crayfish poisoning". 2. To determine the distribution of E.rhusiopathiae in the work environment 3. To develop interventions and strategies to reduce the incidence of "crayfish poisoning" Read moreRead less
Oyster Depuration: A Re-assessment Of Depuration Conditions And The Role Of Bacterial And Viral Indicators In Determining Depuration Effectiveness
Funder
Fisheries Research and Development Corporation
Funding Amount
$284,053.03
Summary
The NSW oyster industry has suffered severe economic losses during the past 20 years as the result of major outbreaks of gastroenteritis and other oyster-borne diseases. Further outbreaks will cripple the industry from immediate losses and resulting litigation.
There is an urgent need to re-examine the conditions for depuration of NSW oysters harvested in very different geographic and environmental conditions with particular reference to water temperature, salinity and turbidity during ....The NSW oyster industry has suffered severe economic losses during the past 20 years as the result of major outbreaks of gastroenteritis and other oyster-borne diseases. Further outbreaks will cripple the industry from immediate losses and resulting litigation.
There is an urgent need to re-examine the conditions for depuration of NSW oysters harvested in very different geographic and environmental conditions with particular reference to water temperature, salinity and turbidity during depuration. It is important to determine what limitations exist in the current technology and how they might affect purification efficiency and commercial acceptance by oyster farmers. In light of such information, there will be a need to modify the Code of Practice for Oyster Depuration. Equally important is the need to educate and train oyster farmers in proper quality assurance of oyster quality and safety, which will include optimal application of purification technology.
Current safety of oysters is assessed by the presence of E. coli as indicators of bacterial pathogens, yet the majority of oyster-borne disease is of viral origin, principally NV and more recently, HAV. Unfortunately, direct testing for human viruses in oysters is time consuming and very expensive, and will remain so for the foreseeable future. From the perspective of implementing a quality assurance program that will effectively protect public health, it is essential to have more accurate and more reliable indicator tests for the presence of human viruses in oysters. Consequently, there is a clear need to examine the relationship between the presence of bacterial indicators (E. coli), coliphages and human infectious viruses in oysters before, during and after purification. Such a study will not only clarify the behaviour of viruses during purification but could lead to a rapid coliphage assay as a more accurate indicator of human virus presence in oysters. Objectives: 1. To optimize the process of oyster depuration with respect to conditions of: initial load of contamination; water temperature, salinity, turbidity and oxygen content; oyster: water ratio; time of depuration; geographical location of oysters; and oyster eating quality. 2. Based on the findings from objective 1, and in consultation with the NSW Department of Health, NSW Fisheries and representatives of the oyster industry, develop and write modifications to the Code of Practice for the Depuration of Oysters in NSW. 3. In conjunction with the NSW Shellfish Quality Assurance Program, conduct a series of workshops aimed at education of farmers in management of the quality and safety of oysters. 4. Investigate the possibility of using bacteriophages as an additional indicator of oyster safety and the performance of oyster depuration, with specific reference to the elimination of human viruses such as Norwalk and Hepatitis A viruses. Correlate bacteriophage occurrence and behaviour in oysters during purification with traditional E. coli standards and human virus behaviour as measured by an inactivated strain of polio virus. Read moreRead less