Platform technology to decode motor control through ultra high-field MRI. This project aims to advance our understanding of the poorly understood neural circuits that enable fine motor control in humans. To obtain this knowledge, new platform technology will be developed to capture the full kinematics of the hand during concurrent functional magnetic resonance imaging at ultra high-field. This device will allow testing of fundamental theories describing the canonical microcircuits involved in ha ....Platform technology to decode motor control through ultra high-field MRI. This project aims to advance our understanding of the poorly understood neural circuits that enable fine motor control in humans. To obtain this knowledge, new platform technology will be developed to capture the full kinematics of the hand during concurrent functional magnetic resonance imaging at ultra high-field. This device will allow testing of fundamental theories describing the canonical microcircuits involved in hand motion. Expected outcomes include new evidence of mirror neurons and observation of predictive error signals in the motor cortex. This new knowledge paves the way towards improved computer-brain interface technology which is likely to create benefits through translation to applications such as artificial limb control.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200101272
Funder
Australian Research Council
Funding Amount
$420,885.00
Summary
Glial Plasticity: How experience and aging change brain structure. 50 % of the cells in the brain are called glia. These cells work with neurons to regulate how we think, feel and behave. Most glial cells are added to the brain after birth, however we know very little about how this process works, or how it may be changed by lived-experience. The overarching aim of this study is to better understand how lived-experience impacts the growth of the major types of glial cells in the brain. To do th ....Glial Plasticity: How experience and aging change brain structure. 50 % of the cells in the brain are called glia. These cells work with neurons to regulate how we think, feel and behave. Most glial cells are added to the brain after birth, however we know very little about how this process works, or how it may be changed by lived-experience. The overarching aim of this study is to better understand how lived-experience impacts the growth of the major types of glial cells in the brain. To do this, I will use cutting-edge technologies and identify; 1) the rates of cell growth for the major types of glia, and 2) map how they are integrated into the brain. This will lead to important new information on how lived-experience can shape the growth and structure of the brain.Read moreRead less
Phenotyping doublecortin+ cells to unravel human adult neurogenesis. This project investigates one of the brain’s most remarkable phenomena: adult neurogenesis, the birth of new brain cells in a specialised brain area (the hippocampus) occurring well into adulthood. This process contributes to many species’ capacity to learn, remember and regenerate. However whether this process occurs in humans is heavily debated. Using new neuroscience tools, this project will produce new insights into human a ....Phenotyping doublecortin+ cells to unravel human adult neurogenesis. This project investigates one of the brain’s most remarkable phenomena: adult neurogenesis, the birth of new brain cells in a specialised brain area (the hippocampus) occurring well into adulthood. This process contributes to many species’ capacity to learn, remember and regenerate. However whether this process occurs in humans is heavily debated. Using new neuroscience tools, this project will produce new insights into human adult neurogenesis by deeply examining hippocampal cells that express the newborn cell marker, doublecortin. This will enable clarification of the existence and extent of adult neurogenesis in humans, and provide the foundation to leverage this process for improving learning, memory and brain regeneration in people.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100269
Funder
Australian Research Council
Funding Amount
$422,232.00
Summary
Mapping the neural circuits which control water and salt intake. This project aims to map the brain circuits controlling fluid and salt intake using innovative genetically encoded techniques, which enable precise targeting and manipulation of select neuronal populations. Expected outcomes of this project include constructing detailed maps of the brain circuits for fluid and salt intake by tracing multiple nodes in the network, characterising neuronal populations, and precisely defining their fun ....Mapping the neural circuits which control water and salt intake. This project aims to map the brain circuits controlling fluid and salt intake using innovative genetically encoded techniques, which enable precise targeting and manipulation of select neuronal populations. Expected outcomes of this project include constructing detailed maps of the brain circuits for fluid and salt intake by tracing multiple nodes in the network, characterising neuronal populations, and precisely defining their functions. This should provide significant benefits including understanding the brain regions controlling fluid and salt intake which are essential for maintaining fluid homeostasis, and providing a framework for investigating the neural circuits underlying other complex behaviours.Read moreRead less
Uncovering a novel memory process mediating stimulus-based decisions. The project aims to describe how environmental stimuli influence choice between actions. The goal is to demonstrate that this influence recruits a novel form of memory characterised by a durable change in the expression of an opioid receptor. It will combine sophisticated behavioural tasks with modern genetic tools in rodents to identify the molecular, cellular and neural interactions underlying the acquisition, maintenance an ....Uncovering a novel memory process mediating stimulus-based decisions. The project aims to describe how environmental stimuli influence choice between actions. The goal is to demonstrate that this influence recruits a novel form of memory characterised by a durable change in the expression of an opioid receptor. It will combine sophisticated behavioural tasks with modern genetic tools in rodents to identify the molecular, cellular and neural interactions underlying the acquisition, maintenance and retrieval of this memory. The project expects to provide new insights into the brain machinery promoting motivated behaviours and adaptive decision-making, and to extend knowledge about the physiological underpinnings of our memories. Read moreRead less
Gut-brain control of cue-induced feeding behaviours. This proposal aims to determine how food cues (e.g., advertisements) trigger our desire to eat. Using modern virally-mediated strategies, behavioural and histological techniques in a transgenic rat, this proposal seeks to characterise novel gut-brain circuits that mediate cue-induced feeding behaviours. This is significant as food cues can cause overeating, which is problematic in the current obesogenic society, yet the mechanisms are unclear. ....Gut-brain control of cue-induced feeding behaviours. This proposal aims to determine how food cues (e.g., advertisements) trigger our desire to eat. Using modern virally-mediated strategies, behavioural and histological techniques in a transgenic rat, this proposal seeks to characterise novel gut-brain circuits that mediate cue-induced feeding behaviours. This is significant as food cues can cause overeating, which is problematic in the current obesogenic society, yet the mechanisms are unclear. This project expects to provide new knowledge on how the gut communicates with multiple brain regions to control cue-induced eating. This work should benefit the advancement of knowledge and establish a framework for future research on gut-brain mechanisms in cue-induced feeding.Read moreRead less
Insect-inspired flapping wing robots: autonomous flight control systems. This project aims to design a novel control scheme for insect-inspired, flapping-wing, micro aerial vehicles. This type of micro aerial vehicle has complex, periodic, time-varying and inherently unstable dynamics, which are practically challenging to model and implement in hardware. This project will design energy-based automatic stabilization and task-dependent control, and develop the insect-inspired platform for testing ....Insect-inspired flapping wing robots: autonomous flight control systems. This project aims to design a novel control scheme for insect-inspired, flapping-wing, micro aerial vehicles. This type of micro aerial vehicle has complex, periodic, time-varying and inherently unstable dynamics, which are practically challenging to model and implement in hardware. This project will design energy-based automatic stabilization and task-dependent control, and develop the insect-inspired platform for testing nonlinear control strategies. The expected outcomes will include new system and control theories, concepts, principles and technologies in controller design that can provide reliable flight control for bio-inspired, flapping-wing systems.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100778
Funder
Australian Research Council
Funding Amount
$390,000.00
Summary
Mapping the neural circuits that underlie emotional learning. This project aims to understand the precise neural circuits that mediate the formation of emotional memories. Recent findings have identified a novel complexity in these circuits and the goal of this proposal is to resolve the underlying mechanism that drives emotional memories. In detail, this project will combine state of the art dual- optical stimulation techniques combined with behaviour-dependent tagging of neurons to investigate ....Mapping the neural circuits that underlie emotional learning. This project aims to understand the precise neural circuits that mediate the formation of emotional memories. Recent findings have identified a novel complexity in these circuits and the goal of this proposal is to resolve the underlying mechanism that drives emotional memories. In detail, this project will combine state of the art dual- optical stimulation techniques combined with behaviour-dependent tagging of neurons to investigate the precise brain circuits linked to emotional learning, an approach that also allows knowledge transfer to other research fields. Expected outcomes and benefits of the project is a significant shift in our understanding of the neural mechanisms that underlie emotional learning.Read moreRead less
Fast Precision Robust Control of Resonant Flexible Systems. The project aims to produce new control system design tools to enable fast precision control of advanced engineering systems encorporating flexible structures. This should enable improved speed and accuracy in control systems for precision instruments such as atomic force microscopes along with improving control system performance in areas of precision engineering such as semiconductor manufacturing, robotics and microelectromechanical ....Fast Precision Robust Control of Resonant Flexible Systems. The project aims to produce new control system design tools to enable fast precision control of advanced engineering systems encorporating flexible structures. This should enable improved speed and accuracy in control systems for precision instruments such as atomic force microscopes along with improving control system performance in areas of precision engineering such as semiconductor manufacturing, robotics and microelectromechanical systems. The outcomes are expected to be new control system synthesis and modelling tools enabling fast and highly accurate control of industrial systems using nonlinear and switching elements and achieving high levels of robustness. This will benefit Australian precision manufacturing industries.Read moreRead less