Coding of olfactory information in the piriform cortex. This project aims to understand how electrical activity in the primary olfactory (piriform) cortex enables mice to recognise and remember odours. By using optical recording techniques together with genetic tools, the project expects to generate new knowledge about how the mammalian brain builds internal representations of the external world. Specific outcomes of the project include new insights into the functional architecture of the pirifo ....Coding of olfactory information in the piriform cortex. This project aims to understand how electrical activity in the primary olfactory (piriform) cortex enables mice to recognise and remember odours. By using optical recording techniques together with genetic tools, the project expects to generate new knowledge about how the mammalian brain builds internal representations of the external world. Specific outcomes of the project include new insights into the functional architecture of the piriform cortex and fresh understanding of how olfactory information is encoded and stored in neural circuits. More broadly, the project aims to advance our understanding of how the brain works, with benefits for future improvements in artificial intelligence and brain-machine interfaces.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882701
Funder
Australian Research Council
Funding Amount
$300,000.00
Summary
Establishment of a confocal/multiphoton microscope for imaging of living systems. This facility will allow us to study the dynamic changes in living systems, from the smallest unicellular organisms in the ocean through to the sophisticated neural networks of the living brain. Not only will this imaging facility allow us to understand how living systems work, we will also be able to explore the dynamic changes that underlie human disease and injury.
Neuronal activity underlying efficient sensory processing. This project aims to study how neuronal activity in the sensory cortex efficiently represents the external world. Operating with a finite quantity of attentional resources, the brain needs to prioritise processing to provide important information about a situation. This project combines neurophysiology, behavioural and computational sciences to study attention mechanisms in rodents. This multidisciplinary project aims to develop a novel ....Neuronal activity underlying efficient sensory processing. This project aims to study how neuronal activity in the sensory cortex efficiently represents the external world. Operating with a finite quantity of attentional resources, the brain needs to prioritise processing to provide important information about a situation. This project combines neurophysiology, behavioural and computational sciences to study attention mechanisms in rodents. This multidisciplinary project aims to develop a novel paradigm for studying sensory prioritisation in rodents as a model organism.Read moreRead less
Preventing railway suicide: An open-systems perspective. Preventing railway suicide: An open-systems perspective. This project aims to develop an automated suicide risk detection system to reduce the incidence and impact of railway suicide, which has a devastating effect on victims’ families, station staff, train drivers, emergency workers, and bystanders. This project will use open-systems theory to develop two complementary information systems for more effective detection and reporting of suic ....Preventing railway suicide: An open-systems perspective. Preventing railway suicide: An open-systems perspective. This project aims to develop an automated suicide risk detection system to reduce the incidence and impact of railway suicide, which has a devastating effect on victims’ families, station staff, train drivers, emergency workers, and bystanders. This project will use open-systems theory to develop two complementary information systems for more effective detection and reporting of suicide risk; use these systems to investigate how different situational factors interact with different combinations of service interventions to influence suicide risk; and share the findings to reduce railway suicide in Australia and overseas.Read moreRead less
How do myelinating cells alter brain circuits to facilitate learning? This project aims to identify the brain circuits that receive new insulation and characterise the molecular mediators of this process. This project will apply innovative technologies to understand how the nervous system remains adaptable throughout life. This new knowledge, of the cellular mechanisms that allow brain circuits to remain adaptable throughout life, may have application in the development of interventions aimed at ....How do myelinating cells alter brain circuits to facilitate learning? This project aims to identify the brain circuits that receive new insulation and characterise the molecular mediators of this process. This project will apply innovative technologies to understand how the nervous system remains adaptable throughout life. This new knowledge, of the cellular mechanisms that allow brain circuits to remain adaptable throughout life, may have application in the development of interventions aimed at improving educational outcomes or counteracting age-related memory decline. Potential future benefits include facilitating the development of drugs to circumvent memory loss resulting from brain diseases, and improving the design of neuromorphic hardware for computing.Read moreRead less
Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS rese ....Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS research including epidemiology, immunology and neurobiology. Collaboration of 8 major Australian institutions is also important for this project and future studies. The team will have access to a new national MS GeneBank (platform) with samples from 2240 patients that should generate findings important to world-wide MS genetic knowledge.Read moreRead less
The key strategies in firms' realisation of value from ICT: A transformational model of ICT value generation. Studies indicate that information and communication technologies (ICT) have contributed significantly to Australia's productivity gains over the last decade. It is not well understood, however, why some firms and some industries have been able to benefit significantly more from ICT use than others. This study will show the strategies and practices that are used by the firms that gain max ....The key strategies in firms' realisation of value from ICT: A transformational model of ICT value generation. Studies indicate that information and communication technologies (ICT) have contributed significantly to Australia's productivity gains over the last decade. It is not well understood, however, why some firms and some industries have been able to benefit significantly more from ICT use than others. This study will show the strategies and practices that are used by the firms that gain maximum benefit from ICT - the 'ICT winners'. The lessons learned will allow other firms to gain further benefits from ICT, potentially leading overall to further economic gains by industries and the nation. Read moreRead less
A theory of communicative practices within financial internet discussion site communities. This project aims to use online financial investment communities to identify factors that drive communication and influence knowledge co-creation, examine how systematic variations in these factors influence investor decision making, and develop a mid-range theory for explaining and predicting the influence of online communication patterns on individual decisions and market outcomes. By developing and vali ....A theory of communicative practices within financial internet discussion site communities. This project aims to use online financial investment communities to identify factors that drive communication and influence knowledge co-creation, examine how systematic variations in these factors influence investor decision making, and develop a mid-range theory for explaining and predicting the influence of online communication patterns on individual decisions and market outcomes. By developing and validating a new mid-range theory, initially in the financial investment context, this project will provide significant benefits, such as help to secure Australia’s place in a changing world through improved information flow.Read moreRead less
A novel cooperative global information system for healthcare. This project will develop a global model for healthcare based on the groundbreaking Protocol Hypothesis Testing (PHT) system, allowing expert groups of clinicians to create and share knowledge across organizations. The PHT is a unique functioning knowledge management system that allows clinicians to record patient and treatment data as it is generated in clinical practice and applies scientific methods to generate clinical knowledge, ....A novel cooperative global information system for healthcare. This project will develop a global model for healthcare based on the groundbreaking Protocol Hypothesis Testing (PHT) system, allowing expert groups of clinicians to create and share knowledge across organizations. The PHT is a unique functioning knowledge management system that allows clinicians to record patient and treatment data as it is generated in clinical practice and applies scientific methods to generate clinical knowledge, all in real-time. The project will develop and test a framework for the PHT system to be used cooperatively by expert groups across virtual organizations, refining the PHT system in the process.Read moreRead less
Modelling, Identification and Control of Complex Networks. Australia has been well known for its leading research in systems and control and many real-world applications in, for instance, telecommunications, defence, power grids and life sciences. This project will further promote Australia's leading position in the emerging new research field - complex networks by theoretical breakthrough in modelling, identification and control of complex networks, and cutting-edge platform technology that can ....Modelling, Identification and Control of Complex Networks. Australia has been well known for its leading research in systems and control and many real-world applications in, for instance, telecommunications, defence, power grids and life sciences. This project will further promote Australia's leading position in the emerging new research field - complex networks by theoretical breakthrough in modelling, identification and control of complex networks, and cutting-edge platform technology that can help Australian energy industry to reduce greenhouse emissions. It will also result in education of the next generation research leaders in this emerging field.Read moreRead less