Transcriptional control of neural stem cell differentiation during development and disease. Understanding the molecular mechanisms that control how neural stem cells differentiate is critical to provide potential therapeutic treatment for neurodegenerative diseases and for brain cancer. This project will aim to discover, using an animal model system, the genes and molecules regulating these key biological processes.
Operation of nerve cell networks in the neocortex. In humans, intellectual disabilities occur when nerve cells in the neocortex, the most complicated area of the brain, fail to function correctly. The goal of this project is to understand how neocortical areas communicate and how changes in the structure of neurons disturb their function; work that will lead to a better understanding of the operation of the neocortex.
Molecular basis of glutamate receptor trafficking in neuronal plasticity . Neurons communicate via synapses, where chemicals (such as glutamate) are released to transmit neuronal signals. This proposal is aimed at understanding the molecular mechanisms of neuronal communication and adaptive plasticity, which are essential for normal brain function. The proposed research will combine biophysical, biochemical, molecular and cell biological assays to elucidate how the trafficking of glutamate recep ....Molecular basis of glutamate receptor trafficking in neuronal plasticity . Neurons communicate via synapses, where chemicals (such as glutamate) are released to transmit neuronal signals. This proposal is aimed at understanding the molecular mechanisms of neuronal communication and adaptive plasticity, which are essential for normal brain function. The proposed research will combine biophysical, biochemical, molecular and cell biological assays to elucidate how the trafficking of glutamate receptors is regulated in neurons during plasticity and learning. The outcomes will enhance our understanding of how neural plasticity is generated and maintained, knowledge that is critical for our understanding of the cellular correlates of information, sensory and motor processing, as well as learning, memory and cognition.Read moreRead less
Toll-like receptors in infectious and inflammatory diseases: the double-edged sword of innate immunity. The innate immune system is the first line of defence against invading microorganisms. This project will explore the role of specific innate immune genes in the control of infections and the development of inflammatory diseases.
Inflammasomes: molecular drivers of anti-microbial defence. The innate immune system is the body’s first line of defence against infection, but also drives unhealthy inflammation. Families of innate immune receptors, such as nucleotide-binding oligomerisation domain (NOD-like Receptors), were recently discovered to control both anti-microbial defence and unhealthy inflammation. This project will characterise the basic biology of NOD-like Receptors at the molecular, cellular and organismal levels ....Inflammasomes: molecular drivers of anti-microbial defence. The innate immune system is the body’s first line of defence against infection, but also drives unhealthy inflammation. Families of innate immune receptors, such as nucleotide-binding oligomerisation domain (NOD-like Receptors), were recently discovered to control both anti-microbial defence and unhealthy inflammation. This project will characterise the basic biology of NOD-like Receptors at the molecular, cellular and organismal levels, and will thereby lead to a greater understanding of the fundamental biological pathways controlling inflammation and defence against infection. This may ultimately lead to commercial opportunities for treating infection and chronic inflammation.Read moreRead less
Computer-Aided Design of High-Performance Photocatalysts for Solar Hydrogen Production Based on Red Titanium Dioxide. Large-scale generation of energy by solar conversion is critical for future sustainability. This project aims to develop high performance materials to efficiently convert solar energy to hydrogen - a clean fuel. Starting from the newly developed material red titanium dioxide, novel strategies for improved photocatalytic materials will be proposed and evaluated by advanced computa ....Computer-Aided Design of High-Performance Photocatalysts for Solar Hydrogen Production Based on Red Titanium Dioxide. Large-scale generation of energy by solar conversion is critical for future sustainability. This project aims to develop high performance materials to efficiently convert solar energy to hydrogen - a clean fuel. Starting from the newly developed material red titanium dioxide, novel strategies for improved photocatalytic materials will be proposed and evaluated by advanced computational approaches. Key issues for solar-to-hydrogen conversion will be clarified. The materials, knowledge and strategies achieved by this project will dramatically enhance current solar technology and in particular will advance the development of low-cost hydrogen production from water. Read moreRead less
Transformer 3D Nanostructures: Stimuli Responsive Polymers. This research program will develop smart nanostructures that will be capable of producing high value added products using cheap polymer materials but achieving a much greater design capacity for end-use functions. The knowledge gained from this project will have potential applications in many areas where nanomaterials and polymers are used, including high strength coatings, conducting coatings for the electronic industry, drug and vacci ....Transformer 3D Nanostructures: Stimuli Responsive Polymers. This research program will develop smart nanostructures that will be capable of producing high value added products using cheap polymer materials but achieving a much greater design capacity for end-use functions. The knowledge gained from this project will have potential applications in many areas where nanomaterials and polymers are used, including high strength coatings, conducting coatings for the electronic industry, drug and vaccine delivery devices, tissue scaffolds, nanosensors, and gene delivery. These polymer techniques will enable Australian Industry to significantly improve product performance by providing advanced features and capabilities previously unavailable.Read moreRead less
Plasmonic nanoparticle catalysis for nitrogen-based synthesis. Light can generate an optical force to capture small objects. This requires intense light – a laser, which limits optical trapping in catalysis applications. This project aims to apply plasmonic nanoparticles with normal-intensity light to take advantage of plasmonic-generated optical forces for catalytic chemical synthesis. The optical trapping/releasing of small molecules is highly selective and responsive to molecule structure and ....Plasmonic nanoparticle catalysis for nitrogen-based synthesis. Light can generate an optical force to capture small objects. This requires intense light – a laser, which limits optical trapping in catalysis applications. This project aims to apply plasmonic nanoparticles with normal-intensity light to take advantage of plasmonic-generated optical forces for catalytic chemical synthesis. The optical trapping/releasing of small molecules is highly selective and responsive to molecule structure and so presents a great opportunity to radically alter chemical synthesis pathways, which will be illustrated with reactions on liquid-solid and gas-solid interfaces. This highly innovative strategy will be used to discover new nitrogen-based syntheses which are both fundamentally and industrially important.Read moreRead less
Molecules and mechanisms regulating axonal degeneration and regeneration in Caenorhabditis elegans neurons. Understanding the molecular mechanisms underlying nerve degeneration and regeneration is essential to tackle and provide treatment for neurodegenerative diseases and injury of the nervous system. This project aims to discover, using a genetic approach and a simple animal model system, the molecules regulating these crucial biological processes.
Genetic dissection of cardiac morphogenesis. The human heart is critical for survival and yet, despite its importance, we still lack a basic understanding of how it forms. This project aims to discover new genes involved in cardiac development so we can understand how to build a heart. Armed with this information, this research will assist in devising strategies for the repair of congenital and acquired heart disease.