Enhancing immunogenicity of DNA vaccines by targeted delivery to antigen presenting cells. Vaccines have proven to be one of the most effective means of preventing infection and also provide promise as a treatment for cancer. However, the range of effective technologies that make possible the delivery of vaccines that can protect against a broad range of infections is limited. DNA based vaccines are attractive because they are relatively easy to produce against a wide range of infections. Howeve ....Enhancing immunogenicity of DNA vaccines by targeted delivery to antigen presenting cells. Vaccines have proven to be one of the most effective means of preventing infection and also provide promise as a treatment for cancer. However, the range of effective technologies that make possible the delivery of vaccines that can protect against a broad range of infections is limited. DNA based vaccines are attractive because they are relatively easy to produce against a wide range of infections. However, DNA vaccines often provide poor protection against infections. This project will explore a unique technology developed in Australia and that will greatly improve the effectiveness of DNA vaccines against a broad range of diseases. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100165
Funder
Australian Research Council
Funding Amount
$451,900.00
Summary
Engineering T cells to promote peripheral immunity. Tissue-resident memory T cells (TRM) are key for immune protection against infections and cancer. This has led to much interest in understanding how these immune cells develop, although elucidation of molecules that regulate TRM are still scarce. This project aims to (i) identify genetic drivers of TRM in peripheral organs and (ii) modulate TRM generation utilising state-of-the-art genetic engineering techniques. Expected outcomes include gener ....Engineering T cells to promote peripheral immunity. Tissue-resident memory T cells (TRM) are key for immune protection against infections and cancer. This has led to much interest in understanding how these immune cells develop, although elucidation of molecules that regulate TRM are still scarce. This project aims to (i) identify genetic drivers of TRM in peripheral organs and (ii) modulate TRM generation utilising state-of-the-art genetic engineering techniques. Expected outcomes include generating new knowledge that will contribute to the development of novel therapeutics against infectious disease and cancer, together with the benefit of promoting national and international collaboration with the ultimate goal of improving health.Read moreRead less
Special Research Initiatives - Grant ID: SR0354678
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
Australian Initiative for Malaria (AIM). Malaria is a major global health problem with 500 million people infected and 2-3 million deaths per year. Australia has an extraordinary capacity in malaria research publishing more papers per capita than any other country. The Australian Initiative for Malaria will weld this critical mass into a stronger and more cohesive unit better able to capitalise on new developments in malaria research and will allow us to tackle the enormous problem malaria pre ....Australian Initiative for Malaria (AIM). Malaria is a major global health problem with 500 million people infected and 2-3 million deaths per year. Australia has an extraordinary capacity in malaria research publishing more papers per capita than any other country. The Australian Initiative for Malaria will weld this critical mass into a stronger and more cohesive unit better able to capitalise on new developments in malaria research and will allow us to tackle the enormous problem malaria presents to our region. We will integrate our research expertise with regional laboratories in PNG, E Timor, Solomon Is, Indonesia and Thailand.Read moreRead less
Characterisation and development of adjuvants for new generation veterinary and human vaccines. Vaccination is the most successful and cost-effective means of combating infectious diseases in both veterinary and human medicine. This project will increase our understanding of how vaccines work and will help the development of new vaccines against infections in both animals and man. The results of these studies will also increase the competitiveness of Australian scientists in the field of vaccine ....Characterisation and development of adjuvants for new generation veterinary and human vaccines. Vaccination is the most successful and cost-effective means of combating infectious diseases in both veterinary and human medicine. This project will increase our understanding of how vaccines work and will help the development of new vaccines against infections in both animals and man. The results of these studies will also increase the competitiveness of Australian scientists in the field of vaccine research and development.Read moreRead less
Identifying the major targets of protective antibodies against malaria. This project aims to understand how immunity to malaria develops and to use this knowledge to develop effective vaccines against malaria. The development of a malaria vaccine would be of great value in Australia's region where malaria is a leading cause of death and illness and impairs economic development. The project will advance our knowledge of how the immune system fights infections and will contribute to building Austr ....Identifying the major targets of protective antibodies against malaria. This project aims to understand how immunity to malaria develops and to use this knowledge to develop effective vaccines against malaria. The development of a malaria vaccine would be of great value in Australia's region where malaria is a leading cause of death and illness and impairs economic development. The project will advance our knowledge of how the immune system fights infections and will contribute to building Australia's strength in infectious diseases research and developing strategies to combat important infections. The project will help build and maintain expertise in developing vaccines in Australia and the approaches used and knowledge gained will be applicable to understanding and combating other important infections.Read moreRead less