Understanding the molecular mechanisms regulating neuronal fusion. Neurons are tightly connected individual cells that communicate through chemical and electrical signals, and this project aims to discover the key molecules that allow these cells to remain as individual units without fusing with each other. The nervous system, unlike other tissues, is made of discrete individual cells, connected by chemical and electrical synapses but not by cytoplasmic continuity. However, how this is achieved ....Understanding the molecular mechanisms regulating neuronal fusion. Neurons are tightly connected individual cells that communicate through chemical and electrical signals, and this project aims to discover the key molecules that allow these cells to remain as individual units without fusing with each other. The nervous system, unlike other tissues, is made of discrete individual cells, connected by chemical and electrical synapses but not by cytoplasmic continuity. However, how this is achieved and how neurons maintain their individuality during development, remodelling and ageing is unknown. The project aims to address this gap using a genetic approach and the nematode Caenorhabditis elegans as an experimental system. The results may provide insights into how the nervous system develops and functions.Read moreRead less
Cellular Cross-talk Between Liver Progenitor Cells And Hepatic Stellate Cells Is Required For Hepatic Fibrogenesis
Funder
National Health and Medical Research Council
Funding Amount
$618,517.00
Summary
Deloitte Access Economics data proposes the total economic burden of liver disease in Australia in 2012 was >$50 billion. This study will identify how the liver heals itself by inducing liver cell populations which interact to regenerate damaged liver tissue in chronic liver disease. This knowledge may lead to the development of novel therapeutic interventions for the treatment of liver scarring and liver cancer, and to assist in normal liver regeneration following chronic liver disease.
Interactions between phenome and genome at developing CNS synapses during synaptic refinement. Activity-dependent changes in synaptic transmission are vital to development and function of central neuronal networks. However, the critical factors regulating developmental changes in synaptic signals remain largely unknown. We will correlate functional changes in synaptic responses at glutamate-releasing synapses with changes in glutamate receptor composition at a critical period during developmen ....Interactions between phenome and genome at developing CNS synapses during synaptic refinement. Activity-dependent changes in synaptic transmission are vital to development and function of central neuronal networks. However, the critical factors regulating developmental changes in synaptic signals remain largely unknown. We will correlate functional changes in synaptic responses at glutamate-releasing synapses with changes in glutamate receptor composition at a critical period during development, test whether synaptic activation of receptors is required for these changes and define the pattern of activity-dependent changes in gene expression necessary for developmental changes in synaptic transmission. Understanding this interaction between synaptic phenome and activity-dependent genomic expression will expand our understanding of brain development and function.Read moreRead less
Cultural responsiveness: measuring and evaluating social work practice. This project aims to develop tools for use by social workers that measure and evaluate culturally responsive practices with Aboriginal and Torres Strait Islander peoples. The tools have potential application across numerous sectors in social work practices with clients and families. The project will benefit social workers who can measure, evaluate and improve their culturally responsive practice, and in turn, the health and ....Cultural responsiveness: measuring and evaluating social work practice. This project aims to develop tools for use by social workers that measure and evaluate culturally responsive practices with Aboriginal and Torres Strait Islander peoples. The tools have potential application across numerous sectors in social work practices with clients and families. The project will benefit social workers who can measure, evaluate and improve their culturally responsive practice, and in turn, the health and well-being outcomes for Aboriginal and Torres Strait Islander peoples.Read moreRead less
Development of novel reagents that specifically counteract EphA4 to enhance axonal regeneration. This project will examine the role of EphA4, an important guidance protein, in neural cell regeneration. The goal is to understand the signalling mechanisms that inhibit regeneration in the central nervous system and to develop novel biological agents to overcome these processes and promote functional recovery after nervous system injury or disease.
Click chemistry to reveal how neurons and glia shape perineuronal nets . The extracellular matrix (ECM) and its perineuronal nets (which are net-like structures with holes wrapped around neurons) are largely underexplored, despite representing a remarkable 20% of the brain’s total volume and having been suggested to be involved in many brain functions. Interestingly, digestion of the ECM improves learning and memory, but deficits return once the ECM has reformed. However, how this ECM remodellin ....Click chemistry to reveal how neurons and glia shape perineuronal nets . The extracellular matrix (ECM) and its perineuronal nets (which are net-like structures with holes wrapped around neurons) are largely underexplored, despite representing a remarkable 20% of the brain’s total volume and having been suggested to be involved in many brain functions. Interestingly, digestion of the ECM improves learning and memory, but deficits return once the ECM has reformed. However, how this ECM remodelling is organised at a cell-type level is not understood. Here we aim to close this knowledge gap, using cutting-edge technology including bioconjugation and ultrasound-mediated cargo delivery. Together, this project aims to contribute to a deeper understanding of this major brain compartment in neuronal function. Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH210100040
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC RESEARCH HUB FOR CONNECTED SENSORS FOR HEALTH. This Hub aims to develop, manufacture and deploy high-tech, cyber-secure, medically-certified IoT sensors to global health markets by integrating disparate Australian capabilities into a productive end-to-end value chain. This Hub expects to position Australia at the forefront of connected health by integrating sensor science with cyber-secure data analytics, regulatory approval and certified manufacturing capabilities. Expected outcomes of this ....ARC RESEARCH HUB FOR CONNECTED SENSORS FOR HEALTH. This Hub aims to develop, manufacture and deploy high-tech, cyber-secure, medically-certified IoT sensors to global health markets by integrating disparate Australian capabilities into a productive end-to-end value chain. This Hub expects to position Australia at the forefront of connected health by integrating sensor science with cyber-secure data analytics, regulatory approval and certified manufacturing capabilities. Expected outcomes of this Hub include advanced manufacturing capacity for connected sensors, strategic partnerships and commercialisation skills to translate sensors research to create economic benefits such as jobs and locally-made products for domestic and export markets, as well as improving the health of Australians.Read moreRead less
Early Career Industry Fellowships - Grant ID: IE230100135
Funder
Australian Research Council
Funding Amount
$448,222.00
Summary
Developing strong, robust and high performing women football players. Women drop out of Australian football at a higher rate than men, often due to concerns about their physical capabilities and performance. Yet, coaches do not prioritise developing physical capacity (eg strength), due to perceived lack of relevance to football. In community Australian football players, this study will identify physical capacity elements relevant for football performance, assess the change across a typical seaso ....Developing strong, robust and high performing women football players. Women drop out of Australian football at a higher rate than men, often due to concerns about their physical capabilities and performance. Yet, coaches do not prioritise developing physical capacity (eg strength), due to perceived lack of relevance to football. In community Australian football players, this study will identify physical capacity elements relevant for football performance, assess the change across a typical season and the influence of gender and age. Combining sport science and engineering, smartphone videos and open-access software will be utilised to develop cost-effective methods to assess tackling skill. Findings will inform better training strategies for women, reducing injury, enhancing retention and physical activity. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100998
Funder
Australian Research Council
Funding Amount
$444,576.00
Summary
Should I stay or should I go? How brain stem cells leave quiescence. Most adult stem cells in our brains are sleeping (quiescent). Quiescence helps ensure animals have a lifelong population of brain stem cells, which is crucial for the maintenance of brain circuitry. This project aims to investigate how this process is regulated at a molecular level. This project expects to define the molecular playbook controlling quiescence and explain why brain stem cells progress into deeper states of quiesc ....Should I stay or should I go? How brain stem cells leave quiescence. Most adult stem cells in our brains are sleeping (quiescent). Quiescence helps ensure animals have a lifelong population of brain stem cells, which is crucial for the maintenance of brain circuitry. This project aims to investigate how this process is regulated at a molecular level. This project expects to define the molecular playbook controlling quiescence and explain why brain stem cells progress into deeper states of quiescence during aging by combining novel tissue culture and genetic models, where brain stem cells have disrupted quiescence, with innovative methods of reading gene expression. The benefits of these outcomes include the development of methods to control the quiescence of brain stem cells for bioengineering purposes.Read moreRead less
Pathways To Mental Health And Obesity In Young Adults: A Longitudinal Study
Funder
National Health and Medical Research Council
Funding Amount
$698,510.00
Summary
While the health of the population has been gradually improving, there are some health problems which are increasing. The mental health of young people is one such area. Based on data relating to youth suicide, substance abuse, cigarette smoking by females and behavioural or mental health problems in the young, there has been evidence of a marked increase in some important health problems faced by the young. Little is known about the causes of these problems and even less is known about the reas ....While the health of the population has been gradually improving, there are some health problems which are increasing. The mental health of young people is one such area. Based on data relating to youth suicide, substance abuse, cigarette smoking by females and behavioural or mental health problems in the young, there has been evidence of a marked increase in some important health problems faced by the young. Little is known about the causes of these problems and even less is known about the reasons for the increase. Based on the available evidence, 20-25% of young persons manifest a mental health problem. A second area of marked health deterioration concerns youth (and adult) obesity. Existing research points to the accumulation of cardiovascular risk factors associated with obesity from a very early age. Over 10% of youth are obese and a substantially higher proportion are overweight. There is evidence that the rate of obesity has been substantially increasing. Again little is known about the factors that contribute to obesity or the causes of the increase in the rates of obesity in the population. This proposal is for a 21-year follow-up of a sample of youth first enrolled when their mothers attended for their first obstetrical visit. Using a substantial body of existing data, we propose to examine the changes in levels of mental health and obesity and to identify the factors which contribute to these changes. This study involves the largest Australian cohort ever assembled for such research. The main questions asked in this study concern the impact of the mother's social and economic circumstances, her physical health and well-being, her use of addictive substances (including alcohol, cigarettes, illicit drugs) on the youth's health. We will also examine the association between early indicators of mental health and well-being and subsequent youth health and development.Read moreRead less