Electrical properties of human dendrites. This project aims to determine the electrical properties of dendrites in human neurons. Dendrites are the primary site of synaptic input to neurons and their electrical properties play a key role in information processing in the brain. While we know much about the electrical properties of dendrites in other species, primarily rodents, little is known about the electrical properties of human dendrites. This project aims to address this gap in knowledge fo ....Electrical properties of human dendrites. This project aims to determine the electrical properties of dendrites in human neurons. Dendrites are the primary site of synaptic input to neurons and their electrical properties play a key role in information processing in the brain. While we know much about the electrical properties of dendrites in other species, primarily rodents, little is known about the electrical properties of human dendrites. This project aims to address this gap in knowledge for the first time. The results obtained will shed light on the mechanisms the brain uses to process information, and therefore will bring us a step closer to truly understanding ourselves.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100077
Funder
Australian Research Council
Funding Amount
$441,935.00
Summary
A geospatial toolkit to assess community risk to environmental change. This project seeks to strengthen our understanding of the role of environmental change in driving patterns of community risk, by building a spatially and temporally explicit model, and a risk index that will be designed with input from decision makers. This project expects to improve the implementation of geospatial tools for risk assessment using an innovative approach based on evidence and practice. Expected outcomes includ ....A geospatial toolkit to assess community risk to environmental change. This project seeks to strengthen our understanding of the role of environmental change in driving patterns of community risk, by building a spatially and temporally explicit model, and a risk index that will be designed with input from decision makers. This project expects to improve the implementation of geospatial tools for risk assessment using an innovative approach based on evidence and practice. Expected outcomes include increased and optimal implementation of geospatial data in Australian systems, and enhanced research capacity to proactively respond to environmental change.Read moreRead less
Role of the superior colliculus in sensory processing. The ability of an organism to attend to, and orient towards, stimuli in the environment is critical for survival. In the mammalian brain, the principal brain region performing this function is the superior colliculus. Despite its importance, little is known about the role the superior colliculus plays in sensory perception. This project addresses this issue by leveraging revolutionary new recording techniques to determine how the superior co ....Role of the superior colliculus in sensory processing. The ability of an organism to attend to, and orient towards, stimuli in the environment is critical for survival. In the mammalian brain, the principal brain region performing this function is the superior colliculus. Despite its importance, little is known about the role the superior colliculus plays in sensory perception. This project addresses this issue by leveraging revolutionary new recording techniques to determine how the superior colliculus codes sensory information and ultimately drives behaviour. The outcomes will be of immediate benefit to scientists studying sensory processing and perceptual decision making, and will help keep Australia at the forefront of brain-inspired engineering and the neuroscience-based knowledge economy.Read moreRead less
Coding of olfactory information in the piriform cortex. This project aims to understand how electrical activity in the primary olfactory (piriform) cortex enables mice to recognise and remember odours. By using optical recording techniques together with genetic tools, the project expects to generate new knowledge about how the mammalian brain builds internal representations of the external world. Specific outcomes of the project include new insights into the functional architecture of the pirifo ....Coding of olfactory information in the piriform cortex. This project aims to understand how electrical activity in the primary olfactory (piriform) cortex enables mice to recognise and remember odours. By using optical recording techniques together with genetic tools, the project expects to generate new knowledge about how the mammalian brain builds internal representations of the external world. Specific outcomes of the project include new insights into the functional architecture of the piriform cortex and fresh understanding of how olfactory information is encoded and stored in neural circuits. More broadly, the project aims to advance our understanding of how the brain works, with benefits for future improvements in artificial intelligence and brain-machine interfaces.Read moreRead less
Exploring Wellbeing Outcomes in the Aquatic and Recreation Industry. This project aims to investigate the impact on individual wellbeing through use of public aquatic and recreation centres in Australia. Through the use of mixed methods across multiple locations, the project expects to generate new knowledge on the effect on users of different management and service models for the provision of aquatic and recreational infrastructure. Expected outcomes include a quantifiable measure of social and ....Exploring Wellbeing Outcomes in the Aquatic and Recreation Industry. This project aims to investigate the impact on individual wellbeing through use of public aquatic and recreation centres in Australia. Through the use of mixed methods across multiple locations, the project expects to generate new knowledge on the effect on users of different management and service models for the provision of aquatic and recreational infrastructure. Expected outcomes include a quantifiable measure of social and emotional wellbeing that can be utilised by centre management and government. This will help assessment of best practice for maximising community wellbeing, and can guide investment decisions by state and local government.Read moreRead less
Using multiple data sources to understand the opioid crisis in Australia . This project aims to improve the quality and integration of population-level data for monitoring the consumption of opioids, licit and illicit, in Queensland communities. The analysis of opioids in wastewater, integrated with opioid use information such as prescription and seizure statistics will vastly increase knowledge of consumption patterns of opioids. By analysing wastewater samples from 2011 and triangulating with ....Using multiple data sources to understand the opioid crisis in Australia . This project aims to improve the quality and integration of population-level data for monitoring the consumption of opioids, licit and illicit, in Queensland communities. The analysis of opioids in wastewater, integrated with opioid use information such as prescription and seizure statistics will vastly increase knowledge of consumption patterns of opioids. By analysing wastewater samples from 2011 and triangulating with other datasets, the expected outcomes include building capacity to estimate consumption of all opioids; detecting the misuse of licit and illicit opioids over time. Anticipated benefit is to provide objective evidence of opioid use patterns for decision makers and a framework for a national opioids monitoring program.Read moreRead less
Tracking language development of Indigenous children in Central Australia. This project aims to identify language development paths of Indigenous children in Central Australia by examining the spoken language, gesture and sign of children’s early interactions. It expects to generate new knowledge for the health and education sector, and Indigenous families, about children’s language development, enabling reliable identification of typical development. Expected outcomes include theoretical contri ....Tracking language development of Indigenous children in Central Australia. This project aims to identify language development paths of Indigenous children in Central Australia by examining the spoken language, gesture and sign of children’s early interactions. It expects to generate new knowledge for the health and education sector, and Indigenous families, about children’s language development, enabling reliable identification of typical development. Expected outcomes include theoretical contributions to language and cognition internationally and uptake of the findings by Australian health and education sector staff and Indigenous communities. This should provide significant benefits to Indigenous families through increased capacity of families and professionals to identify service needs in language development.Read moreRead less
RNA-binding proteins rewire transcriptomes in immune cell differentiation. This project aims to combine advanced computational and experimental techniques to investigate a new layer of gene regulation by novel RNA binding proteins (RBP) which control messenger RNA length in immune cells. This project expects to demonstrate that these RBPs have a profound effect on immune cell differentiation and response to infection. Expected outcomes include the discovery of new RBPs regulating immunity, with ....RNA-binding proteins rewire transcriptomes in immune cell differentiation. This project aims to combine advanced computational and experimental techniques to investigate a new layer of gene regulation by novel RNA binding proteins (RBP) which control messenger RNA length in immune cells. This project expects to demonstrate that these RBPs have a profound effect on immune cell differentiation and response to infection. Expected outcomes include the discovery of new RBPs regulating immunity, with mechanism and function determined by novel CRISPR editing of a transgenic mouse model. The significant benefit will be a more complete understanding of RNA mechanisms of immune response, which will be critical in informing future advances in the rapidly developing areas of RNA-based biotechnologies and synthetic immunology.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100001
Funder
Australian Research Council
Funding Amount
$875,000.00
Summary
A 3-photon imaging system for deep live imaging. This project aims to establish Australia’s first 3-photon microscope system with adaptive optics for deep intravital imaging. This advanced imaging system will enable researchers to investigate the biology of cells and tissue structures in a wide range of organs and engineered tissues, to a degree not possible with existing technology. This project will capitalise on advanced laser, microscope and adaptive optics technologies with the expected out ....A 3-photon imaging system for deep live imaging. This project aims to establish Australia’s first 3-photon microscope system with adaptive optics for deep intravital imaging. This advanced imaging system will enable researchers to investigate the biology of cells and tissue structures in a wide range of organs and engineered tissues, to a degree not possible with existing technology. This project will capitalise on advanced laser, microscope and adaptive optics technologies with the expected outcomes to include the generation of new knowledge of major biological systems, including the immune system and the nervous system. This will provide significant benefits to fundamental interdisciplinary research into immunology, infectious disease, neuroscience, mechanobiology and engineering.Read moreRead less