Investigating Wnt signaling during human nephron commitment and patterning. Aims: To use gene edited stem cell lines that display cell location, identity and cell state to map human kidney tissue formation in the laboratory. By monitoring how each cell responds to those around it across time and space, we will for the first time map the formation of kidney tissue in the dish.
Significance: Understanding how stem cells form a tissue will help us to improve and control the process. This is key to ....Investigating Wnt signaling during human nephron commitment and patterning. Aims: To use gene edited stem cell lines that display cell location, identity and cell state to map human kidney tissue formation in the laboratory. By monitoring how each cell responds to those around it across time and space, we will for the first time map the formation of kidney tissue in the dish.
Significance: Understanding how stem cells form a tissue will help us to improve and control the process. This is key to advancing tissue engineering.
Expected outcomes: The proposal will pioneer state-of-the-art imaging, gene editing and machine learning approaches, generating models of human development that are currently unavailable.
Benefits: This understanding will guide the development of novel approaches to tissue engineering.
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Australian Laureate Fellowships - Grant ID: FL160100170
Funder
Australian Research Council
Funding Amount
$2,887,531.00
Summary
Scaling in biology: size control at the cell, organelle and organism level. This project aims to decipher the universal mechanisms that coordinate growth with division and thereby dictate the size of the cell. It would investigate this question from the triangulating perspective of evolution using yeast and animal models. It plans to interrogate the complex sub-networks that govern cell size using novel genome-scale reagent sets for systematic genetics and other approaches. It would integrate th ....Scaling in biology: size control at the cell, organelle and organism level. This project aims to decipher the universal mechanisms that coordinate growth with division and thereby dictate the size of the cell. It would investigate this question from the triangulating perspective of evolution using yeast and animal models. It plans to interrogate the complex sub-networks that govern cell size using novel genome-scale reagent sets for systematic genetics and other approaches. It would integrate this data in predictive mathematical models of size control that illuminate how the cell processes size-related information, and how size mechanisms evolve to impact form and function in biology. This research is expected to have commercial applications in biotechnology processes and bioengineering.Read moreRead less
Improving predictions of species distribution dynamics. This project aims to mainstream methods for improved prediction of species distributions under the impacts of environmental change. This is important because these predictions are commonly used to guide environmental decisions, but the standard modelling methods used to produce them have critical limitations. This project intends to (i) make key statistical developments to methods for modelling dynamics of species distributions and (ii) tra ....Improving predictions of species distribution dynamics. This project aims to mainstream methods for improved prediction of species distributions under the impacts of environmental change. This is important because these predictions are commonly used to guide environmental decisions, but the standard modelling methods used to produce them have critical limitations. This project intends to (i) make key statistical developments to methods for modelling dynamics of species distributions and (ii) translate the methods into practice, through guidelines, tools and training, engagement with users and case studies addressing species of current concern. This should provide significant benefits because it will enable better decisions and more effective and cost-efficient management actions.Read moreRead less