Plasmin is a complex enzyme that performs major roles in removal of blood clots, wound healing and in tumor metastasis. Here we will understand how plasmin function is regulated at the molecular level. These key insights will be of future use in the development of therapeutics targeting the plasmin system in cancer and clotting diseases.
Matching flotation concentrate composition to downstream processing in copper production at the Olympic Dam operations of BHP Billiton. This research is important for the Australian and South Australian economies. There are both large capital and operating costs benefits if a successful and robust mineral separation can be achieved. Being able to separate different copper sulphide minerals in copper concentrates will have global significance. In the particular case of Olympic Dam mine, the imp ....Matching flotation concentrate composition to downstream processing in copper production at the Olympic Dam operations of BHP Billiton. This research is important for the Australian and South Australian economies. There are both large capital and operating costs benefits if a successful and robust mineral separation can be achieved. Being able to separate different copper sulphide minerals in copper concentrates will have global significance. In the particular case of Olympic Dam mine, the impact of being able to separate the copper sulphide minerals at the mineral processing stage is a significant reduction in operating costs, which is a result of reduced ore handling, mining and smelting costs.Read moreRead less
Separating gold from silica by tailored hydrometallurgical processes. Australia is one of the world's largest producers of gold, and the ability to more efficiently separate gold from its ores will benefit the Australian economy by maximising the value of every tonne of ore which is removed from the ground. Inefficiencies in processing technology can lead to the loss of gold from extraction processes, and the reasons for some of these losses are poorly understood but are believed to be related t ....Separating gold from silica by tailored hydrometallurgical processes. Australia is one of the world's largest producers of gold, and the ability to more efficiently separate gold from its ores will benefit the Australian economy by maximising the value of every tonne of ore which is removed from the ground. Inefficiencies in processing technology can lead to the loss of gold from extraction processes, and the reasons for some of these losses are poorly understood but are believed to be related to interactions between gold and silicate minerals. We will study these interactions with a view towards improving the percentage of gold present in the ores which is able to be extracted and used.Read moreRead less
Impact of recycled and low quality process water on sustainable mineral processing practices. Water is in short supply and needs to be considered as a 'key reagent'. The quality of this reagent can vary widely. For a sustainable mineral processing practice, the use of recycled or low quality/saline process water will be essential for a plant to operate in the future. The major benefit is recognition that significant recycle of process water for flotation is achievable if simple water quality con ....Impact of recycled and low quality process water on sustainable mineral processing practices. Water is in short supply and needs to be considered as a 'key reagent'. The quality of this reagent can vary widely. For a sustainable mineral processing practice, the use of recycled or low quality/saline process water will be essential for a plant to operate in the future. The major benefit is recognition that significant recycle of process water for flotation is achievable if simple water quality control and management practices are implemented. In addition, a better understanding and control of water quality in recycled/saline process water may lead to improved flotation stability and performance, and reduced reagent consumption.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100149
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
Spectroscopic imaging for materials, minerals and life sciences. The spectroscopic imaging equipment highlighted in this proposal will produce a number of outcomes of national benefit. First, it will elevate the impact of research in materials, minerals, and life sciences in Australia, all of which are key areas for the national economy and community. Second, the equipment will be integral to the teaching and research nexus and experiential learning facility for a new wave of materials science ....Spectroscopic imaging for materials, minerals and life sciences. The spectroscopic imaging equipment highlighted in this proposal will produce a number of outcomes of national benefit. First, it will elevate the impact of research in materials, minerals, and life sciences in Australia, all of which are key areas for the national economy and community. Second, the equipment will be integral to the teaching and research nexus and experiential learning facility for a new wave of materials science and engineering students to be educated at UniSA in the EIF-funded M2 building at Mawson Lakes. Finally, the anticipated outcomes of the research to be supported are significant and relate clearly to a number of National Research Priorities.Read moreRead less
Australian Mineral Science Research Institute: Transformation of resource-based industries through the generation and application of new technologies. The research conducted within AMSRI will enable our existing resource-based industries to be transformed through the application of new technologies, helping to create an environmentally sustainable nation, a key national research priority. The research programs in energy efficient liberation, frugal water use and waste management, innovative proc ....Australian Mineral Science Research Institute: Transformation of resource-based industries through the generation and application of new technologies. The research conducted within AMSRI will enable our existing resource-based industries to be transformed through the application of new technologies, helping to create an environmentally sustainable nation, a key national research priority. The research programs in energy efficient liberation, frugal water use and waste management, innovative processing, material and interface science, advanced analysis and mathematics in minerals processing are of critical importance to Australia's major export industry. AMSRI will produce unique graduate students, educated in a multi-university, industry-linked research environment, who will provide a strong intellectual resource to both Australian industry and research institutions.Read moreRead less
A Novel Molecular Mechanism Controlling Myelopoiesis
Funder
National Health and Medical Research Council
Funding Amount
$878,439.00
Summary
The immune system is comprised of many different cell types, each with a specialised function. Many are short-lived and must be continually replenished throughout life. Abnormalities in this process underlie many human diseases, including immunodeficiency, autoimmunity and cancer. We have discovered a novel molecular mechanism that is critical for the production of immune cells. This project will investigate how this mechanism is controlled and the impacts on myelodysplastic syndromes.
Modulating Immune Responses By Targeting Dendritic Cells Using Dendritic Cell Specific Markers.
Funder
National Health and Medical Research Council
Funding Amount
$197,750.00
Summary
The ability to modulate immune responses would have major health benefits. Dendritic cells (DC) are key regulators of the immune system. Different types of DC possess different cell surface molecules and have differing regulatory functions. We have identified four novel DC surface molecules that can be used to target different types of DC. We aim to use antibodies against these molecules to either enhance the effectiveness of vaccines or to suppress autoimmune diseases.
Special Research Initiatives - Grant ID: SR180100030
Funder
Australian Research Council
Funding Amount
$1,103,883.00
Summary
Development of electrochemically activated sorbents for PFAS defluorination. This project aims to develop a new treatment technology to completely defluorinate per- and poly-fluroalkyl substances (PFAS) and to treat significant water quantities. The majority of existing water treatment technologies are unable to remove PFAS to the desired extent, are prohibitively expensive or are only useful for a very limited lifespan. This project is expected to develop a new treatment technology with the abi ....Development of electrochemically activated sorbents for PFAS defluorination. This project aims to develop a new treatment technology to completely defluorinate per- and poly-fluroalkyl substances (PFAS) and to treat significant water quantities. The majority of existing water treatment technologies are unable to remove PFAS to the desired extent, are prohibitively expensive or are only useful for a very limited lifespan. This project is expected to develop a new treatment technology with the ability to completely defluorinate PFAS, treat significant water quantities and help address many of the pressing concerns facing water treatment operators. This technology is also scalable, and can potentially be used to treat significant quantities of contaminated water.Read moreRead less
Assessing the impact of habitat restoration on the rates of recovery of four native fish species using advanced statistical models. This project will develop statistical modelling tools to assess how quickly threatened native fish populations recover following habitat restoration. The outcome of this project will aid in understanding the use of habitat restoration in managing endangered stocks of Murray Cod, Trout Cod, Silver Perch and Golden Perch in the Murray River.