Particle Transport and Separation in High Aspect Ratio Inclined Channels. This project will be of benefit to the Australian coal and mineral processing industries, worth tens of billions of dollars to the Australian economy each year. The objective is to establish new options for the processing of particles as large as 50mm, and smaller than 50 microns in size, and hence significantly extend the operating size range of the Reflux Classifier. The development of new resources, especially those of ....Particle Transport and Separation in High Aspect Ratio Inclined Channels. This project will be of benefit to the Australian coal and mineral processing industries, worth tens of billions of dollars to the Australian economy each year. The objective is to establish new options for the processing of particles as large as 50mm, and smaller than 50 microns in size, and hence significantly extend the operating size range of the Reflux Classifier. The development of new resources, especially those of poorer grade, requires more effective separation technology. Success in this project will significantly benefit the end users of the technology and also contribute to Australia's Mining Services industry.Read moreRead less
Self-assembly of gelling biopolymer particles. Biopolymers provide a renewable source of structuring agents for a variety of potential uses in food, pharmaceutical and other applications that require bio-compatibility. Swollen biopolymer particles of sub-millimetre size are particularly useful as they combine macroscopic structure formation with an ability to flow and a desirable soft solid texture. Two limitations to the current utilisation of biopolymer particles are that they either cannot be ....Self-assembly of gelling biopolymer particles. Biopolymers provide a renewable source of structuring agents for a variety of potential uses in food, pharmaceutical and other applications that require bio-compatibility. Swollen biopolymer particles of sub-millimetre size are particularly useful as they combine macroscopic structure formation with an ability to flow and a desirable soft solid texture. Two limitations to the current utilisation of biopolymer particles are that they either cannot be predictably produced direct from a dried form, or if they are (e.g. cooked starch granules), there is a lack of scientific understanding that limits use of natural sources without subsequent chemical modification. This project will provide the science & technology to overcome these limitations.Read moreRead less
Patterned assemblies of molecules on surfaces. Because of their redox and photophysical properties, artificial porphyrin systems have been designed for applications such as light-harvesting antennae, catalysts and sensors. Control of molecular orientation is required in order to construct practical devices, and in this project methods of assembling porphyrins on surfaces in well-defined patterns will be developed. Sophisticated methods will be used to characterise the films produced in these w ....Patterned assemblies of molecules on surfaces. Because of their redox and photophysical properties, artificial porphyrin systems have been designed for applications such as light-harvesting antennae, catalysts and sensors. Control of molecular orientation is required in order to construct practical devices, and in this project methods of assembling porphyrins on surfaces in well-defined patterns will be developed. Sophisticated methods will be used to characterise the films produced in these ways, in order to provide the information necessary to refine procedures and design new molecules suitable for advanced applications. Expected outcomes are new methods and architectures that can ultimately yield devices that act at the molecular level.Read moreRead less
Predictive Assessment Tool for Beach Conditions Using Video Imaging and Neural Network Analysis. Beaches are vital part of Australian lifestyle and economic development. Monitoring of variable beach conditions is vital for beach safety and for management of storm erosion. The aim of this project is to develop an assessment tool which will permit a rating system of beach conditions both from an environmental as well as a leisure aspect. This tool will be developed into a software analysis system ....Predictive Assessment Tool for Beach Conditions Using Video Imaging and Neural Network Analysis. Beaches are vital part of Australian lifestyle and economic development. Monitoring of variable beach conditions is vital for beach safety and for management of storm erosion. The aim of this project is to develop an assessment tool which will permit a rating system of beach conditions both from an environmental as well as a leisure aspect. This tool will be developed into a software analysis system which will include components of artificial intelligence to enable the system to use feedback loops to create a better prediction of the beach morphology relative to the breaking wave characteristics.Read moreRead less
Endosomal Protein Transport: From Molecular Structures to Biological Function. Intracellular transport of biomolecules through the endosomal organelle is critical for normal cellular processes such as signalling, homoeostasis and development. Defects in this fundamental process and subversion of it by bacterial and viral pathogens also lead to many different human diseases. This project will build on Australia's strong programme of structural and cellular biology research to develop key insights ....Endosomal Protein Transport: From Molecular Structures to Biological Function. Intracellular transport of biomolecules through the endosomal organelle is critical for normal cellular processes such as signalling, homoeostasis and development. Defects in this fundamental process and subversion of it by bacterial and viral pathogens also lead to many different human diseases. This project will build on Australia's strong programme of structural and cellular biology research to develop key insights into endosomal trafficking at the molecular level. Outcomes from this work will place Australia at the forefront of international efforts to understand this essential biological process and will have important implications for future design of pharmaceuticals.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347955
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
A Cell Sorter Facility for Neuroscience and Related Biotechnology. Neuroscience is entering an era of accelerated discovery in which Queensland neuroscientists can excel if they gain leadership in key technologies. One critical technology is the ability to obtain specific cell populations from various parts of the nervous system in sufficient quantity and purity to enable their accurate examination by gene array, proteomics and physiological techniques. The aim is to establish the world's first ....A Cell Sorter Facility for Neuroscience and Related Biotechnology. Neuroscience is entering an era of accelerated discovery in which Queensland neuroscientists can excel if they gain leadership in key technologies. One critical technology is the ability to obtain specific cell populations from various parts of the nervous system in sufficient quantity and purity to enable their accurate examination by gene array, proteomics and physiological techniques. The aim is to establish the world's first cell-sorting facility dedicated to the production of nerve cells suitable for molecular characterization and screening, providing the basis for identifying key molecules regulating brain function, ageing and repair of great importance to the biotechnology/pharmaceutical industry.Read moreRead less
Novel approaches for structural and functional analysis of the protein complex COG, a tether that controls intra-Golgi trafficking. Production and engineering of proteins are key methodologies of the life sciences in general and biotechnology in particular. Our ability to produce and analyse protein-based components of the cell determines the expense and speed of discovery, as well as the creation of new vaccines, drugs, and diagnostic methods. The current project aims to develop new approaches ....Novel approaches for structural and functional analysis of the protein complex COG, a tether that controls intra-Golgi trafficking. Production and engineering of proteins are key methodologies of the life sciences in general and biotechnology in particular. Our ability to produce and analyse protein-based components of the cell determines the expense and speed of discovery, as well as the creation of new vaccines, drugs, and diagnostic methods. The current project aims to develop new approaches for protein production and to apply them to the analysis of the basic mechanisms of cell self-maintenance.Read moreRead less
Developing high-flux ceramic membranes via in situ synthesis of metal oxide nanofibres for separations of biological substances. This project can deliver advanced technology for fabricating ceramic membranes and biological separation, which has considerable commercial prospects in the chemical, pharmaceutical, dairy, food and water industries. The new ceramic membrane and nanofibres are highly-valued end products of metal oxides, which are manufactured commercially on large scale in Australia. T ....Developing high-flux ceramic membranes via in situ synthesis of metal oxide nanofibres for separations of biological substances. This project can deliver advanced technology for fabricating ceramic membranes and biological separation, which has considerable commercial prospects in the chemical, pharmaceutical, dairy, food and water industries. The new ceramic membrane and nanofibres are highly-valued end products of metal oxides, which are manufactured commercially on large scale in Australia. The project could bring direct benefits to the existing industries, by fostering their growth into more value-added processes, and exporting highly-valued products abroad. Additionally, efficient ceramic membranes could offer solutions to the large-scale purification of biological substances and to the problems for providing clean drinking water.Read moreRead less
The molecular mechanism of retromer and sorting nexin function in endosomal membrane trafficking. The proposed research represents breakthrough science that will lead to a fundamental understanding at the molecular level of the structure and assembly of the retromer complex and how it regulates sorting of receptors in the endosomal system. It will provide excellent research training for top graduate students and post-doctoral scientists in multidisciplinary methods that constitute state-of the- ....The molecular mechanism of retromer and sorting nexin function in endosomal membrane trafficking. The proposed research represents breakthrough science that will lead to a fundamental understanding at the molecular level of the structure and assembly of the retromer complex and how it regulates sorting of receptors in the endosomal system. It will provide excellent research training for top graduate students and post-doctoral scientists in multidisciplinary methods that constitute state-of the-art structural and molecular cell biology research. By addressing an area of great interest internationally the project will have the capacity to increase Australia's knowledge base and strengthen it's reputation for research excellence.Read moreRead less
Formally-Based Security Evaluation Procedures. Guaranteeing information security is of critical national importance, especially in the current political climate. Devices intended to safeguard Australia's electronic communications must be proven secure using leading-edge techniques. Currently, evaluation of such devices relies on informal procedures and the experience of individuals. This project will introduce more rigour into security evaluations by adapting techniques from the fields of saf ....Formally-Based Security Evaluation Procedures. Guaranteeing information security is of critical national importance, especially in the current political climate. Devices intended to safeguard Australia's electronic communications must be proven secure using leading-edge techniques. Currently, evaluation of such devices relies on informal procedures and the experience of individuals. This project will introduce more rigour into security evaluations by adapting techniques from the fields of safety analysis and formal methods. In particular, mathematical concepts will be introduced using notations suitable for use by security personnel with no prior formal methods experience. The outcomes of this project will enable more efficient and effective information security evaluations.Read moreRead less