A proteomic approach to identifying the signaling pathway(s) by which acute oxidative stress causes cell death by apoptosis. Oxidative stress following traumatic injury (heart attack or stroke) is known to activate signaling pathways leading to programmed cell death (apoptosis). The aim of this project is to develop methods to identify the signaling proteins involved. Identifying proteins involved in causing cell death will be useful in developing diagnostic tools as well as providing potential ....A proteomic approach to identifying the signaling pathway(s) by which acute oxidative stress causes cell death by apoptosis. Oxidative stress following traumatic injury (heart attack or stroke) is known to activate signaling pathways leading to programmed cell death (apoptosis). The aim of this project is to develop methods to identify the signaling proteins involved. Identifying proteins involved in causing cell death will be useful in developing diagnostic tools as well as providing potential therapeutic possibilities.Read moreRead less
Feeding and digestion in tropical rock lobster phyllosoma larvae and its applications for culture. Provision of larval culture diets that provide optimal nutrition in a suitable presentation format is the major challenge for developing a rock lobster aquaculture industry. Tropical rock lobsters are likely contenders due to their faster growth rates and shorter larval phase than temperate species. This project will assess the ingestive and digestive capabilities of larvae during development, thro ....Feeding and digestion in tropical rock lobster phyllosoma larvae and its applications for culture. Provision of larval culture diets that provide optimal nutrition in a suitable presentation format is the major challenge for developing a rock lobster aquaculture industry. Tropical rock lobsters are likely contenders due to their faster growth rates and shorter larval phase than temperate species. This project will assess the ingestive and digestive capabilities of larvae during development, through an examination of mouthpart and gut structure and their types and concentration of digestive enzymes. Information will be used to formulate and test improved diets of appropriate size, texture and nutritional composition and will be the first comprehensive analysis of preferred larval diets on the basis of their biological and physiological characteristics.Read moreRead less
Proteome mapping of the model fungal plant pathogen Stagonospora nodorum using LC-LC-MS/MS. Stagonospora nodorum is a fungus that causes leaf and glume blotch disease on wheat. This disease alone causes $55 million dollars in yield losses per annum in Australia. This project aims to identify the proteins produced by Stagonospora nodorum through the development of a new proteomics technique. Two clear benefits to the community resulting from this project will emerge. The first will be the expert ....Proteome mapping of the model fungal plant pathogen Stagonospora nodorum using LC-LC-MS/MS. Stagonospora nodorum is a fungus that causes leaf and glume blotch disease on wheat. This disease alone causes $55 million dollars in yield losses per annum in Australia. This project aims to identify the proteins produced by Stagonospora nodorum through the development of a new proteomics technique. Two clear benefits to the community resulting from this project will emerge. The first will be the expert training of a student in proteomics, a skill that is keenly sought. Secondly, the identification of these pathogen proteins will lead to new strategies to better control the disease and secure the supply of wheat.Read moreRead less
Accelerating the genetic improvement of grain legumes for Australia by developing doubled haploid technology for field pea and chickpea. Doubled haploid technology is used in many broad acre crop species to accelerate cultivar development and create homozygous populations for genetic mapping. Field pea and chickpea have been unresponsive to this technique but a recent breakthrough by UWA researchers has resulted in haploid pro-embryos from in vitro cultured immature pollen. A barrier to further ....Accelerating the genetic improvement of grain legumes for Australia by developing doubled haploid technology for field pea and chickpea. Doubled haploid technology is used in many broad acre crop species to accelerate cultivar development and create homozygous populations for genetic mapping. Field pea and chickpea have been unresponsive to this technique but a recent breakthrough by UWA researchers has resulted in haploid pro-embryos from in vitro cultured immature pollen. A barrier to further embryo maturation has been identified, which we propose to overcome using powerful microscopy tools to elucidate haploid embryology processes. This information will be applied to develop world-first in vitro doubled haploid protocols for these species, which will facilitate the development and accelerated delivery to industry of better adapted, high yielding cultivars.Read moreRead less
A hand up: Disrupting the communication of intergenerational welfare dependency. Some families rely permanently on welfare support and communicate this dependency to the next generation. Children growing up in these families find it difficult to break out of poverty. With the help of twelve families and members of the St Vincent de Paul Society (Western Australia), this project aims to create ethnographies which illuminate turning points and opportunities for change. It will look to use creative ....A hand up: Disrupting the communication of intergenerational welfare dependency. Some families rely permanently on welfare support and communicate this dependency to the next generation. Children growing up in these families find it difficult to break out of poverty. With the help of twelve families and members of the St Vincent de Paul Society (Western Australia), this project aims to create ethnographies which illuminate turning points and opportunities for change. It will look to use creative and educational interventions to explore new ways of delivering services and disrupting the communication of welfare dependency. Ending inherited poverty is a significant step in helping individuals reach their potential and frees resources for people facing sudden hardship.Read moreRead less
Physiology and genetics of barley grain germination in the malting and brewing industries. An international research team will provide new scientific information on barley grain germination. This detailed basic knowledge will be immediately applied in breeding programs that are aimed at improving malting and brewing quality in a commercial context. At the same time, the industry's carbon footprint will be significantly reduced.
An ethnographic investigation into the everyday work and communication cultures of public transport transit guards: reducing risk and injury. This research improves the safety of public transport for workers and passengers with flow-on benefits at local and national levels. The main health and safety risk transit guards face is attacks upon them, or injury incurred while intervening in assaults they witness. Conventional initiatives have not impacted greatly on injury rates but culture and commu ....An ethnographic investigation into the everyday work and communication cultures of public transport transit guards: reducing risk and injury. This research improves the safety of public transport for workers and passengers with flow-on benefits at local and national levels. The main health and safety risk transit guards face is attacks upon them, or injury incurred while intervening in assaults they witness. Conventional initiatives have not impacted greatly on injury rates but culture and communication change strategies offer potential ways forward. Strategies that reduce incidents confer clear community benefits and competitive advantage. Effective management of such challenges assists with the recruitment and retention of appropriate staff, improving profitability. Benefits include reduced costs of public transport, increased passenger load, and positive environmental impacts.Read moreRead less
Young People, Technology, and Wellbeing Research Facility. Large numbers of initiatives now mobilise technology to support the wellbeing of young Australians. However, amongst communities undertaking this work, there is currently significant duplication and insufficient sharing of research and best practice models. A Research Facility that consolidates existing research, and guides new research and initiatives will improve service delivery to young Australians by: reducing duplication between or ....Young People, Technology, and Wellbeing Research Facility. Large numbers of initiatives now mobilise technology to support the wellbeing of young Australians. However, amongst communities undertaking this work, there is currently significant duplication and insufficient sharing of research and best practice models. A Research Facility that consolidates existing research, and guides new research and initiatives will improve service delivery to young Australians by: reducing duplication between organizations working with young people; providing an accessible interface with research that can help address the community’s concerns about the role of technology in young people’s lives, and inform future policy and programs; and model effective cross-sector knowledge brokering to Australian industry. Read moreRead less
Detection and elimination of resting spores of Olpidium vectoring lettuce big-vein disease in lettuce seedling nursery production. This project will devise nucleic acid and serology methods for detection of Olpidium brassicae, vector of lettuce big-vein disease (LBVD), during various phases of lettuce seedling production in nursery environments. It will be the first study to develop sustainable and environmentally responsible nursery best-practice protocols for integrated management of O. brass ....Detection and elimination of resting spores of Olpidium vectoring lettuce big-vein disease in lettuce seedling nursery production. This project will devise nucleic acid and serology methods for detection of Olpidium brassicae, vector of lettuce big-vein disease (LBVD), during various phases of lettuce seedling production in nursery environments. It will be the first study to develop sustainable and environmentally responsible nursery best-practice protocols for integrated management of O. brassicae in routine seedling production and for management within the lettuce industry. These protocols will ensure that the spread of LBVD from contaminated lettuce nurseries to farms is prevented. It will also be a unique study of the establishment of a disease in new land with different soils and agricultural practices.Read moreRead less
Digital storytelling and co-creative media: the role of community arts and media in propagating and coordinating population-wide creative practice. Community arts, community broadcasting and Indigenous media producers all face the challenge of digital media and user-led innovation. This project brings these systems together to test how existing infrastructure and new media affordances can be combined to stimulate broad-based innovation through creative participation.