Future Industries Research - Biotechnology and Nanotechnology: Small talk: Communication networks in microbes. We will use the Australian Proteome Analysis Facility to address the multifaceted mechanisms of microbial interactions and produce new knowledge about the pathogen Pseudomonas aeruginosa, a common cause of death in cystic fibrosis patients. We will characterise the interactions between P. aeruginosa and the emerging fungal pathogen Scedosporium aurantiacum as a proactive step towards be ....Future Industries Research - Biotechnology and Nanotechnology: Small talk: Communication networks in microbes. We will use the Australian Proteome Analysis Facility to address the multifaceted mechanisms of microbial interactions and produce new knowledge about the pathogen Pseudomonas aeruginosa, a common cause of death in cystic fibrosis patients. We will characterise the interactions between P. aeruginosa and the emerging fungal pathogen Scedosporium aurantiacum as a proactive step towards better understanding of pathogen communication. Improved understanding of pathogen interactions should facilitate the development of novel anti-adhesives as therapeutics. Our project will train young scientists in a new integrated approach to biology.Read moreRead less
Three dimensional polymer structures for bionic applications. The polymer based three dimensional (3D) structures targeted for production in this project will bring unique capabilities to the field of bionics research. A multi-modal 3D scaffold capable of delivering biofactors, supporting cell growth and providing power for stimulation will significantly advance the efforts being made in bionic research. This will have profound effects on the quality of life for those suffering from a range of m ....Three dimensional polymer structures for bionic applications. The polymer based three dimensional (3D) structures targeted for production in this project will bring unique capabilities to the field of bionics research. A multi-modal 3D scaffold capable of delivering biofactors, supporting cell growth and providing power for stimulation will significantly advance the efforts being made in bionic research. This will have profound effects on the quality of life for those suffering from a range of medical conditions, from spinal cord injury through to epilepsy. Here we will demonstrate the capabilities of these novel polymer structures both in-vitro and in-vivo.Read moreRead less
Disruptive approaches to biological sensing. Optical fibre-based biosensors have the potential to transform our ability to monitor our environment, protect our nation's assets and safeguard our citizens, and to offer improved clinical diagnostics and food quality control by creating tools that can detect biomolecules in real-time within complex samples. To fulfil this mission, we propose to develop new fibre-based sensing architectures for sensing biomolecules that have the potential to be sensi ....Disruptive approaches to biological sensing. Optical fibre-based biosensors have the potential to transform our ability to monitor our environment, protect our nation's assets and safeguard our citizens, and to offer improved clinical diagnostics and food quality control by creating tools that can detect biomolecules in real-time within complex samples. To fulfil this mission, we propose to develop new fibre-based sensing architectures for sensing biomolecules that have the potential to be sensitive, selective, fast and compact.Read moreRead less
Nanoengineered Polymeric Materials for Environmental and Biological Applications. The development of advanced materials with nanoengineered properties promises to revolutionise future industries, including the energy and healthcare sectors. This research program will involve the design, synthesis and assembly of tailored polymers to prepare next-generation, engineered materials. The research will deliver advanced polymeric membranes, tissue engineering scaffolds and vaccine delivery systems. The ....Nanoengineered Polymeric Materials for Environmental and Biological Applications. The development of advanced materials with nanoengineered properties promises to revolutionise future industries, including the energy and healthcare sectors. This research program will involve the design, synthesis and assembly of tailored polymers to prepare next-generation, engineered materials. The research will deliver advanced polymeric membranes, tissue engineering scaffolds and vaccine delivery systems. These materials are expected to provide benefits for Australian citizens in the energy and health sectors and contribute to the development of a robust Australian nanotechnology industry. The projects will also provide opportunities for the development of outstanding young scientists and will foster multidisciplinary collaborations.Read moreRead less
Developing biotechnology solutions for improving phosphate acquisition in plants using functional genomics in rice. Global supplies of the most currently used phosphate fertilisers are predicted to be exhausted in less than a century. These fertilisers are non-renewable resources based on phosphate rock deposits and their use are key drivers of both plant production costs and environmental damage in Australia and internationally. Using the power of genetic and functional genomics analyses in ric ....Developing biotechnology solutions for improving phosphate acquisition in plants using functional genomics in rice. Global supplies of the most currently used phosphate fertilisers are predicted to be exhausted in less than a century. These fertilisers are non-renewable resources based on phosphate rock deposits and their use are key drivers of both plant production costs and environmental damage in Australia and internationally. Using the power of genetic and functional genomics analyses in rice, this project will reveal key controllers of phosphate acquisition in plants. Hence, novel biotechnology based solutions can be implemented in a variety of cereal crops to aid reduced use of phosphate fertiliser in agriculture and unlock the large phosphate pool not used by plants in soil.Read moreRead less
Extreme expression: building a platform for industrial plant biotechnology. Plants have remarkable potential as bioreactors for the production of usually non-plant compounds such as medical proteins, industrial proteins including enzymes and polymers. However, to realise this potential, there needs to be very significant advances in the amount of target compounds produced in the bioreactor plants and to develop other plant species as bioreactors. The aim of this project is to develop technologie ....Extreme expression: building a platform for industrial plant biotechnology. Plants have remarkable potential as bioreactors for the production of usually non-plant compounds such as medical proteins, industrial proteins including enzymes and polymers. However, to realise this potential, there needs to be very significant advances in the amount of target compounds produced in the bioreactor plants and to develop other plant species as bioreactors. The aim of this project is to develop technologies that provide the platform to produce large quantities of target novel compounds in plants and extend the range of plant species that can be used as bioreactors. These technologies will provide the basis of a dynamic biofarming industry in Australia.Read moreRead less