Manipulation of Nano-Scale Assembly, Structure and Interaction: New Drug Delivery Vehicles and Energy Storage Devices for Miniaturised Portable Electronic Products. Nano-scale molecular and surface interactions will be manipulated to develop new nano-structured products. There will be two themes of research activity. In the first theme, newly discovered ionic liquids will be employed to better elucidate the role of hydrophobic interaction in molecular assembly processes. These findings wil ....Manipulation of Nano-Scale Assembly, Structure and Interaction: New Drug Delivery Vehicles and Energy Storage Devices for Miniaturised Portable Electronic Products. Nano-scale molecular and surface interactions will be manipulated to develop new nano-structured products. There will be two themes of research activity. In the first theme, newly discovered ionic liquids will be employed to better elucidate the role of hydrophobic interaction in molecular assembly processes. These findings will assist in the development of surfactant-drug conjugates that can self-assemble and can converge therapeutic, drug delivery and controlled release functions; allowing drugs to be administered in the therapeutic concentration range for prolonged periods of time with reduced side-effects. In the second theme, nano-materials will be used to converge capacitor and battery technologies to provide a dramatic performance boost to miniaturised portable electronic devices.Read moreRead less
New Methods for Structural Biology in Solution. It is proposed to establish a new research group that focuses on the development of new nuclear magnetic resonance (NMR) technologies and applications to problems concerning protein structure and function. This includes
- the exploitation of new NMR parameters;
- optimization of an inexpensive in vitro protein expression system;
- development of experimental strategies for the identification of protein-ligand surfaces by chemical modificatio ....New Methods for Structural Biology in Solution. It is proposed to establish a new research group that focuses on the development of new nuclear magnetic resonance (NMR) technologies and applications to problems concerning protein structure and function. This includes
- the exploitation of new NMR parameters;
- optimization of an inexpensive in vitro protein expression system;
- development of experimental strategies for the identification of protein-ligand surfaces by chemical modification, as a basis for high-throughput mass spectrometrical analyses;
- development of an algorithm for rapid resonance assignment of 15N-labelled proteins which is of importance for the pharmaceutical industry;
- 3D structure determinations of proteins and protein domains.Read moreRead less
How organisms coordinate energy supply and demand. The metabolic stress sensing protein kinase called the AMP activated protein kinase controls metabolism of all eukaryotes to meet the needs of energy demand and nutrient supply. It is responsible for accelerating metabolism (glucose transport, glycolysis and fatty acid oxidation) in response to energy demand and with caloric restriction it regulates gene transcription to adapt to energy supply. This project is to provide a comprehensive unders ....How organisms coordinate energy supply and demand. The metabolic stress sensing protein kinase called the AMP activated protein kinase controls metabolism of all eukaryotes to meet the needs of energy demand and nutrient supply. It is responsible for accelerating metabolism (glucose transport, glycolysis and fatty acid oxidation) in response to energy demand and with caloric restriction it regulates gene transcription to adapt to energy supply. This project is to provide a comprehensive understanding of the AMP activated protein kinase (enzyme isoforms, genes, physiological roles and regulation). This knowledge will have major benefits in biopharmaceutical development, the livestock, plant and sport/racing industries.Read moreRead less