Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100090
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
Surface and Colloid Characterisation Facility. Surface and colloid characterisation facility: Surface science lies at the heart of biointerface and colloid science. This facility will enable particle size, shape, distribution, surface area and charge to be measured as well as the amount of material adsorbed to interfaces, the configuration of that material and the response of the surface to stimuli such as changing pH or salinity. All these parameters influence the properties of these important ....Surface and Colloid Characterisation Facility. Surface and colloid characterisation facility: Surface science lies at the heart of biointerface and colloid science. This facility will enable particle size, shape, distribution, surface area and charge to be measured as well as the amount of material adsorbed to interfaces, the configuration of that material and the response of the surface to stimuli such as changing pH or salinity. All these parameters influence the properties of these important systems. As such this facility will underpin the research of a number of groups across three institutions over the next decade and promote collaboration between scientists with a range of complementary expertise in fields where surface science is important from biology to ionic liquids.Read moreRead less
Next-generation polymer films for control of material interactions. This project will develop smart polymer films which incorporate a mechanism which rapidly switches the coating from being attracted to or repelled by adjacent material. These films will be made using a new water-based technology and assessed for potential application such as: (1) active agents for mineral processing, or (2) high performance lubricants.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100234
Funder
Australian Research Council
Funding Amount
$155,000.00
Summary
Facility for Nanometer Scale Microscopy, Characterization, and Fabrication. Facility for nanometre-scale microscopy, characterisation, and fabrication:
This project aims to create a collaborative research facility for the microscopy and characterisation of nanometre structured devices and materials, enabling researchers to visualise and quantify the topography, chemical composition and structure of samples with a resolution approaching the atomic scale. A WiTek Alpha300SR microscope is capable ....Facility for Nanometer Scale Microscopy, Characterization, and Fabrication. Facility for nanometre-scale microscopy, characterisation, and fabrication:
This project aims to create a collaborative research facility for the microscopy and characterisation of nanometre structured devices and materials, enabling researchers to visualise and quantify the topography, chemical composition and structure of samples with a resolution approaching the atomic scale. A WiTek Alpha300SR microscope is capable of simultaneous atomic force microscopy, near-field scanning optical microscopy, photocurrent mapping, and Raman spectroscopy. These capabilities would allow the mapping of topography and chemical composition, response to optical stimulus, and the structure of materials in 3-D with nanometre-scale resolution on surfaces. This instrument would support research in areas such as organic photovoltaics, nanofabrication, polymer electronics, ionic fluids, functional interfaces, and thermionic devices.Read moreRead less
Understanding platinum dissolution in biomedical stimulating electrodes. Platinum is the main material used in electrodes for neurostimulators like the cochlear implant. Platinum electrodes can experience dissolution during implantation, which can impact on their function. The mechanisms governing this dissolution process are complex and still not fully understood. This research aims to understand the chemical, electrical and biological factors that impact on platinum dissolution in electrodes. ....Understanding platinum dissolution in biomedical stimulating electrodes. Platinum is the main material used in electrodes for neurostimulators like the cochlear implant. Platinum electrodes can experience dissolution during implantation, which can impact on their function. The mechanisms governing this dissolution process are complex and still not fully understood. This research aims to understand the chemical, electrical and biological factors that impact on platinum dissolution in electrodes. It will also develop new 3D models to simulate conditions in the human body for more rapid testing of electrodes. The new knowledge generated will improve the accuracy of predictions of platinum dissolution, develop new approaches for minimising dissolution, and contribute to reducing need for animal experimentation.Read moreRead less
Programming anisotropy into responsive soft materials. The project aims to generate viscoelastic soft materials with programmable anisotropy using aqueous suspensions of colloidal rods that have tunable surface coatings. The project expects to generate new knowledge in the rheology and structural characteristics of this unique class of materials. A key innovation is the use of charge-directed polymer self-assembly to control colloidal interactions, suspension rheology and phase behaviour. The in ....Programming anisotropy into responsive soft materials. The project aims to generate viscoelastic soft materials with programmable anisotropy using aqueous suspensions of colloidal rods that have tunable surface coatings. The project expects to generate new knowledge in the rheology and structural characteristics of this unique class of materials. A key innovation is the use of charge-directed polymer self-assembly to control colloidal interactions, suspension rheology and phase behaviour. The intended outcome is spatial control over the orientation of nanostructures, potentially mimicking the structural hierarchy found in nature. This should provide significant benefits to the creation of viscoelastic materials with complex rheology as well as structural, mechanical and optical heterogeneity.Read moreRead less
Tuning Molecular Translocaton by Close-Field Electroporation. This project aims to determine the underlying mechanisms by which DNA and other molecules are able to migrate across the cell membrane in response to highly localised electric fields. It has recently been shown that focusing of electric fields at the cellular level, using an array of small electrodes, results in unexpectedly high cell transfection efficiencies. It has been termed 'close-field electroporation'. Here it is proposed t ....Tuning Molecular Translocaton by Close-Field Electroporation. This project aims to determine the underlying mechanisms by which DNA and other molecules are able to migrate across the cell membrane in response to highly localised electric fields. It has recently been shown that focusing of electric fields at the cellular level, using an array of small electrodes, results in unexpectedly high cell transfection efficiencies. It has been termed 'close-field electroporation'. Here it is proposed to establish the properties of the electric fields around cells and cell membrane interactions with these fields that enable molecular translocation. This fundamental science could have broad implications in the domains of drug delivery, gene therapy and neural stimulation.Read moreRead less
Multiscale physics for enhanced oil recovery. The project aims to develop a multiscale mathematical and laboratory modelling methodology for combined enhanced oil recovery (EOR) and CO2 storage, and synthesise the technology for Santos’s Mulberry oilfield as a test case. The multidisciplinary team will develop advanced reservoir- and laboratory-scale mathematical models and novel laboratory methods to enhance the reliability of modern EOR and CO2 storage and increase its uptake by companies in A ....Multiscale physics for enhanced oil recovery. The project aims to develop a multiscale mathematical and laboratory modelling methodology for combined enhanced oil recovery (EOR) and CO2 storage, and synthesise the technology for Santos’s Mulberry oilfield as a test case. The multidisciplinary team will develop advanced reservoir- and laboratory-scale mathematical models and novel laboratory methods to enhance the reliability of modern EOR and CO2 storage and increase its uptake by companies in Australia and globally. The expected outcomes are a pioneering methodology with environmental benefits without additional drilling and reduction of greenhouse effect, and economic benefit to the Australian oil industry through increases in productivity.Read moreRead less
A new strategy for design flood estimation in a nonstationary climate. Evidence suggests that global warming will result in an increase in the frequency and/or magnitude of heavy rainfall, leading to flooding with potentially devastating consequences. This study provides a renewed focus on design flood estimation that takes into account a changing climate where assumptions of stationarity are no longer tenable.
A thermodynamic pathway to intracellular delivery. Cells transmit information through molecules. By delivering foreign molecules into cells, such as DNA and proteins, it is possible to engineer and reprogram cells just like a computer. This proposal aims to develop a novel microfluidic device for intracellular delivery. The device will work by exposing cells to rapid thermal shock to generate transient disruptions in cell membranes and thereby enable influx of foreign molecules into cells. To un ....A thermodynamic pathway to intracellular delivery. Cells transmit information through molecules. By delivering foreign molecules into cells, such as DNA and proteins, it is possible to engineer and reprogram cells just like a computer. This proposal aims to develop a novel microfluidic device for intracellular delivery. The device will work by exposing cells to rapid thermal shock to generate transient disruptions in cell membranes and thereby enable influx of foreign molecules into cells. To understand how the method can be optimized, the thermodynamic pathway of membrane disruption will be investigated at a single cell level. The methods and insights arising from this project could eventually lead to novel, patentable and lower-cost health technologies.Read moreRead less
Electric field effects on cochlear tissues. The project aims to solve the underlying biology of how electricity flows through the cochlear tissues, where and how electrical stimulation excites the auditory neurons, and what the effects of sustained electrical stimulation are on the nerve fibre growth and function. The research aims to show how electric fields can be controlled in the cochlea, and how auditory nerve fibres are affected at the cellular and molecular level. The long-term aim is to ....Electric field effects on cochlear tissues. The project aims to solve the underlying biology of how electricity flows through the cochlear tissues, where and how electrical stimulation excites the auditory neurons, and what the effects of sustained electrical stimulation are on the nerve fibre growth and function. The research aims to show how electric fields can be controlled in the cochlea, and how auditory nerve fibres are affected at the cellular and molecular level. The long-term aim is to utilise these findings to improve the control of neuronal excitability, for development of interfaces with the nervous system.Read moreRead less