Extreme soil acidification and metal release risks from increasing drought. The project aims to study the effects of drought on pH and metal speciation in soils, and develop tools to assess current and future risks. Social and economic well-being depends on good soil and water quality. Climate change makes droughts more frequent and severe, which could cause soil acidification (pH<4) and metal release in many regions. The project will integrate experimental data on the effects of drought on soil ....Extreme soil acidification and metal release risks from increasing drought. The project aims to study the effects of drought on pH and metal speciation in soils, and develop tools to assess current and future risks. Social and economic well-being depends on good soil and water quality. Climate change makes droughts more frequent and severe, which could cause soil acidification (pH<4) and metal release in many regions. The project will integrate experimental data on the effects of drought on soil geochemistry with hydro-geochemical models, and apply these to national-scale predictions. The intended outcomes are improved management and preparedness for droughts and new research directions for geochemistry.Read moreRead less
Patchy colloidosomes at interfaces: correlation of particle surface heterogeneity, wettability, and chemical activity at the nanoscale. The surfaces of natural mineral particles are made up of spots with such different chemical and physical properties. The complexity makes it hard to predict their behaviour. This project will provide insights into how the 'patchy' nature of particle surfaces affects their behaviour in processes such as flotation separation and bio-fuel production.
Closing the data gap: High throughput screening of nanoparticle toxicity. The nanotechnology sector is experiencing an exponential growth period with over 100 products containing manufactured nanoparticles entering the market every year. Ensuring growth of the sector needs to be balanced against the imperative of protecting both human and environmental safety. This project aims to develop new methodological and conceptual avenues to close the gap between innovation in nanotechnology and risk ass ....Closing the data gap: High throughput screening of nanoparticle toxicity. The nanotechnology sector is experiencing an exponential growth period with over 100 products containing manufactured nanoparticles entering the market every year. Ensuring growth of the sector needs to be balanced against the imperative of protecting both human and environmental safety. This project aims to develop new methodological and conceptual avenues to close the gap between innovation in nanotechnology and risk assessment. This is intended to be achieved by developing and validating high-throughput in vitro toxicity screening platforms for manufactured nanoparticles. The approach is based on advanced lab-on-a-chip microfluidic technologies. The predictive power of the platform will be refined and optimised via ex-vivo and in-vivo models.Read moreRead less
Climate and environmental history of SE Queensland dunefields. This project aims to generate fundamental information about the timing and mode of formation of sand dunes in the world's largest downdrift sand system, Cooloola and Fraser Island, Queensland. The project aims to provide a world class record of climate variability, sea-level change and long term climate change from the sub-tropics of Australia, an area critical to understanding global climate links and sea-level change but where high ....Climate and environmental history of SE Queensland dunefields. This project aims to generate fundamental information about the timing and mode of formation of sand dunes in the world's largest downdrift sand system, Cooloola and Fraser Island, Queensland. The project aims to provide a world class record of climate variability, sea-level change and long term climate change from the sub-tropics of Australia, an area critical to understanding global climate links and sea-level change but where high quality long-term records are sparse and little investigated. This project will also underpin the outstanding universal value of the Fraser Island World Heritage Area which is based on the area being the world's largest sand island, but for which scientific understanding of the sand dunes is remarkably poor.Read moreRead less
Unravelling the principles of bilateral brain wiring. This project seeks to investigate the molecular principles of brain wiring in mammals and how small changes can generate complex outcomes. Neurons in the mammalian brain must be precisely wired together for the brain to function correctly. The project aims to identify the molecular and cellular rules governing commissural wiring in the mammalian cortex to determine how the largest fibre tract in the human brain, the corpus callosum, evolved. ....Unravelling the principles of bilateral brain wiring. This project seeks to investigate the molecular principles of brain wiring in mammals and how small changes can generate complex outcomes. Neurons in the mammalian brain must be precisely wired together for the brain to function correctly. The project aims to identify the molecular and cellular rules governing commissural wiring in the mammalian cortex to determine how the largest fibre tract in the human brain, the corpus callosum, evolved. This may have involved modifications in mechanisms affecting axon guidance that differ between placentals and marsupials. The project investigates the regulatory gene networks determining commissural neuron fate, the regulation of axon guidance components, and the influence of surrounding brain tissue on the development of commissural connections.Read moreRead less
Protecting cereal grain development at high temperatures. This project aims to investigate new temperature-responsive factors that regulate cereal grain development to protect grain production under heat stress. The new research will leverage international collaborations with access to cutting-edge genetic and technological resources, and refine novel X-ray imaging techniques in Australia, to observe how temperature affects flower structure and function in barley and rice. Favourable mutations t ....Protecting cereal grain development at high temperatures. This project aims to investigate new temperature-responsive factors that regulate cereal grain development to protect grain production under heat stress. The new research will leverage international collaborations with access to cutting-edge genetic and technological resources, and refine novel X-ray imaging techniques in Australia, to observe how temperature affects flower structure and function in barley and rice. Favourable mutations that optimise plant yield and fitness will be defined and explored in other, more complex, cereals such as wheat. Expected outcomes will be fundamental breakthroughs in understanding how plants respond to, and buffer, the effects of heat to lead to translational breeding strategies that bolster grain yield.Read moreRead less
Safer gene editing tools for Australian livestock and biotech industries. Editing the genome of an organism in an efficient and safe fashion is critical for the livestock and biotechnology industries. While CRISPR-Cas9 has become the method of choice for genome editing, it is known to introduce unwanted "on-target" and "off-target" mutations, limiting its utility. To address this the CI team created a novel genome editing platform technology termed Crackling-CAST that is almost 100% accurate, w ....Safer gene editing tools for Australian livestock and biotech industries. Editing the genome of an organism in an efficient and safe fashion is critical for the livestock and biotechnology industries. While CRISPR-Cas9 has become the method of choice for genome editing, it is known to introduce unwanted "on-target" and "off-target" mutations, limiting its utility. To address this the CI team created a novel genome editing platform technology termed Crackling-CAST that is almost 100% accurate, while retaining the efficiency of the classical Cas9 system. This project will exemplify the capabilities of the novel gene targeting platform in cell types used by the biotechnology and livestock sectors, ensuring its global uptake by these industries and delivering significant economic benefits for Australia. Read moreRead less