A novel modelling approach for understanding wildlife disease dynamics. This project aims to develop a novel framework for field wildlife disease systems, applied to chytrid fungal infection of an endangered frog species as a case study. The project expects to develop models able to be applied to many disease systems, improve understanding of host resistance and tolerance to infection, and improve capacity for mitigation of emerging infectious diseases. This work should have international impac ....A novel modelling approach for understanding wildlife disease dynamics. This project aims to develop a novel framework for field wildlife disease systems, applied to chytrid fungal infection of an endangered frog species as a case study. The project expects to develop models able to be applied to many disease systems, improve understanding of host resistance and tolerance to infection, and improve capacity for mitigation of emerging infectious diseases. This work should have international impact and provide significant national benefits in ensuring the conservation of Australia’s biodiversity.Read moreRead less
Cause and effect: new mechanisms of particles formation in thunderstorms. This project aims to identify meaningful and specific indicators for predicting particle formation and alteration during thunderstorms. How thunderstorms develop is well-understood. However, identifying meaningful and specific indicators for predicting particle alteration during a thunderstorm is still not clear. This project will practically contribute to the evidence of the impact of air particulates, thereby having dire ....Cause and effect: new mechanisms of particles formation in thunderstorms. This project aims to identify meaningful and specific indicators for predicting particle formation and alteration during thunderstorms. How thunderstorms develop is well-understood. However, identifying meaningful and specific indicators for predicting particle alteration during a thunderstorm is still not clear. This project will practically contribute to the evidence of the impact of air particulates, thereby having direct implications for meteorological, and air pollution policy in Australia and worldwide. This project will allow researchers to understand the impact of these factors on the escalation of the causative effects, and to find a way to prevent unnecessary fatal outcomes.Read moreRead less
Composite Mesoporous Solids of TiO2 Nano-Crystals and Silicate as Photo-catalysts for Degradation of Organic Contaminants in Water. TiO2 photo-catalysis is a promising advanced technique for breaking down organic contaminants and bacteria in water and air. This project will develop a novel class of photo-catalysts, the composite meosporous compounds of anatase and layered clay, by combining templated synthesis and pillaring techniques. They will exhibit a high photo-catalytic efficiency with sup ....Composite Mesoporous Solids of TiO2 Nano-Crystals and Silicate as Photo-catalysts for Degradation of Organic Contaminants in Water. TiO2 photo-catalysis is a promising advanced technique for breaking down organic contaminants and bacteria in water and air. This project will develop a novel class of photo-catalysts, the composite meosporous compounds of anatase and layered clay, by combining templated synthesis and pillaring techniques. They will exhibit a high photo-catalytic efficiency with superior properties for practical operations because of the framework of large porosity arising from the arrangement of discrete anatase nano-particles within the silicate layers. The project involves mostly fundamental research into material synthesis, colloid and surface chemistry and photo-catalysis, and aims to develop advanced techniques for water treatment.Read moreRead less
Understanding the potency and role of individual stem cells in the skin using Rainbow technology. To renew itself, the skin and its components rely on the activity of stem cells. This project will define more precisely the role of each individual stem cell by labelling them with a unique colour and following its fate. This project has the potential to change our current view on how the skin maintains and repairs itself.
Migration-Dependent Signalling in Macrophages . The project aims to investigate a mechanism of communication used by immune cells to guide each other towards sites of damage. The project will characterise newly revealed cell signalling membrane trails left behind by migrating cells, utilising biochemistry, innovative imaging and microscopy and a transparent zebrafish model to view cell migration through living tissues. Expected outcomes include new fundamental knowledge in the area of immune cel ....Migration-Dependent Signalling in Macrophages . The project aims to investigate a mechanism of communication used by immune cells to guide each other towards sites of damage. The project will characterise newly revealed cell signalling membrane trails left behind by migrating cells, utilising biochemistry, innovative imaging and microscopy and a transparent zebrafish model to view cell migration through living tissues. Expected outcomes include new fundamental knowledge in the area of immune cell migration with relevance to the basic biology of inflammation, repair and regeneration and new innovations for cell imaging. Significant benefits are expected to arise from this new knowledge and from advanced skills training and improved national capabilities in bio-imaging and analysis.Read moreRead less
Reactions of Nanoparticles of Metal Oxides and Hydrous Oxides and their Applications in Photocatalysts and Electrode Materials. Australia is a world-leading producer of raw materials of many metallic elements, most of which are exported at low-values. This project will yield important knowledge in new synthetic techniques for making nanostructures of metal oxides. These tiny particles already have a large worldwide market, but the discovery of particles with superior properties or new applicatio ....Reactions of Nanoparticles of Metal Oxides and Hydrous Oxides and their Applications in Photocatalysts and Electrode Materials. Australia is a world-leading producer of raw materials of many metallic elements, most of which are exported at low-values. This project will yield important knowledge in new synthetic techniques for making nanostructures of metal oxides. These tiny particles already have a large worldwide market, but the discovery of particles with superior properties or new applications could lead to new industries and high-value exports. This project aims to devise novel photocatalysts for solar energy conversion and environmental protection, and electrode materials for lithium batteries. It will contribute to the overall competitiveness and productivity of Australian R&D by advancing scientific knowledge and training young researchers.Read moreRead less
Formation and stability of polymerically stabilized colloids. This project will bring economic, medical and environmental benefits, with improved product performance and manufacturing processes for everyday industrial items relevant to a large industrial sector with significant employment in Australia: inks and paints (for example, surface coatings that can be applied more rapidly without clogging the jets); better means of preventing the fouling of industrial membranes; and improved materials f ....Formation and stability of polymerically stabilized colloids. This project will bring economic, medical and environmental benefits, with improved product performance and manufacturing processes for everyday industrial items relevant to a large industrial sector with significant employment in Australia: inks and paints (for example, surface coatings that can be applied more rapidly without clogging the jets); better means of preventing the fouling of industrial membranes; and improved materials for biomedical applications, with more desirable interactions between living cells and body fluids. These advances will also speed the replacement of solvent-based lacquer paints - detrimental to both environment and user - with water-based products of high quality.Read moreRead less
Chemical principles underpinning a spermostatic-microbiostatic agent capable of preventing pregnancy and the spread of sexually transmitted disease. This project explores the development of a method for simultaneously controlling fertility while preventing the spread of sexually transmitted diseases. A novel aspect of the approach, that will dramatically influence product development, is that the active principles will only be generated on contact with seminal plasma.
Enhancing neurogenesis in the adult primate brain. New neurons are robustly generated in the subependymal zone (SEZ) during human development. Thus, the SEZ may represent an endogenous modifiable source of neurons to enhance plasticity and therapeutic potential in the brain. However, despite our preliminary data, SEZ neurogenesis beyond the first months of life is controversial. This project aims to understand changes in the capacity for human SEZ proliferation from birth through to ageing and w ....Enhancing neurogenesis in the adult primate brain. New neurons are robustly generated in the subependymal zone (SEZ) during human development. Thus, the SEZ may represent an endogenous modifiable source of neurons to enhance plasticity and therapeutic potential in the brain. However, despite our preliminary data, SEZ neurogenesis beyond the first months of life is controversial. This project aims to understand changes in the capacity for human SEZ proliferation from birth through to ageing and whether neurogenesis may be induced by inflammation in the adult. Using transcriptomics we will also determine how the neurogenic environment changes with age/inflammation. This project is an important step in proving that the brain's potential to generate new neurons extends beyond infancy.Read moreRead less
Meshes of Oxide Nanofibres for Next-Generation Ceramic Membranes. Our next-generation ceramic membranes will increase the speed and efficiency of present industrial separations as well as expanding into a variety of new separations, thereby transforming many Australian industries. Exports of this new technology also will generate significant national benefits. Application of these new membranes to removing pollutants and pathogens from water and/or air will bring significant community benefits g ....Meshes of Oxide Nanofibres for Next-Generation Ceramic Membranes. Our next-generation ceramic membranes will increase the speed and efficiency of present industrial separations as well as expanding into a variety of new separations, thereby transforming many Australian industries. Exports of this new technology also will generate significant national benefits. Application of these new membranes to removing pollutants and pathogens from water and/or air will bring significant community benefits globally, addressing such crucial issues as low-cost provision of clean drinking water. Additionally, understanding the cutting-edge science associated with the mechanisms of nanofibre growth and the assembly of nanofibre meshes is highly valuable, making an important contribution to Australia's knowledge-economy.Read moreRead less