Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100220
Funder
Australian Research Council
Funding Amount
$180,000.00
Summary
Fluorescence and internal reflection system to develop lab-on-chip devices. Fluorescence and internal reflection system to develop lab-on-chip devices:
The aim of this project is to develop and establish a state-of-the-art fluorescence imaging facility. It aims to establish a total internal reflection fluorescence microscope combined with high speed epifluorescence imaging workstation that will be tailored to specifically investigate the fundamentals of blood cell, and vascular cell function. T ....Fluorescence and internal reflection system to develop lab-on-chip devices. Fluorescence and internal reflection system to develop lab-on-chip devices:
The aim of this project is to develop and establish a state-of-the-art fluorescence imaging facility. It aims to establish a total internal reflection fluorescence microscope combined with high speed epifluorescence imaging workstation that will be tailored to specifically investigate the fundamentals of blood cell, and vascular cell function. The project forms part of a broad bioengineering research program aimed at developing novel lab-on-chip technologies for basic cell biology and haematology. Outcomes from these projects may have significant impact in fundamental research in both bioengineering and biology disciplines.Read moreRead less
Examining novel cell signalling in the regulation of platelet structure and function. Pharmaceutical inhibition of platelet function is the primary therapy for prevention of arterial thrombosis – the most common cause of death and disability in Australia. However, current therapies have limited efficacy. Defining platelet activation mechanisms in order to rationalise more effective antithrombotic approaches is the major focus of this research. This project describes the first studies to examine ....Examining novel cell signalling in the regulation of platelet structure and function. Pharmaceutical inhibition of platelet function is the primary therapy for prevention of arterial thrombosis – the most common cause of death and disability in Australia. However, current therapies have limited efficacy. Defining platelet activation mechanisms in order to rationalise more effective antithrombotic approaches is the major focus of this research. This project describes the first studies to examine the importance of a family of intracellular signalling enzymes, the Class II phosphoinositide 3-kinases, in platelet function. These studies will define the contribution of these enzymes to platelet production and function and will establish whether their inhibition is an attractive strategy for the prevention of arterial thrombosis.Read moreRead less