Selective enrichment of proteins using micro-Gradiflow technology and characterisation of proteins using LC-MS/MS. This project describes crucial areas for the technology development of protein enrichment and fractionation. While current techniques are powerful, the usefulness to identify and characterise proteins of low abundance from massively complex samples in the presence of abundant proteins is limited and requires up to mililitre volumes. We intend to develop the micro-Gradiflow technolog ....Selective enrichment of proteins using micro-Gradiflow technology and characterisation of proteins using LC-MS/MS. This project describes crucial areas for the technology development of protein enrichment and fractionation. While current techniques are powerful, the usefulness to identify and characterise proteins of low abundance from massively complex samples in the presence of abundant proteins is limited and requires up to mililitre volumes. We intend to develop the micro-Gradiflow technology in association with Gradipore as a means of protein fractionation using microlitre volumes of sample. This technology will be applicable to all areas of proteomic research and in particular to the study of cell differentiation. The outcome for Australian industry, our competitiveness both industrial and scientific, and the potential for economic advancement is tremendous.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989491
Funder
Australian Research Council
Funding Amount
$172,025.00
Summary
Multi-Purpose Mass Spectrometry Facility. The Australian Centre for Research on Separation Science (ACROSS) has been established using focused research themes to provide both fundamental and applied research outcomes in separation science. The requested Time of Flight Mass Spectrometer (TOFMS) will be utilised extensively by a large team of researchers working across the broad areas of analytical chemistry, pharmaceutical science, materials science, biochemistry, microfluidics, industrial chemi ....Multi-Purpose Mass Spectrometry Facility. The Australian Centre for Research on Separation Science (ACROSS) has been established using focused research themes to provide both fundamental and applied research outcomes in separation science. The requested Time of Flight Mass Spectrometer (TOFMS) will be utilised extensively by a large team of researchers working across the broad areas of analytical chemistry, pharmaceutical science, materials science, biochemistry, microfluidics, industrial chemistry and hydrometallurgy, aquaculture, forensic analysis, Antarctic studies, and environmental monitoring. This will directly support our work falling under National Research Priorities 1 An Environmentally Sustainable Australia, 2 Promoting and Maintaining Good Health, 3 Frontier Technologies for Building and Transforming Australian Industries, and 4 Safeguarding Australia.Read moreRead less
Early Career Industry Fellowships - Grant ID: IE230100048
Funder
Australian Research Council
Funding Amount
$466,097.00
Summary
Ammonium-selective membranes to shift water industry into circular economy. The project aims to develop ammonium-selective membranes which are urgently needed in Australian key industries for sustainable ammonia recovery. The project expects to construct the membranes to achieve desirable pore size and surface functionality for fast and selective ammonia transport. The developed membranes should make ammonia recovery from wastewater more effective and sustainable, leading to the healthy waterway ....Ammonium-selective membranes to shift water industry into circular economy. The project aims to develop ammonium-selective membranes which are urgently needed in Australian key industries for sustainable ammonia recovery. The project expects to construct the membranes to achieve desirable pore size and surface functionality for fast and selective ammonia transport. The developed membranes should make ammonia recovery from wastewater more effective and sustainable, leading to the healthy waterway and reduced energy for both ammonia production and removal. Recovered ammonia expects to produce valuable products, supporting agriculture industry and hydrogen economy. The developed membranes should enable water industry's shift into circular economy, providing significant economic and environmental benefits to Australia.Read moreRead less
A novel ion-selective membrane for efficient lithium recovery . This project aims to fabricate a novel membrane that display selective lithium recovery from brine in a renewable energy driven electrochemical membrane technology. The fabrication of lithium selective membranes embedded with nanomaterials and metal organic framework will create new knowledge on the dynamics of ion-size sieving and accelerating lithium transportation. This project will provide significant environmental and economic ....A novel ion-selective membrane for efficient lithium recovery . This project aims to fabricate a novel membrane that display selective lithium recovery from brine in a renewable energy driven electrochemical membrane technology. The fabrication of lithium selective membranes embedded with nanomaterials and metal organic framework will create new knowledge on the dynamics of ion-size sieving and accelerating lithium transportation. This project will provide significant environmental and economic benefit by establishing a rapid and chemical free method to recover lithium affordably and orders of magnitude more efficiently than hard rock extraction. This project will bring significant commercial benefits to Australian mining industry, desalination and water treatment sectors.Read moreRead less
Optimising Removal of Proteinaceous Foulants from Membranes. Removal of proteinacous foulants from membrane systems imposes both significant economic costs in terms of chemical usage as well as significant environmental costs in terms of water usage and production of effluents from the cleaning and rinsing waters. The outcome of this project should allow us to develop methods for the prediction and optimisation of membrane cleaning performance of relevance to major Australian industries includin ....Optimising Removal of Proteinaceous Foulants from Membranes. Removal of proteinacous foulants from membrane systems imposes both significant economic costs in terms of chemical usage as well as significant environmental costs in terms of water usage and production of effluents from the cleaning and rinsing waters. The outcome of this project should allow us to develop methods for the prediction and optimisation of membrane cleaning performance of relevance to major Australian industries including the dairy, food processing and water and waste water treatment industries.Read moreRead less
Optimisation of nutrient removal, membrane fouling and sludge dewatering in hybrid coagulation/submerged membrane bioreactor treatment of wastewaters. Submerged membrane bioreactor technology for the treatment of wastewaters is now a competitive technology with small footprint and generally high quality of treated effluent. Despite this, challenges remain in ensuring low effluent nutrient concentrations, minimal membrane fouling and acceptable excess sludge dewaterability. Addition of iron or a ....Optimisation of nutrient removal, membrane fouling and sludge dewatering in hybrid coagulation/submerged membrane bioreactor treatment of wastewaters. Submerged membrane bioreactor technology for the treatment of wastewaters is now a competitive technology with small footprint and generally high quality of treated effluent. Despite this, challenges remain in ensuring low effluent nutrient concentrations, minimal membrane fouling and acceptable excess sludge dewaterability. Addition of iron or aluminium-based coagulant chemicals can assist but many uncertainties with regard to choice of chemical, optimal dosing arrangements and membrane bioreactor operating conditions remain. Experimental and computational studies targeted at improving understanding and optimising performance will be undertaken through collaborative studies by the UNSW and Tsinghua University (Beijing) research team.Read moreRead less
The Development of New Carrier Technologies for Spray-Dried Fruit Extracts. This project aims to develop new carrier techniques for spray drying fruit extracts based on the use of natural fibres, with the aim of overcoming a key problem in the operation of spray dryers for producing powders, the deposition of particles on walls. Carriers are non-sticky materials that effectively dilute the stickiness of any materials. The significance is that it will use waste products from fruit processing (th ....The Development of New Carrier Technologies for Spray-Dried Fruit Extracts. This project aims to develop new carrier techniques for spray drying fruit extracts based on the use of natural fibres, with the aim of overcoming a key problem in the operation of spray dryers for producing powders, the deposition of particles on walls. Carriers are non-sticky materials that effectively dilute the stickiness of any materials. The significance is that it will use waste products from fruit processing (the fibres from skins) to overcome this problem, and it will also be possible to dry sticky materials using material from the fruit itself, rather than additives such as maltodextrin.Read moreRead less
Highly Efficient Nanomotors for Autonomous Cell Recognition and Isolation. This project aims to develop next-generation self-driven nanomotors capable of long-range motion with highly controlled directionality for cell recognition, transportation and separation in complex biological environments, to allow autonomous and seamless cell sorting with high accuracy. The anticipated goal of this project is to advance the field of nanotechnology and advanced manufacturing with potential to support new ....Highly Efficient Nanomotors for Autonomous Cell Recognition and Isolation. This project aims to develop next-generation self-driven nanomotors capable of long-range motion with highly controlled directionality for cell recognition, transportation and separation in complex biological environments, to allow autonomous and seamless cell sorting with high accuracy. The anticipated goal of this project is to advance the field of nanotechnology and advanced manufacturing with potential to support new applications and to value-add Australia’s advanced manufacturing industry, presenting new opportunities for Australian MedTech industries with innovative, disruptive technologies to address its unique needs and to claim Australia’s position within the competitive global market.Read moreRead less
Characterisation and Treatment of Reverse Osmosis Concentrates from Water Recycling Applications. Concentrates from reverse osmosis (RO) pose a considerable threat to both the environment but also the successful implementation of reverse osmosis as a technology. Naturally, the concentrate contains everything that the RO retains and hence contaminants such as viruses, organics such as pharmaceutically active compounds and hormones as well as nutrients and salinity. Treatment of such waste streams ....Characterisation and Treatment of Reverse Osmosis Concentrates from Water Recycling Applications. Concentrates from reverse osmosis (RO) pose a considerable threat to both the environment but also the successful implementation of reverse osmosis as a technology. Naturally, the concentrate contains everything that the RO retains and hence contaminants such as viruses, organics such as pharmaceutically active compounds and hormones as well as nutrients and salinity. Treatment of such waste streams will enhance the health of receiving water bodies and reduce the risk of increased build up of contaminants if wastes are recycled into wastewater treatment plants. New ways to treat such contaminants will be explored, the efficiency and cost evaluated in the broader water cycle and sustainability framework.Read moreRead less
Characterising post-translational modifications in bacterial proteins. This project represents the first global attempt to characterize post-translational modifications in bacterial proteins using the tools of proteomics. Modifications to proteins are key elements in altering their function. In bacteria, modifications are important in cell-cell adhesion, signalling and triggering of the immune response. Characterisation of modified proteins and their sites of modification represents an opportuni ....Characterising post-translational modifications in bacterial proteins. This project represents the first global attempt to characterize post-translational modifications in bacterial proteins using the tools of proteomics. Modifications to proteins are key elements in altering their function. In bacteria, modifications are important in cell-cell adhesion, signalling and triggering of the immune response. Characterisation of modified proteins and their sites of modification represents an opportunity to understand how bacterial cell populations communicate in the environment, as well as aid in understanding pathogenesis in medical, veterinary and food-borne pathogens. Therefore, improved vaccine targets and therapeutics, as well as method-based products, may be generated by this project.Read moreRead less