Anti-ageing role for relaxin in blood vessels. Arteries stiffen with age. This is due to increased arterial smooth muscle tone and alterations in the extracellular matrix. In a sense, the artery undergoes ?fibrosis? with aging. In light of the anti-fibrotic attributes of the peptide hormone relaxin observed in other tissues, this collaborative project will investigate the potential role for relaxin in opposing arterial ?fibrosis? associated with aging. We will test the hypothesis that a reductio ....Anti-ageing role for relaxin in blood vessels. Arteries stiffen with age. This is due to increased arterial smooth muscle tone and alterations in the extracellular matrix. In a sense, the artery undergoes ?fibrosis? with aging. In light of the anti-fibrotic attributes of the peptide hormone relaxin observed in other tissues, this collaborative project will investigate the potential role for relaxin in opposing arterial ?fibrosis? associated with aging. We will test the hypothesis that a reduction in arterial relaxin expression in older animals is a major cause of arterial stiffening. Further studies will investigate the mechanisms by which relaxin administration can alleviate this phenomenon.Read moreRead less
Understanding how the brain uses sensory information to guide reaching and grasping movements. Reaching, grasping and manipulating objects are crucial aspects of our daily lives, which are performed so effortlessly that they tend to be taken for granted. We know however that these functions take a relatively long time to mature (think of a baby learning how to get an object), and that they can be impaired by brain lesions involving a region called the posterior parietal cortex. We also know that ....Understanding how the brain uses sensory information to guide reaching and grasping movements. Reaching, grasping and manipulating objects are crucial aspects of our daily lives, which are performed so effortlessly that they tend to be taken for granted. We know however that these functions take a relatively long time to mature (think of a baby learning how to get an object), and that they can be impaired by brain lesions involving a region called the posterior parietal cortex. We also know that this region has multiple subdivisions, but how exactly these interact in allowing the sensory information to guide arm and hand muscles is unknown. Discovering how this happens in terms of cellular interaction can have profound implications for the creation of new technologies such as artificial limbs and autonomous robots, and result in health benefits.Read moreRead less
High temperature limits of leaf function. In arid and semi-arid central Australia, Acacia spp. dominate the over-storey, but this shifts to Eucalyptus and Corymbia spp. in more mesic coastal regions. Areas of central Australia are extremely hot, dry and sunny, and it is this combination of stresses that likely excludes Eucalyptus spp. from many landforms. There has been little research on high temperature tolerance of Acacia and Eucalyptus, despite the putative importance of this stress, in co ....High temperature limits of leaf function. In arid and semi-arid central Australia, Acacia spp. dominate the over-storey, but this shifts to Eucalyptus and Corymbia spp. in more mesic coastal regions. Areas of central Australia are extremely hot, dry and sunny, and it is this combination of stresses that likely excludes Eucalyptus spp. from many landforms. There has been little research on high temperature tolerance of Acacia and Eucalyptus, despite the putative importance of this stress, in combination with other stresses, in limiting species? distributions. Our program of collaborative research will examine the tolerance of Acacia and Eucalyptus to a combination of high temperatures, drought and high light.Read moreRead less
Characterisation of insulin-independent glucose uptake mediated by guanine nucleotide-binding proteins (G-proteins) coupled receptors. This project will provide first class postdoctoral training for Dr Sato in the laboratory of A/Prof Bengtsson one of the pioneers in the field of cell metabolism. He will learn new approaches to the study of cell signalling including the use of ribonucleic acid interference (RNAi) technologies and of a series of functionally altered mutants of phosphatidylinosito ....Characterisation of insulin-independent glucose uptake mediated by guanine nucleotide-binding proteins (G-proteins) coupled receptors. This project will provide first class postdoctoral training for Dr Sato in the laboratory of A/Prof Bengtsson one of the pioneers in the field of cell metabolism. He will learn new approaches to the study of cell signalling including the use of ribonucleic acid interference (RNAi) technologies and of a series of functionally altered mutants of phosphatidylinositol (PI) 3-kinase that he will bring back to Monash University. A better understanding of the cell signalling mechanisms involved in glucose transport will be of enormous benefit in developing new approaches to the treatment of diseases such as type II diabetes.Read moreRead less
A microscopical examination of curdlan production by an Agrobacterium sp. We will investigate the secretion of the insoluble polysaccharide curdlan, a (1,3)-beta-glucan, from the surfaces of Agrobacterium cells and the assembly of the individual polysaccharide chains into microfibrils. Using state-of-the-art techniques in time lapse and electron microscopy we will compare the images of wild type curdlan-producing cells with those of mutants impaired in the production of curdlan. The outputs will ....A microscopical examination of curdlan production by an Agrobacterium sp. We will investigate the secretion of the insoluble polysaccharide curdlan, a (1,3)-beta-glucan, from the surfaces of Agrobacterium cells and the assembly of the individual polysaccharide chains into microfibrils. Using state-of-the-art techniques in time lapse and electron microscopy we will compare the images of wild type curdlan-producing cells with those of mutants impaired in the production of curdlan. The outputs will be information on the mechanics of curdlan production that will complement that emerging from our molecular biological and biochemical studies. These will have implications for understanding bacterial polysaccharide production in general and may have a commercial outcome in enhanced curdlan production.Read moreRead less
Regulation of proteolysis by specialised adaptor proteins. Training research scientists of the future forms an integral part of this research program and this collaboration will provide an excellent opportunity for young Australian scientists to be exposed to the very professional and competitive environment of basic research, as it exists in Germany. It will expose early career researchers to new ideas and emerging methodologies arming them with valuable skills, which they will transfer to Aust ....Regulation of proteolysis by specialised adaptor proteins. Training research scientists of the future forms an integral part of this research program and this collaboration will provide an excellent opportunity for young Australian scientists to be exposed to the very professional and competitive environment of basic research, as it exists in Germany. It will expose early career researchers to new ideas and emerging methodologies arming them with valuable skills, which they will transfer to Australia. The involvement of Prof. Turgay in the Deutsche Forschungsgemeinschaft (DFG) Priority Programme: Proteolysis in Prokaryotes also provides a unique opportunity for these young researchers to interact with several of the worlds leading scientists in the area of proteolysis, enhancing Australia's reputation at the forefront of science.Read moreRead less
Molecular basis of the antifungal and antimalarial activity of a plant defensin. The plant defensin NaD1 has potent inhibitory activity against a number of agronomically important fungal pathogens. These species are major pathogens of cotton and other important agricultural crops such as canola and potatoes. These pathogens cause serious economic losses and threaten the future of the cotton industry in Australia. NaD1 also has potential as a new antibiotic for treatment of infections in human ....Molecular basis of the antifungal and antimalarial activity of a plant defensin. The plant defensin NaD1 has potent inhibitory activity against a number of agronomically important fungal pathogens. These species are major pathogens of cotton and other important agricultural crops such as canola and potatoes. These pathogens cause serious economic losses and threaten the future of the cotton industry in Australia. NaD1 also has potential as a new antibiotic for treatment of infections in humans.Read moreRead less
A unified approach to studies on mitochondrial biogenesis. Mitochondria supply the cell with the majority of its energy as well as performing other key functions. How mitochondrial processes are regulated within the cell is an important area of biology. The broad aims of this collaboration are to analyse processes involved in mitochondrial biogenesis using yeast and mammalian cells as model systems. In particular the protein import processes and mitochondrial stress responses will be studied. Th ....A unified approach to studies on mitochondrial biogenesis. Mitochondria supply the cell with the majority of its energy as well as performing other key functions. How mitochondrial processes are regulated within the cell is an important area of biology. The broad aims of this collaboration are to analyse processes involved in mitochondrial biogenesis using yeast and mammalian cells as model systems. In particular the protein import processes and mitochondrial stress responses will be studied. The outcomes of this work will enable us to gain an appreciation of the similarities and differences in processes that exist between organisms so that general, unifying models can be made.Read moreRead less
Pharmacological and biochemical characterisation of Australian mygalomorph spider venoms. This project will increase our limited knowledge of Australian mygalomorph venoms by isolation, identification and characterisation of novel toxins in theraphosid and Northern mouse-spider venoms. Thereby, the scientific basis for the treatment of mygalomorph spider bites might be improved. Secondly, new insights into pharmacology and the potential development of novel therapeutics and molecular probes of t ....Pharmacological and biochemical characterisation of Australian mygalomorph spider venoms. This project will increase our limited knowledge of Australian mygalomorph venoms by isolation, identification and characterisation of novel toxins in theraphosid and Northern mouse-spider venoms. Thereby, the scientific basis for the treatment of mygalomorph spider bites might be improved. Secondly, new insights into pharmacology and the potential development of novel therapeutics and molecular probes of target molecules might be expected.Read moreRead less
New inhibitors of HIV based on cellular enzymes. Over 39 million people are infected with HIV worldwide. However, none of the most highly affected countries have yet reached the peak in AIDS-related illness and death, thus the global impact of HIV/AIDS will get significantly worse, before it gets better.
In Australia, HIV is again on the rise. Ironically, improved treatments that have extended life expectancy will cause the number of HIV infected Australians to rise for many years to come. ....New inhibitors of HIV based on cellular enzymes. Over 39 million people are infected with HIV worldwide. However, none of the most highly affected countries have yet reached the peak in AIDS-related illness and death, thus the global impact of HIV/AIDS will get significantly worse, before it gets better.
In Australia, HIV is again on the rise. Ironically, improved treatments that have extended life expectancy will cause the number of HIV infected Australians to rise for many years to come. Therefore many Australians will suffer from the combined impact of the AIDS illness itself, opportunistic infections, the side-effects of treatment and natural aging. We aim to develop new drugs to combat this disease to help people everywhere lead happier, healthier and more productive lives.Read moreRead less