Detecting stress-induced changes to subcellular copper pools in brain cells. Copper (Cu) plays essential roles in the functioning of brain cells, but the regulation and activity of this metal is poorly understood. This project aims to map sub-cellular Cu pools in brain cells, with particular emphasis on the effects of cellular stresses on these pools. These studies are expected to contribute important new methods for the study of Cu biology, and could provide valuable information about how Cu ho ....Detecting stress-induced changes to subcellular copper pools in brain cells. Copper (Cu) plays essential roles in the functioning of brain cells, but the regulation and activity of this metal is poorly understood. This project aims to map sub-cellular Cu pools in brain cells, with particular emphasis on the effects of cellular stresses on these pools. These studies are expected to contribute important new methods for the study of Cu biology, and could provide valuable information about how Cu homeostasis is maintained or perturbed under various stresses. In the future, this work is expected to form the basis of studies of brain Cu pools in neurodegenerative diseases.Read moreRead less
Revisiting the 'Fourth Age': health, socioeconomic and cultural transformation of, and diversity in, Australia's oldest old population, 1981-2011. The oldest-old (those aged 85 years and over) is the fastest growing segment of the Australian population, and the changing make-up and experiences of this group needs attention. This project will expand our knowledge base about Australia's oldest old, helping to inform public policy and to improve discussions on what the 'Fourth Age' really means in ....Revisiting the 'Fourth Age': health, socioeconomic and cultural transformation of, and diversity in, Australia's oldest old population, 1981-2011. The oldest-old (those aged 85 years and over) is the fastest growing segment of the Australian population, and the changing make-up and experiences of this group needs attention. This project will expand our knowledge base about Australia's oldest old, helping to inform public policy and to improve discussions on what the 'Fourth Age' really means in Australia.Read moreRead less
Social relations and social engagement in older adulthood: implications for health, well being and cognition. This project will examine the nature of changes in peoples' social networks that occur with age, and the effects of these changes on health and well being in later life. The project will use information collected from several ongoing Australian studies of ageing, and will have important implications for social policy in Australia.
Meeting the needs of older persons in Indonesia. The project aims to identify the needs of older people in rural Indonesia for income, housing, health, daily care and social interaction and the extent to which their needs are met. It also considers the efficacy of existing policy programs and how these might be improved. Today, there are 22 million Indonesians aged 60 years and over, projected to rise to 48 million by 2035. Millions of older people live in rural areas from which younger people h ....Meeting the needs of older persons in Indonesia. The project aims to identify the needs of older people in rural Indonesia for income, housing, health, daily care and social interaction and the extent to which their needs are met. It also considers the efficacy of existing policy programs and how these might be improved. Today, there are 22 million Indonesians aged 60 years and over, projected to rise to 48 million by 2035. Millions of older people live in rural areas from which younger people have moved to the rapidly growing cities. This presents challenges for the traditional family-based aged care system in Indonesia. It is expected that findings from the study will be published in a series of policy papers to be presented in the Indonesian National Development Planning Board.Read moreRead less
Improving neuronal cell function with cell permeable copper complexes. Metal-based drugs offer an exciting new approach to treatment of neurodegeneration. However, little is known about how cells metabolise these drugs and this information is critical for further drug development. This project will determine how metal-based drugs are metabolised by neuronal cells and how this may result in therapeutic benefit.
Understanding old age in Australian history as a foundation for improved social and economic policy. My history of old age in Australia since 1860 will provide the first book which maps our experiences of growing old in the past, as a foundation for improved social and economic policy. The national government's 'Inter-generational report' has started a process of review and planning at a time of dramatic demographic change. However, developing strategies for 'ageing well, ageing productively' d ....Understanding old age in Australian history as a foundation for improved social and economic policy. My history of old age in Australia since 1860 will provide the first book which maps our experiences of growing old in the past, as a foundation for improved social and economic policy. The national government's 'Inter-generational report' has started a process of review and planning at a time of dramatic demographic change. However, developing strategies for 'ageing well, ageing productively' depends on an informed understanding of previous and current expectations about and attitudes to ageing in Australia. The history of old age is a complex rather than simple story, and successful policy development will require a solid historical foundation.Read moreRead less
Behaviour and emotional problems in young children with developmental delay. This research will provide health professionals, researchers and service providers with a reliable and valid measure to assess behaviour in young children with developmental delay. This will be the first instrument of its kind worldwide. The study will provide the largest and most comprehensive survey of behaviour and emotional problems in young children with developmental delay internationally to date. It will provide ....Behaviour and emotional problems in young children with developmental delay. This research will provide health professionals, researchers and service providers with a reliable and valid measure to assess behaviour in young children with developmental delay. This will be the first instrument of its kind worldwide. The study will provide the largest and most comprehensive survey of behaviour and emotional problems in young children with developmental delay internationally to date. It will provide information on the types of treatment that are needed for these children and what support is needed for their families. The outcomes of this study have the potential to promote the best possible start in life and long term mental health of this group of at risk and disadvantaged young Australians.Read moreRead less
Discovering sources of individual differences in first language acquisition. This project aims to investigate the processes of language acquisition to support the development of evidence-based strategies for improving children's early language. Some children learn language earlier and more easily than others. Understanding why this is the case is important because successful acquisition is strongly associated with positive life outcomes such as academic achievement and psychological wellbeing. T ....Discovering sources of individual differences in first language acquisition. This project aims to investigate the processes of language acquisition to support the development of evidence-based strategies for improving children's early language. Some children learn language earlier and more easily than others. Understanding why this is the case is important because successful acquisition is strongly associated with positive life outcomes such as academic achievement and psychological wellbeing. This project focuses on typically developing children, investigating how their ability to detect frequently occurring patterns in the environment significantly contributes to their acquisition of grammar in early childhood. The project plans to use an innovative triangulation of experimental methods from developmental psychology, longitudinal analysis and cognitive modelling to drive the development of new models of language acquisition and transform our understanding of both typical and atypical acquisition.Read moreRead less
The Shape of Plants; Discovering factors that control morphology by organizing the cytoskeleton. Understanding how plants generate the huge diversity of shapes seen in nature is both a scientific challenge and a biotechnological opportunity. Microtubules dominate cell architecture, providing dynamic, yet rigid, frameworks for defining or changing growth polarity. We recently discovered and cloned MOR1, a gene that is essential for organizing microtubules and controlling morphogenesis. This place ....The Shape of Plants; Discovering factors that control morphology by organizing the cytoskeleton. Understanding how plants generate the huge diversity of shapes seen in nature is both a scientific challenge and a biotechnological opportunity. Microtubules dominate cell architecture, providing dynamic, yet rigid, frameworks for defining or changing growth polarity. We recently discovered and cloned MOR1, a gene that is essential for organizing microtubules and controlling morphogenesis. This places us in a strong position to resolve a long-standing mystery: how are microtubules organized? We intend to define MOR1's structural attributes, identify its interacting proteins and innovate an ambitious screen for additional genes that have related functions. This project should stimulate new ideas and applications.Read moreRead less
CesA (cellulose synthase) genes of Arabidopsis; all doing the same job or specialists cooperating to make the most abundant biopolymer. The biosphere makes more cellulose than any other polymer with fibre industries depending on its physical properties and atmospheric carbon dioxide levels depending on its stability as a carbon sink. Demonstrations that cellulose production needs CesA genes drove recent progress in elucidating the mechanism of synthesis. CesA proteins all look very similar but i ....CesA (cellulose synthase) genes of Arabidopsis; all doing the same job or specialists cooperating to make the most abundant biopolymer. The biosphere makes more cellulose than any other polymer with fibre industries depending on its physical properties and atmospheric carbon dioxide levels depending on its stability as a carbon sink. Demonstrations that cellulose production needs CesA genes drove recent progress in elucidating the mechanism of synthesis. CesA proteins all look very similar but if all do the same job, why do plants need so many and why do none seem redundant? We will make gene interchanges in transgenic plants, build chimeric genes and identify where each CesA protein operates. This will identify their individual and cooperative contributions to cellulose production.Read moreRead less