Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0561229
Funder
Australian Research Council
Funding Amount
$518,427.00
Summary
Establishment of a Multiphoton Microscope Imaging Platform for Live Cell and Tissue, and Optical Imaging. This proposal seeks to establish a multidisciplinary multiphoton imaging laboratory, expanding the imaging capabilities of a Core Regional Imaging Facility. This Facility supports researchers across all Monash campuses and hospital-based research Schools, as well as outside research groups in the Victorian region. Furthermore, this equipment will support significant fiber optic research at V ....Establishment of a Multiphoton Microscope Imaging Platform for Live Cell and Tissue, and Optical Imaging. This proposal seeks to establish a multidisciplinary multiphoton imaging laboratory, expanding the imaging capabilities of a Core Regional Imaging Facility. This Facility supports researchers across all Monash campuses and hospital-based research Schools, as well as outside research groups in the Victorian region. Furthermore, this equipment will support significant fiber optic research at Victoria University for the development of communication and endoscopic technology. The instrument design will allow multiple use of the lightsource and choice of specific imaging devices (microscopes) to ensure that applications in biocellular imaging, intravital microscopy and fiber optic design and imaging are individually optimised.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0452977
Funder
Australian Research Council
Funding Amount
$329,504.00
Summary
Upgrade and expansion of Newcastle Plant Growth Facility. The project will upgrade and expand the Newcastle Plant Growth Facility. The upgrades will improve glasshouse environments for the production of high quality plant material. This outcome will be achieved through increasing solar transmittance and more effective temperature control. Expansion will address unmet demand for standard and PC2 plant growth space. Together the infrastructure additions will enhance productivity and excellence ....Upgrade and expansion of Newcastle Plant Growth Facility. The project will upgrade and expand the Newcastle Plant Growth Facility. The upgrades will improve glasshouse environments for the production of high quality plant material. This outcome will be achieved through increasing solar transmittance and more effective temperature control. Expansion will address unmet demand for standard and PC2 plant growth space. Together the infrastructure additions will enhance productivity and excellence of core areas of plant biology research at Newcastle in nutrient transport, cell development as well as environment management and rehabilitation . In addition, they will underpin new collaborative initiatives at the interfaces between plant biology with transgenic delivery of reproductive vaccines and phytoremediation.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347607
Funder
Australian Research Council
Funding Amount
$306,000.00
Summary
FishWorks - collaborative infrastructure for zebrafish research. Zebrafish have emerged as a powerful and cost-effective animal model for studying development, biology, and disease. FishWorks represents a large-scale co-operative initiative to develop state-of-the-art zebrafish housing, manipulation, genomics and screening infrastructure in Australia. This will both support and further enhance a core group of high quality researchers to engage in cutting-edge research in areas of acknowledged ex ....FishWorks - collaborative infrastructure for zebrafish research. Zebrafish have emerged as a powerful and cost-effective animal model for studying development, biology, and disease. FishWorks represents a large-scale co-operative initiative to develop state-of-the-art zebrafish housing, manipulation, genomics and screening infrastructure in Australia. This will both support and further enhance a core group of high quality researchers to engage in cutting-edge research in areas of acknowledged expertise as well as priority within their respective institutions. In addition, it will facilitate wide-ranging collaborative arrangements to further develop and exploit this research area.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453839
Funder
Australian Research Council
Funding Amount
$386,892.00
Summary
Adelaide Core Laser Capture Microscopy Facility. Laser Capture Microscopy represents a powerful and essential tool in many aspects of modern cell and molecular biology. Although the applications for these machines are very broad, overall the technology can be viewed as allowing collection of rare cells (or objects as small as bacteria and organelles) from complex tissues and cells. This proposal concerns infrastructure funding to obtain a state-of-the-art core Laser Capture Microscope facility ....Adelaide Core Laser Capture Microscopy Facility. Laser Capture Microscopy represents a powerful and essential tool in many aspects of modern cell and molecular biology. Although the applications for these machines are very broad, overall the technology can be viewed as allowing collection of rare cells (or objects as small as bacteria and organelles) from complex tissues and cells. This proposal concerns infrastructure funding to obtain a state-of-the-art core Laser Capture Microscope facility in Adelaide that will significantly enhance scientific progress in a diverse range of areas including functional genomics of animal, plant and prokaryotic cells.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668241
Funder
Australian Research Council
Funding Amount
$824,610.00
Summary
A Facility for High-Throughput, Functional Gene Discovery Using Arrayed Retroviral Expression Cloning. The proposed facility will represent world-leading technology in functional genomics and provide Australian scientists with unique opportunities to identify genes involved in a broad range of biological processes. This will contribute to fundamental knowledge in mammalian biology, and equally importantly, is likely to identify genes involved in important health problems such as cancer, inflamma ....A Facility for High-Throughput, Functional Gene Discovery Using Arrayed Retroviral Expression Cloning. The proposed facility will represent world-leading technology in functional genomics and provide Australian scientists with unique opportunities to identify genes involved in a broad range of biological processes. This will contribute to fundamental knowledge in mammalian biology, and equally importantly, is likely to identify genes involved in important health problems such as cancer, inflammatory disease, brain damage and diabetes. Such genes may in turn constitute targets against which new therapies may be developed. This endeavour will contribute to national research priorities in both the health and scientific/technological development arenas.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775778
Funder
Australian Research Council
Funding Amount
$196,000.00
Summary
A microarray platform for gene expression analysis and genotyping in biological systems. This technology has substantial benefits for basic science and biotechnology. The ability to rapidly study changes in gene expression in living organisms will benefit agriculture, animal and biomedical science and biotechnology. The Affymetrix platform creates opportunities for new avenues of research, such as studying epigenetic (DNA and protein modifications) mechanisms in development, ageing and disease. ....A microarray platform for gene expression analysis and genotyping in biological systems. This technology has substantial benefits for basic science and biotechnology. The ability to rapidly study changes in gene expression in living organisms will benefit agriculture, animal and biomedical science and biotechnology. The Affymetrix platform creates opportunities for new avenues of research, such as studying epigenetic (DNA and protein modifications) mechanisms in development, ageing and disease. The project falls within the designated national research priority areas of 'promoting and maintaining good health" and the priority goals of "a healthy start to life", "aging well", "aging productively" and "preventative health care."Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100241
Funder
Australian Research Council
Funding Amount
$480,000.00
Summary
Adelaide Flow Cytometry Facility. This project aims to provide high-throughput fluorescence-activated Cell Sorting (FACS) and cytometric analysis with diverse applications in biological sciences. The project will expand an existing Gene Silencing and Expression (GSEx) Facility to sort and analyse cells, interfacing with genetic manipulation, genomics and pyrosequencing in an established service structure. This project is expected to advance eukaryotic cell biology, plant biology and microbiology ....Adelaide Flow Cytometry Facility. This project aims to provide high-throughput fluorescence-activated Cell Sorting (FACS) and cytometric analysis with diverse applications in biological sciences. The project will expand an existing Gene Silencing and Expression (GSEx) Facility to sort and analyse cells, interfacing with genetic manipulation, genomics and pyrosequencing in an established service structure. This project is expected to advance eukaryotic cell biology, plant biology and microbiology, and lead to innovation in stem cell technologies, animal breeding, food production and nutrition, mitigating environment change, and health. These outcomes are expected to boost Australia’s industries in tertiary education, primary production and technologies in the food / health / economy nexus.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775673
Funder
Australian Research Council
Funding Amount
$1,200,000.00
Summary
A high throughput protein crystallization & imaging facility. Protein crystallography is an important field of research that enables us to understand the precise shape of proteins. The precise shape of a protein determines the function of a protein. This information is essential in understanding the physiological role of a protein and may be used for the development of therapeutics, where approrpiate. We aim to develop a high-throughput robotics system that will enable us to determine the sh ....A high throughput protein crystallization & imaging facility. Protein crystallography is an important field of research that enables us to understand the precise shape of proteins. The precise shape of a protein determines the function of a protein. This information is essential in understanding the physiological role of a protein and may be used for the development of therapeutics, where approrpiate. We aim to develop a high-throughput robotics system that will enable us to determine the shape of many proteins more rapidly, thereby greatly accelerating the pace of biomedical research.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100202
Funder
Australian Research Council
Funding Amount
$255,120.00
Summary
Three-dimensional cryo correlative light and electron microscopy facility. This project aims to establish a three-dimensional (3D) cryo-correlative light and electron microscopy facility. The facility will integrate light microscopy with high resolution cryo-electron tomography and 3D slice-and-view focused ion beam scanning electron microscopy. The open access facility should create new capabilities for Australian researchers to tag biological events and structures with fluorescence markers and ....Three-dimensional cryo correlative light and electron microscopy facility. This project aims to establish a three-dimensional (3D) cryo-correlative light and electron microscopy facility. The facility will integrate light microscopy with high resolution cryo-electron tomography and 3D slice-and-view focused ion beam scanning electron microscopy. The open access facility should create new capabilities for Australian researchers to tag biological events and structures with fluorescence markers and image them using the currently highest resolution 3D imaging techniques for biological matter. The facility expects to reveal fundamental insights into cell and structural biology, and help drive innovation in agriculture, pharmaceutics, and biomaterials.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0346876
Funder
Australian Research Council
Funding Amount
$1,584,000.00
Summary
800 MHz NMR Spectrometer for Molecular Structure-Function Analyses. An 800 MHz high-resolution nuclear magnetic resonance (NMR) spectrometer equipped with a triple-resonance cryoprobe is required to support the research of 5 universities in the NSW/ACT area. The high magnetic field of the spectrometer is necessary for the study of proteins, protein-ligand complexes and other biomolecular systems of molecular weight >30,000. Projects previously inaccessible due to sensitivity, solubility or resol ....800 MHz NMR Spectrometer for Molecular Structure-Function Analyses. An 800 MHz high-resolution nuclear magnetic resonance (NMR) spectrometer equipped with a triple-resonance cryoprobe is required to support the research of 5 universities in the NSW/ACT area. The high magnetic field of the spectrometer is necessary for the study of proteins, protein-ligand complexes and other biomolecular systems of molecular weight >30,000. Projects previously inaccessible due to sensitivity, solubility or resolution problems will become tractable. The increased turn-around times afforded by the high sensitivity of the cryo-enabled spectrometer make it possible to provide access for Australian institutions that would not otherwise have access to comparable equipment.Read moreRead less