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A Media Formulation To Improve Implantation Rates And Pregnancy Outcome Following ART
Funder
National Health and Medical Research Council
Funding Amount
$304,380.00
Summary
Since women are delaying childbearing, ART is increasingly required. 2-3% of births in Australia follow ART. Only 15-40% of embryo transfers in assisted reproduction (ART) result in ongoing pregnancies. The poor success rate is due to the fact that the embryo culture media bear no resemblance to the maternal environment in which they grow normally. The new culture media to be validated in this proposal includes factors that are critical for embryo implantation and will improve ART success.
Media Formulations To Enhance Embryo Formation In Assisted Reproduction
Funder
National Health and Medical Research Council
Funding Amount
$660,133.00
Summary
The increasing age of parenthood has led to an explosion in the demand for assisted reproductive technologies such as in vitro fertilisation (IVF). This procedure has a poor success rate and is limited by the ability of fertilised eggs to mature into early embryos in the lab prior to being transferred into women. We will develop new compounds that improve embryo growth in the clinic, which will improve IVF success rates.
EGF Peptide Signalling Improves Oocyte Maturation And Quality
Funder
National Health and Medical Research Council
Funding Amount
$586,891.00
Summary
Infertility is common and although IVF is widely accepted, the procedure is expensive and is associated with health risks. Using laboratory animals, we have developed significant new insights into mechanisms regulating egg quality. These insights have allowed us to develop a new approach to infertility treatment - crucially, one that eliminates the need for ovarian hormone therapy used in IVF. This project will investigate the basic mechanisms underlying our new approach to enable safe clinical ....Infertility is common and although IVF is widely accepted, the procedure is expensive and is associated with health risks. Using laboratory animals, we have developed significant new insights into mechanisms regulating egg quality. These insights have allowed us to develop a new approach to infertility treatment - crucially, one that eliminates the need for ovarian hormone therapy used in IVF. This project will investigate the basic mechanisms underlying our new approach to enable safe clinical implementation.Read moreRead less
Infertility is common and although IVF is widely accepted, the procedure is expensive and is associated with health risks. Using laboratory animals, we have made significant advances towards developing new technologies that can mature eggs and produce embryos in vitro, but without women receiving hormone injections. This project will seek means to combine the benefits of two of our existing technologies into one integrated system, to provide hormone-free infertility treatment.
Discovery Early Career Researcher Award - Grant ID: DE230101466
Funder
Australian Research Council
Funding Amount
$442,723.00
Summary
Violent offenders in the night-time economy: Building the evidence. Alcohol-related violence in entertainment precincts is a significant community safety problem. This project aims to improve knowledge on individuals that are violent in entertainment precincts. It is expected to be the first study globally to use linked data to develop multi-system informed offending trajectories of violent offenders in these settings, examine the impact of patrons bans on offending trajectories, and apply situa ....Violent offenders in the night-time economy: Building the evidence. Alcohol-related violence in entertainment precincts is a significant community safety problem. This project aims to improve knowledge on individuals that are violent in entertainment precincts. It is expected to be the first study globally to use linked data to develop multi-system informed offending trajectories of violent offenders in these settings, examine the impact of patrons bans on offending trajectories, and apply situational action theory to alcohol-related violence. Results are expected to inform a critical knowledge gap and assist in the development of targeted violence preventive responses which reduce harm and make communities safer.Read moreRead less
Analysing and disrupting outlaw motorcycle gangs in Australia. This project aims to reveal the structure and social dynamics of co-offending networks by OMCGs in Australia. Outlaw motorcycle gangs (OMCGs) cause significant social and economic harm in Australia and internationally. The project will generate new knowledge about OMCG co-offending using an innovative multimethod approach combining social network analysis with interviews and focus groups. Expected outcomes include a deeper understand ....Analysing and disrupting outlaw motorcycle gangs in Australia. This project aims to reveal the structure and social dynamics of co-offending networks by OMCGs in Australia. Outlaw motorcycle gangs (OMCGs) cause significant social and economic harm in Australia and internationally. The project will generate new knowledge about OMCG co-offending using an innovative multimethod approach combining social network analysis with interviews and focus groups. Expected outcomes include a deeper understanding of OMCG criminal activity across Australia and refined theory development about co-offending in criminal groups. The project will lead to improved policy, legislation and policing practice to prevent OMCG crime and dismantle OMCG criminal networks in more cost-effective ways.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100359
Funder
Australian Research Council
Funding Amount
$420,960.00
Summary
Preventing crime in public spaces: everyday guardianship & territoriality . Safe public spaces are the cornerstone of liveable cities. Everyday users of public spaces are vital crime prevention guardians because they are frequently present in the absence of formal regulators like police. This project will investigate factors that enhance active guardianship and facilitate crime prevention in public spaces. It aims to generate new knowledge on the extent to which everyday users of public spaces d ....Preventing crime in public spaces: everyday guardianship & territoriality . Safe public spaces are the cornerstone of liveable cities. Everyday users of public spaces are vital crime prevention guardians because they are frequently present in the absence of formal regulators like police. This project will investigate factors that enhance active guardianship and facilitate crime prevention in public spaces. It aims to generate new knowledge on the extent to which everyday users of public spaces develop a sense of territorial control leading to conscious monitoring of public spaces and intervention in social problems. The project aims to inform crime prevention strategies that facilitate active guardianship leading to less crime, reduced fear of crime and enhanced opportunities for pro-social use of public spaces. Read moreRead less
Targeting early contact with the criminal justice system in young people. This project aims to identify who and why young people first come in contact with the criminal justice system and what determines the early course of contact. The project will focus on first police contact, as a victim, witness or offender, as a means of identifying young people at-risk of adverse life outcomes. It intends to build on the NSW Child Development Study, a large population-based intergenerational cohort, to de ....Targeting early contact with the criminal justice system in young people. This project aims to identify who and why young people first come in contact with the criminal justice system and what determines the early course of contact. The project will focus on first police contact, as a victim, witness or offender, as a means of identifying young people at-risk of adverse life outcomes. It intends to build on the NSW Child Development Study, a large population-based intergenerational cohort, to develop services and interventions aimed at preventing young people from becoming enmeshed in the criminal justice system.Read moreRead less
Targeted crime: policing and social inclusion. This project will undertake a criminological study of the policing of targeted incidents and crime, that is, incidents and crimes motivated by bias, prejudice or hatred towards members of particular groups, communities and individuals. It will develop a best practice policing framework for targeted crimes and incidents.
Understanding the emerging threat of conspiracy-fuelled extremism. This project aims to address the emerging threat of conspiracy-fuelled extremism in Australia. The project expects to produce new knowledge by identifying the unique factors driving this new form of extremism and the social harm it causes. Through three studies, the project will test a new theoretical model of conspiracy-fuelled extremism, will explore the threats and social harms this form of extremism creates, and will develop ....Understanding the emerging threat of conspiracy-fuelled extremism. This project aims to address the emerging threat of conspiracy-fuelled extremism in Australia. The project expects to produce new knowledge by identifying the unique factors driving this new form of extremism and the social harm it causes. Through three studies, the project will test a new theoretical model of conspiracy-fuelled extremism, will explore the threats and social harms this form of extremism creates, and will develop evidence-based insights into how it can be mitigated. The research should produce benefits for Australia by providing policymakers with a risk-assessment tool to identify individuals most 'at-risk' of violent extremism, and by providing knowledge about the services families may require to de-radicalise loved ones.Read moreRead less