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The presenilin proteins are key components in the development of Alzheimer's disease. Mutations in these proteins can cause early Alzheimer's disease. We will continue our study of the biochemistry and cell biology of these proteins using tools and experimental models that we have already developed. This will provide important information on the mechanism of the disease process and give new leads in the treatment of the disease. The new technologies of genetic screening for presenilin mutations ....The presenilin proteins are key components in the development of Alzheimer's disease. Mutations in these proteins can cause early Alzheimer's disease. We will continue our study of the biochemistry and cell biology of these proteins using tools and experimental models that we have already developed. This will provide important information on the mechanism of the disease process and give new leads in the treatment of the disease. The new technologies of genetic screening for presenilin mutations will be developed and utilized as a National referral base.Read moreRead less
Progressive Aphasia And Amyloid Deposition: A Multidisciplinary Approach To Improving Dementia Diagnosis
Funder
National Health and Medical Research Council
Funding Amount
$528,245.00
Summary
We aim to understand the role of amyloid deposition in the genesis of symptoms in Alzheimer's disease. Patients presenting with progressive deterioration of language (aphasia) some of whom are known to have Alzheimer's disease will be studied using brain imaging techniques, including a PET method (PiB) that labels amyloid in vivo, and to compare imaging changes with a range of language assessments. This will improve the early diagnosis and management of patients with progressive aphasia.
Music Therapy Interventions For Dementia: Cluster Randomised Control Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,014,430.00
Summary
Music therapy interventions are increasingly used in aged care facilities across Australia, however Australian-based research that tests its effectiveness is scarce. In this study, we track the impact of group music therapy and group singing on levels of depression, cognitive function, quality of life, and other symptoms of dementia. By providing music therapy programs across sites in Victoria, NSW and Queensland, we will also evaluate the cost effectiveness of the intervention.
Functional Genomic Analysis Of The Role Of P53 In Early Embryo Death After Assisted Reproductive Technologies (ART).
Funder
National Health and Medical Research Council
Funding Amount
$227,036.00
Summary
Assisted reproductive technologies (ART, such as IVF and related techniques) are successful treatments for most forms of infertility. ART are expensive therapies and much of this cost is related to the relative inefficiency of the technology. Much of this is due to the high mortality of the resulting embryos. Typically, 45-80% of embryos produced by ART do not survive the first week. Consequently the chance of any individual embryo resulting in a successful birth is not high. There has been only ....Assisted reproductive technologies (ART, such as IVF and related techniques) are successful treatments for most forms of infertility. ART are expensive therapies and much of this cost is related to the relative inefficiency of the technology. Much of this is due to the high mortality of the resulting embryos. Typically, 45-80% of embryos produced by ART do not survive the first week. Consequently the chance of any individual embryo resulting in a successful birth is not high. There has been only modest increments in embryo survival in recent years. The low cahnce of individual embryos resulting in a baby means that: (1) generally several treatment cycles are required; (2) superovulation is used to maximise the number of embryos produced giving an accumulation of unwanted cryopreserved embryos; (3) more than one embryo is generally transferred resulting in a significant incidence of multiple pregancies. The high mortality of the early embryo seems to be a general feature of IVF but its causes and effectors are not known. It has recently been established that it largely occurs due to a form of cell 'suicide' known as apoptosis. This form of cell death has important normal functions: its activation allows for cells that are no longer required to be removed, allowing the remodelling of tissues and it also serves to remove cells that are irreversibly damaged. p53 is a protein that has the ability to 'sense' cell stress and damage and to direct the cell to undergo apoptosis if the stress is severe. This project will examine if ART cause increased expression of p53 and whether this elevation of p53 causes embryonic cell death. We will examine the factirs that control p53 expression in the embryo. using mice with mutations that stop the function of p53 and several of its regulatory proteins. Experiments will determine the susceptibility of embryos possessing these mutations and will therefore allow us to define the proteins causing apoptosis after ART.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230101466
Funder
Australian Research Council
Funding Amount
$442,723.00
Summary
Violent offenders in the night-time economy: Building the evidence. Alcohol-related violence in entertainment precincts is a significant community safety problem. This project aims to improve knowledge on individuals that are violent in entertainment precincts. It is expected to be the first study globally to use linked data to develop multi-system informed offending trajectories of violent offenders in these settings, examine the impact of patrons bans on offending trajectories, and apply situa ....Violent offenders in the night-time economy: Building the evidence. Alcohol-related violence in entertainment precincts is a significant community safety problem. This project aims to improve knowledge on individuals that are violent in entertainment precincts. It is expected to be the first study globally to use linked data to develop multi-system informed offending trajectories of violent offenders in these settings, examine the impact of patrons bans on offending trajectories, and apply situational action theory to alcohol-related violence. Results are expected to inform a critical knowledge gap and assist in the development of targeted violence preventive responses which reduce harm and make communities safer.Read moreRead less
Analysing and disrupting outlaw motorcycle gangs in Australia. This project aims to reveal the structure and social dynamics of co-offending networks by OMCGs in Australia. Outlaw motorcycle gangs (OMCGs) cause significant social and economic harm in Australia and internationally. The project will generate new knowledge about OMCG co-offending using an innovative multimethod approach combining social network analysis with interviews and focus groups. Expected outcomes include a deeper understand ....Analysing and disrupting outlaw motorcycle gangs in Australia. This project aims to reveal the structure and social dynamics of co-offending networks by OMCGs in Australia. Outlaw motorcycle gangs (OMCGs) cause significant social and economic harm in Australia and internationally. The project will generate new knowledge about OMCG co-offending using an innovative multimethod approach combining social network analysis with interviews and focus groups. Expected outcomes include a deeper understanding of OMCG criminal activity across Australia and refined theory development about co-offending in criminal groups. The project will lead to improved policy, legislation and policing practice to prevent OMCG crime and dismantle OMCG criminal networks in more cost-effective ways.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100359
Funder
Australian Research Council
Funding Amount
$420,960.00
Summary
Preventing crime in public spaces: everyday guardianship & territoriality . Safe public spaces are the cornerstone of liveable cities. Everyday users of public spaces are vital crime prevention guardians because they are frequently present in the absence of formal regulators like police. This project will investigate factors that enhance active guardianship and facilitate crime prevention in public spaces. It aims to generate new knowledge on the extent to which everyday users of public spaces d ....Preventing crime in public spaces: everyday guardianship & territoriality . Safe public spaces are the cornerstone of liveable cities. Everyday users of public spaces are vital crime prevention guardians because they are frequently present in the absence of formal regulators like police. This project will investigate factors that enhance active guardianship and facilitate crime prevention in public spaces. It aims to generate new knowledge on the extent to which everyday users of public spaces develop a sense of territorial control leading to conscious monitoring of public spaces and intervention in social problems. The project aims to inform crime prevention strategies that facilitate active guardianship leading to less crime, reduced fear of crime and enhanced opportunities for pro-social use of public spaces. Read moreRead less
Feeding Disturbance And Hypothalamus Integrity In Early Frontotemporal Dementia
Funder
National Health and Medical Research Council
Funding Amount
$428,319.00
Summary
Frontotemporal dementia accounts for 12-20% of all dementia cases. It is as common as Alzheimer�s disease in the < 65 year olds but understanding of this disease remains limited. Marked eating disturbance (overeating, snatching food) is a common clinical manifestation. This project will characterise this deficit and define its biological causes using blood tests and magnetic resonance imaging. Results will help in designing therapeutic interventions targeting this disabling feature.
Discovery Of Novel Neurodegeneration Genes Via Next-generation Sequencing Technologies And High-throughput Cellular Assays
Funder
National Health and Medical Research Council
Funding Amount
$715,144.00
Summary
My research program aims to discover genes that are mutated in dementia, by identifying gene variants present in patients and absent in healthy people, and examining how these variants affect the function of cells. Identifying new dementia genes will reveal the biological processes that lead to brain cell death. Knowledge of these processes is crucial for the development of new treatments for the many people affected worldwide with dementia.
Targeting early contact with the criminal justice system in young people. This project aims to identify who and why young people first come in contact with the criminal justice system and what determines the early course of contact. The project will focus on first police contact, as a victim, witness or offender, as a means of identifying young people at-risk of adverse life outcomes. It intends to build on the NSW Child Development Study, a large population-based intergenerational cohort, to de ....Targeting early contact with the criminal justice system in young people. This project aims to identify who and why young people first come in contact with the criminal justice system and what determines the early course of contact. The project will focus on first police contact, as a victim, witness or offender, as a means of identifying young people at-risk of adverse life outcomes. It intends to build on the NSW Child Development Study, a large population-based intergenerational cohort, to develop services and interventions aimed at preventing young people from becoming enmeshed in the criminal justice system.Read moreRead less