Methylation As A Risk And Prognostic Factor For Breast Cancer
Funder
National Health and Medical Research Council
Funding Amount
$594,913.00
Summary
DNA methylation is a process playing critical roles throughout life by altering the expression of genes. This study aims to investigate the potential use of methylation as marker of risk and early diagnosis of breast cancer in women with no clinical evidence of disease and marker of prognosis and response to treatment in breast cancer cases.
The Australian Parkinson's Project - Uncovering Genetic Risk Factors For Sporadic PD
Funder
National Health and Medical Research Council
Funding Amount
$768,546.00
Summary
Parkinson s disease (PD) is a progressively disabling movement disorder afflicting many elderly Australians. It is caused by the degeneration of specific nerve cells in the brain that produce certain chemicals and patients suffer from an inability to move fluently (or ultimately at all). At present we do not know what triggers this neurodegeneration, but it is believed that complex interactions between inherited (genetic) and environmental factors contribute significantly to the phenomenon. This ....Parkinson s disease (PD) is a progressively disabling movement disorder afflicting many elderly Australians. It is caused by the degeneration of specific nerve cells in the brain that produce certain chemicals and patients suffer from an inability to move fluently (or ultimately at all). At present we do not know what triggers this neurodegeneration, but it is believed that complex interactions between inherited (genetic) and environmental factors contribute significantly to the phenomenon. This project aims to learn more about these complex interactions and their association with PD. People with PD and unaffected individuals will be recruited from throughout Australia and we will look for specific combinations of genetic, environmental and lifestyle factors that either increase or decrease an individual's risk for PD. This research will identify the most common dominant genetic and environmental influences for PD in Australia, enabling scientists to focus on the most relevant biological pathways to target therapeutically.Read moreRead less
A Case Control Study Of Risk Factors For Aggressive Prostate Cancer
Funder
National Health and Medical Research Council
Funding Amount
$1,592,353.00
Summary
Although most prostate cancers are not fatal, some develop into an aggressive form that is likely to progress and kill. How this happens and how to prevent these cancers, is not well understood. The study will examine the lives of men with aggressive prostate cancer, from the time of conception to adulthood, their family history and genetic characteristics to identify the role of life patterns and genes in the development of these cancers, seeking a basis for their prevention .
Identification Of Novel Low Penetrance Genes Associated With Melanoma Risk
Funder
National Health and Medical Research Council
Funding Amount
$399,830.00
Summary
Using pools of DNA samples we will conduct a genome-wide association study for melanoma predisposition genes. The most promising candidate genes will be followed up by sequencing and further geneotyping of additional SNPs in order to identify the causal variants.
A Case Control Study Of Hypertension In The Setting Of Poverty, Overcrowding And Infection.
Funder
National Health and Medical Research Council
Funding Amount
$603,331.00
Summary
It is unclear why chronic diseases are emerging in regions of significant disadvantage, i.e. where people are not overweight, are physically active and relatively young. We aim to identify factors responsible for the development of high blood pressure in a region where there is overcrowding, poverty, and infection. Low cost strategies to modify risk and educate the community can then be developed to prevent the emergence of these diseases.