Immediate And Long-term Safety Of Prescription Opioids In Pregnancy
Funder
National Health and Medical Research Council
Funding Amount
$447,603.00
Summary
Little is known about the consequences of prescription opioid use during pregnancy for fetal and childhood development. In this study covering over 5 million mother-child pairs, we will investigate the safety of opioid use in pregnancy, by combining rich data sources from Australia, and the 5 Nordic countries. We will translate findings into policy, guidelines and messaging for medicine consumers and prescribers to protect the safety of women and children.
Improving Outcomes And Cost Of Systemic Sclerosis Related Pulmonary Arterial Hypertension
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
My research program aims to improve the outcomes for those living with systemic sclerosis related pulmonary arterial hypertension (SSc-PAH) and reduce its associated societal burden through the evaluation and implementation of a novel PAH screening algorithm; the use of risk stratification tools in therapeutic decisions; and the development of a more streamlined management approach. My research will initiate collaboration across multiple medical disciplines and sites nationally.
There has been no significant breakthrough in the treatment of Systemic Lupus Erythematosus (SLE) for over 50 years. Treatment continues to rely on non-specific immunosuppressant drugs and glucocorticoids (GC, or ‘steroids’), and the impact on patients includes high mortality and poor quality of life. In this proposal, I will validate novel endpoints which will break the impasse in SLE drug development and develop tools for minimising GC use in SLE.
The Role Of Preconception And Perinatal Substance Use And Misuse In Childhood Social, Emotional And Behavioural Problems
Funder
National Health and Medical Research Council
Funding Amount
$1,562,250.00
Summary
This project will use perinatal and preconception data from three long-running Australian studies that have tracked the health and wellbeing of several thousand participants prior to parenthood. The aim is to understand how parental histories of substance use, and patterns of use during pregnancy, and in early life, shape offspring social, emotional and behavioural outcomes across childhood. Results will inform new approaches to preventing substance-related harms within and across generations.
Better Evidence And New Tools To Improve Health After Surgical Menopause
Funder
National Health and Medical Research Council
Funding Amount
$1,855,260.00
Summary
Surgical menopause is removal of both ovaries before natural menopause. Surgical menopause may have severe adverse health consequences including short-term symptoms and long-term risk of chronic disease, but more information is needed to inform evidence-based care. This study will deliver the best available evidence internationally on the short (up to 5 year) and long (>20 year) consequences of surgical menopause and new tools for clinicians and patients to integrate this evidence into practi ....Surgical menopause is removal of both ovaries before natural menopause. Surgical menopause may have severe adverse health consequences including short-term symptoms and long-term risk of chronic disease, but more information is needed to inform evidence-based care. This study will deliver the best available evidence internationally on the short (up to 5 year) and long (>20 year) consequences of surgical menopause and new tools for clinicians and patients to integrate this evidence into practiceRead moreRead less
Bridging The Gap: Using Data Science To Transform Care And Health Outcomes In Kidney Transplant Recipients
Funder
National Health and Medical Research Council
Funding Amount
$1,155,135.00
Summary
Despite substantive survival and quality of life benefits compared to being on dialysis, kidney transplant recipients suffer from premature death, largely due to complications such as cancer and cardiovascular. Using big data science, we will be able to predict these complications in the context of chronic immunosuppression, find new and better ways to identify at risk individuals, to deliver effective and efficient screening and treatment strategies in this vulnerable population.
From Understanding The Mechanisms To Implementing Conservative Management Of Musculoskeletal Conditions
Funder
National Health and Medical Research Council
Funding Amount
$2,339,215.00
Summary
Musculoskeletal pain is the leading cause of disability internationally and outcomes are worsening. This work will take a unique approach to study back pain from the mechanisms that occur at the cellular level to the interaction between a person’s physiology and psychology to understand why pain fluctuates, to understand how treatments can be more appropriately tailored for individuals, and to test how people with back pain can be supported to change behaviours and achieve recovery.
Next Generation Of Medical Devices And Diagnostics
Funder
National Health and Medical Research Council
Funding Amount
$2,738,220.00
Summary
This Investigator Project will deliver innovative technologies that improve patient wellbeing, make significant economic impact and contribute to answering complex biological questions. This will happen via delivering breakthrough technologies to prevent infections and diagnose diseases – two area that currently require substantial technological advances. In addition to helping patients and clinicians, the project will also deliver solid body of new knowledge that is currently missing.
Realising The World Health Organisation Targets For Elimination Of Cervical Cancer As A Public Health Problem: Effective Implementation And Scale-up Of HPV Vaccination And Cervical Screening In Australia, Regionally, And Globally
Funder
National Health and Medical Research Council
Funding Amount
$2,125,000.00
Summary
This fellowship focuses on improving cancer screening, particularly the implementation of HPV vaccination and cervical screening. CI Canfell will pursue an Australian, regional and global health agenda towards the elimination of cervical cancer. Her work is supporting the successful implementation of the new cervical screening program in Australia, provides crucial support to other countries in the region, and is directly informing the WHO global elimination strategy.
Optimising Treatment And Prevention Strategies To Accelerate Malaria Elimination
Funder
National Health and Medical Research Council
Funding Amount
$2,163,220.00
Summary
Elimination of malaria requires the assessment of interventions that not only treat individual infections successfully but also prevent disease at a population level. My proposal brings together data science approaches and mathematical modelling to develop new methods to assess antimalarial treatments and radical population interventions, and identify markers of drug resistance, accelerating malaria elimination efforts and building capacity in this emerging cross-disciplinary field.